| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Amelioration of murine experimental colitis using biocompatible cyclosporine A …
PMID: 32794147
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Lipoproteins are biodegradable and biocompatible natural carriers that can be utilized for the transport of hydrophobic drugs, such as cyclosporin A …
Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-ind…
PMID: 32779617
Year: 2020
Relationship Type:
Correlation Studies
Score: 5.3
Interleukin (IL)-19 is a cytokine clustered in the IL-20 cytokine superfamily with both anti-inflammatory and pro-inflammatory aspects depending on t…
Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Ove…
PMID: 32765484
Year: 2020
Relationship Type:
Target Validation
Score: 5.3
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs …
A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of D…
PMID: 32745270
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a heterogeneous cholangiopathy characterized by progressive biliary fibrosis. RNA sequen…
The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Infla…
PMID: 32722560
Year: 2020
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND & AIMS: Histopathology is an emerging treatment target in ulcerative colitis (UC) clinical trials. Our aim was to provide guidance on sta…
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity
PMID: 32693755
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal hyperpermeability is a complex metabolic process mediated by different pathways in close relation to the gut microbiota. Previous studies …
Oxymatrine loaded nitric oxide-releasing liposomes for the treatment of ulcerat…
PMID: 32650111
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Oxymatrine (OM) is the biologically active ingredient of Chinese medicinal herb Sophora flavescens, which is reported to be effective on alleviating …
Bioactive lipids, inflammation and chronic diseases
PMID: 32628989
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Endogenous bioactive lipids are part of a complex network that modulates a plethora of cellular and molecular processes involved in health and diseas…
ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through …
PMID: 32599618
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Evidence supports therapeutic drug monitoring (TDM) in improving efficacy and cost-effectiveness of anti-TNF therapy in inflammatory bow…
Berberine-Loaded Nanostructured Lipid Carriers Enhance the Treatment of Ulcerat…
PMID: 32581538
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
PURPOSE: Berberine (BBR), a major ingredient extracted from Coptis chinensis, is a natural drug with limited oral bioavailability. We developed nanos…
Heat shock transcription factor 2 inhibits intestinal epithelial cell apoptosis…
PMID: 32446363
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
UC is a chronic inflammatory disease of the colonic mucosa and lacks effective treatments because of unclear pathogenesis. Excessive apoptosis of IEC…
Effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyt…
PMID: 32445466
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
In this study, we aimed to explore the effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with coliti…
Post-Translational Modifications of Transcription Factors Harnessing the Etiolo…
PMID: 32369982
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Defects in mucosal immune balance can lead to colonic diseases such as inflammatory bowel diseases and colorectal cancer. With the advancement of und…
A Systematic Review on Cost-effectiveness Analyses of Therapeutic Drug Monitori…
PMID: 32311018
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in worsen quality of life and increased burden on public medica…
Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in C…
PMID: 32148442
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Polysaccharide from flammuliana velutipes improves colitis via regulation of co…
PMID: 32035958
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
The aim of this study is to investigate whether Flammuliana Velutipes Polysaccharide (FVP) could aid in the prevention of colitis. Effect of FVP on c…
Cigarette and Cannabis Smoking Effects on GPR15+ Helper T Cell Levels in Periph…
PMID: 32019074
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Background: Smoking causes widespread epigenetic changes that have been linked with an increased risk of smoking-associated diseases and elevated mor…
Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration…
PMID: 31937331
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakn…
Lycium barbarum lipid-based edible nanoparticles protect against experimental c…
PMID: 31924469
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Edible plant-derived nanoparticles (NPs) have attracted increasing attention in the treatment of ulcerative colitis (UC). Lycium barbarum (LB), a pop…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||