| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Newly Diagnosed Patients with Inflammatory Bowel Disease: The Relationship Betw…
PMID: 33681688
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Although the prevalence and incidence of inflammatory bowel disease (IBD), a defective immune response of the gastrointestinal tract, has been incre…
Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune…
PMID: 33593426
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Lactobacillus reuteri strains are widely used as probiotics to prevent and treat inflammatory bowel disease by modulating the host's immu…
Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targ…
PMID: 33584726
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: The aim of this study was to evaluate nutritional status and sarcopenia in patients with inflammatory bowel disease (IBD) in clinical remission…
Human Nonalcoholic Steatohepatitis on a Chip.
PMID: 33553970
Year: Unknown
Relationship Type:
Therapeutic Applications
Score: 5.3
Nonalcoholic steatohepatitis (NASH), an advanced stage of nonalcoholic fatty liver disease (NAFLD), is a rapidly growing and global health problem co…
Activated intestinal muscle cells promote preadipocyte migration: a novel mecha…
PMID: 33468536
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: Creeping fat, the wrapping of mesenteric fat around the bowel wall, is a typical feature of Crohn's disease, and is associated with strict…
The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
PMID: 33436549
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Racial/ethnic disparities in outcomes exist for patients with inflammatory bowel disease (IBD) undergoing surgery. The underlying mechan…
Presence of Infection by Mycobacterium avium subsp. paratuberculosis in the Blo…
PMID: 33371478
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
A pharmaceutical grade synthetic tetradecapeptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (GEPON) that mimics the ezrin protein hin…
Butyrate Mitigates Weanling Piglets From Lipopolysaccharide-Induced Colitis by …
PMID: 33363521
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disorder is accompanied by the destruction of immunity homeostasis, gut microbiota perturbation, and chronic inflammatory liver di…
The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker …
PMID: 33295607
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Transendoscopic enteral tubing (TET) has been used in China as a novel delivery route for fecal microbiota transplantation (FMT) into th…
Bipolymeric Pectin Millibeads Doped with Functional Polymers as Matrices for th…
PMID: 33287276
Year: 2020
Relationship Type:
Correlation Studies
Score: 5.3
Targeted drug delivery systems are a very convenient method of treating inflammatory bowel disease. The properties of pectin make this biopolymer a s…
New drugs in the pipeline for the treatment of inflammatory bowel diseases: wha…
PMID: 33254032
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: Quantitative and kinetic insights into the drug exposure-disease response relationship might enhance our knowledge on loss of response and supp…
Therapeutic Potential of Triptolide as an Anti-Inflammatory Agent in Dextran Su…
PMID: 33240279
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Comment in J Pediatr Psychol. 2021 Jan 20;46(1):12-14. OBJECTIVE: Transition to adult IBD care continues to be a challenge. Efficacious models …
Periplaneta americana extract promotes intestinal mucosa repair of ulcerative c…
PMID: 33237174
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
PURPOSE: To investigate the mechanism of Periplaneta americana extract promoting intestinal mucosal repair of OXZ-induced colitis in rat. METHODS: Al…
Protective effect and mechanism of rebamipide on NSAIDs associated small bowel …
PMID: 33218942
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
PURPOSE: To investigate the protective effect and mechanism of rebamipide on NSAIDs associated intestinal injury. METHODS: Intestinal injury was indu…
Identification of gut microbiota and microbial metabolites regulated by an anti…
PMID: 33214705
Year: 2021
Relationship Type:
Target Validation
Score: 5.3
Lipocalin 2 (Lcn2), as an antimicrobial peptide is expressed in intestine, and the upregulation of intestinal Lcn2 has been linked to inflammatory bo…
A Cause-Effect Relationship of Infliximab and Pulmonary Embolism: A Case Report
PMID: 32923216
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Biological monoclonal antibodies such as infliximab have significantly remodeled inflammatory bowel disease's treatment course. Despite multiple side…
ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses
PMID: 32909611
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Polymorphisms in the autophagy-related protein 16 like 1 (ATG16L1) and nucleotide-binding oligomerization domain 2 (NOD2) genes are associated with C…
Do You See What I See? An Assessment of Endoscopic Lesions Recognition and Desc…
PMID: 32905160
Year: 2020
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: therapeutic monitoring of anti-TNF drugs and anti-drug antibody levels are useful for clinical decision-making, via the rationalization …
Altered paracellular permeability in intestinal cell monolayer challenged with …
PMID: 32898597
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Epithelial barrier alteration is a central event in the pathogenesis of inflammatory bowel diseases. Lipopolysaccharide, correlated to the pathogenes…
Allomyrina dichotoma larval extract attenuates intestinal barrier disruption by…
PMID: 32828534
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal epithelial cells form a barrier between the intestinal lumen and host connective tissues and play an important role in maintaining intesti…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||