| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
OGG1 augments the transcriptional activation of Foxp3 to promote iTreg differen…
PMID: 40694333
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
8-oxo-7,8-dihydroguanine (8-oxoG), the most frequent form of oxidative-DNA-base lesion caused by ROS, is recognized and repaired by 8-oxoguanine DNA …
Causal Inference and Shared Molecular Pathways in Crohn's Disease, Celiac Disea…
PMID: 40650227
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
This study explored the causal and molecular overlap among Crohn's disease (CD), celiac disease (CeD), and ankylosing spondylitis (AS). Bidirectional…
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phosph…
PMID: 40605975
Year: 2025
Relationship Type:
Target Validation
Score: 6.3
Ulcerative colitis is an idiopathic, chronic inflammatory bowel disease. Its pathogenesis is multifactorial involving inflammation and immune dysregu…
Integrated transcriptomic and proteomic profiling of colonic tissue in interleu…
PMID: 40593797
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Interleukin (IL)-10, a prominent anti-inflammatory cytokine predominantly secreted by various immune cells, plays a crucial role in the pathophysiolo…
Anti-Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Prot…
PMID: 40583166
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a complex inflammatory bowel disease characterized by multiple factors. Alleviating inflammation is the primary therapeuti…
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to f…
PMID: 40571769
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Increased reactive oxygen species (ROS) levels are a hallmark of inflammatory bowel disease (IBD) and constitute a major mechanism of epithelial cell…
Study on rTMS's therapeutic effect on constipation in Parkinson's disease via t…
PMID: 40515608
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
OBJECTIVE: This study investigates the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on constipation in Parkinson's dise…
Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction afte…
PMID: 40502773
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Unresolved tissue damage is a common feature of Inflammatory Bowel Disease (IBD) that facilitates disease progression. Here, we showed that high anim…
Illuminating prospects of probiotic Akkermansia muciniphila in intestinal infla…
PMID: 40466419
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Akkermansia muciniphila (A. muciniphila) is portrayed as an advantageous enteric bacterium with a particular property of mucin utilization. Emerging …
Protective effects of Nippostrongylus brasiliensis-derived uridine via the apic…
PMID: 40391223
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
INTRODUCTION: Inflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Co…
Bioinformatics analysis reveals shared molecular pathways for relationship betw…
PMID: 40375266
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, including ulcerative colitis (UC) and Crohn's disease, aff…
[Mechanism of total flavone of Abelmoschus manihot in treating ulcerative colit…
PMID: 40350912
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
This study delves into the mechanism of total flavone of Abelmoschus manihot(TFA) in treating ulcerative colitis(UC) and depression via inhibiting M1…
Shared genetic association between inflammatory bowel disease and acute myeloid…
PMID: 40304766
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Observational studies suggest that a history of inflammatory bowel disease (IBD) is associated with the onset of acute myeloid leukemia (…
Geniposide via enema alleviates colitis by modulating intestinal flora and bile…
PMID: 40279965
Year: 2025
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Geniposide (GE) has potential efficacy in treating ulcerative colitis (UC). However, its reactivity can be affected by rapid degradation …
Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosi…
PMID: 40220415
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Ferroptosis in colonic epithelial cells has been implicated in the development of ulcerative colitis (UC) and the accompanying gut leakag…
Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integ…
PMID: 40158828
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC), a chronic idiopathic inflammatory bowel disease, is characterized by a prolonged and recurre…
TXM-CB13 Improves the Intestinal Mucosal Barrier and Alleviates Colitis by Inhi…
PMID: 40085192
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
The activation of inflammasomes (NLRP3 and NLRP1) is central to the pathogenesis of inflammatory bowel disease (IBD). Here we examined the protective…
GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cel…
PMID: 40074327
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesi…
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in I…
PMID: 40032274
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Harnessing the effect of the cyclic GMP-AMP Synthase-STimulator of INterferon Genes (cGAS-STING) signaling pathway has emerged as a promising approac…
The Simultaneous Deletion of pH-Sensing Receptors GPR4 and OGR1 (GPR68) Amelior…
PMID: 40004018
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
G protein-coupled receptors (GPRs), including pro-inflammatory GPR4 and ovarian cancer GPR1 (OGR1/GPR68), are involved in the pH sensing of the extra…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||