| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Mucosal gene transcription of ulcerative colitis in endoscopic remission
PMID: 31918598
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Aim/Objective: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. In UC, a wide range of criteria are used for disease remission, with …
Chitosan-modified lipid nanodrug delivery system for the targeted and responsiv…
PMID: 31887935
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Targeted and sensitive drug release at the colitis site is critical for the effective therapy of ulcerative colitis and reduction of side effects fro…
TRANSPLANTATION OF ADIPOSE-DERIVED MESENCHYMAL STEM CELLS IN REFRACTORY CROHN'S…
PMID: 31859918
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Crohn's disease is a pathological condition that has different options of treatment, but there are patients who need other therapeutic ap…
A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Dise…
PMID: 31861827
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through sha…
Efficacy and safety of bifid triple viable plus aminosalicylic acid for the tre…
PMID: 31764796
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
OBJECTIVE: Ulcerative colitis (UC), one of the most stubborn diseases, is mainly treated by aminosalicylic acid (ASA). However, the side effects of A…
Small-bowel carcinomas associated with celiac disease: transcriptomic profiling…
PMID: 31696360
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Celiac disease (CD) is a risk factor for developing small-bowel carcinoma with a 14-fold higher risk compared with general population. As small-bowel…
Implementing a Novel Quality Improvement-Based Approach to Data Quality Monitor…
PMID: 31646151
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Autophagy is a central component of integrated stress responses that influences many inflammatory diseases, including inflammatory bowel disease (IB…
Multiple outcome meta-analysis of gene-expression data in inflammatory bowel di…
PMID: 31634529
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
The saponins are natural surface-active glycosides which are the principal components of many popular herbal medicinal plants such as ginseng, astra…
Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-In…
PMID: 31632373
Year: 2019
Relationship Type:
Target Validation
Score: 5.3
The increasing incidence of pediatric inflammatory bowel disease, coupled with the efficiency of whole-exome sequencing, has led to the identificati…
Anti-Inflammatory Activity of a Peptide from Skipjack (Katsuwonus pelamis)
PMID: 31614893
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
In this paper, the effect of skipjack (Katsuwonus pelamis) enzymatic peptide (SEP), which was prepared and purified from a byproduct of skipjack, on …
Immune checkpoint molecules. Possible future therapeutic implications in autoim…
PMID: 31564474
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
During host immune response, an initial and sufficient activation is required to avoid infection and cancer, yet an excessive activation bears the ri…
Human induced pluripotent stem cell-derived mesenchymal stem cells promote heal…
PMID: 31558705
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: There has been limited evaluation of the association between vedolizumab trough concentration and clinical outcomes in patients with in…
ER stress activation in the intestinal mucosa but not in mesenteric adipose tis…
PMID: 31557250
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Gluten is only partially digested by intestinal enzymes and can generate peptides that can alter intestinal permeability, facilitating bacterial tr…
[Staphylococcus-induced immunglobulin E-dependent allergic anaphylaxis in Crohn…
PMID: 31537093
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Immunglobulin E (IgE)-based, irregularly recurring, severe anaphylactic reactions occurred in a 50-year-old European white male patient suffering als…
Isolation-by-environment as a driver of genetic differentiation among populatio…
PMID: 31427616
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND OBJECTIVES: The exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an …
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Spec…
PMID: 31265286
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: We designed a telemonitoring strategy for teenagers with inflammatory bowel disease to prevent an anticipated disease flare and avert u…
Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Ad…
PMID: 31258526
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), l…
Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine…
PMID: 31248978
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Opioids are highly effective analgesics, however, their therapeutic use is limited by adverse effects that include respiratory depression, dependence…
Antibiotic combinations that exploit heteroresistance to multiple drugs effecti…
PMID: 31209306
Year: 2019
Relationship Type:
Target Validation
Score: 5.3
OBJECTIVES: Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential g…
Induction of the metal transporter ZIP8 by interferon gamma in intestinal epith…
PMID: 31151823
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Transition metals are required for intestinal homeostasis and provide essential nutrients for the resident microbiota. Abnormalities in metal homeost…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||