| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inf…
PMID: 31052468
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to…
Relationship between Serum Adalimumab Levels and Clinical Outcome in the Treatm…
PMID: 31039560
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Adalimumab (ADA) is an anti-tumor necrosis factor agent that has been shown to be effective in inducing and maintaining remission in adul…
Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colit…
PMID: 31001315
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is a complex entity that includes Crohn disease and ulcerative colitis. It is characterized by a chronic proinflamm…
Cytomegalovirus infection in a T-cell lymphoma patient presenting with multiple…
PMID: 30993166
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Background and study aims Gastrointestinal ulcers are responsible for a wide spectrum of diseases. Infection, drug-induced enteritis, malignancy, va…
Colonic Mucosal Transcriptomic Changes in Patients with Long-Duration Ulcerativ…
PMID: 30954025
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Patients with ulcerative colitis [UC] with long disease duration have a higher risk of developing colitis-associated cancer [CAC…
JAK Inhibition: The Most Promising Agents in the IBD Pipeline?
PMID: 30950344
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Primary immunodeficiencies (PIDs) are inherited disorders of the immune system, associated with a considerable increase in susceptibility to infecti…
Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modul…
PMID: 30851581
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The Tripterygium glycosides (TG) is the main active extractive of Tripterygium wilfordii Hook F and is widely used in clinical practice t…
Infliximab Exposure-Response Relationship and Thresholds Associated With Endosc…
PMID: 30613004
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND & AIMS: Therapeutic drug monitoring might be used to personalize infliximab treatment of patients with ulcerative colitis (UC), although e…
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personal…
PMID: 30604764
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define…
Peripheral neuropathy and gastroenterologic disorders: an overview on an underr…
PMID: 30561392
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIM OF THE WORK: Although peripheral neuropathies in children are often of genetic origin, acquired causes should be carefully looked …
Differences in Peripheral and Tissue Immune Cell Populations Following Haematop…
PMID: 30521002
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Recent studies have shown the efficacy of autologous haematopoietic stem cell transplantation [HSCT] in severely refractory Croh…
Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation pro…
PMID: 30503401
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Fatigue is a burdensome, multidimensional, and multifactorial symptom that is associated with a wide array of chronic illnesses, specifically occurr…
An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intes…
PMID: 30405600
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent response…
Implications of population connectivity studies for the design of marine protec…
PMID: 30378207
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The genetic and immunological factors that contribute to differences in susceptibility and progression between sub-types of inflammatory…
Coordination of ENT2-dependent adenosine transport and signaling dampens mucosa…
PMID: 30333323
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Downregulation of P-glycoprotein (P-gp) is implicated in the pathophysiology of inflammatory bowel disease (IBD). Berberine, a principal isoquinolin…
Patterns and predictors of long-term retention of inflammatory bowel or rheumat…
PMID: 30271124
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) represents a group of progressive disorders characterized by recurrent chronic inflammation of the gut. Ulcerative …
Understanding and predicting disease relationships through similarity fusion
PMID: 30169824
Year: 2019
Relationship Type:
Target Validation
Score: 5.3
MOTIVATION: Combining disease relationships across multiple biological levels could aid our understanding of common processes taking place in disease…
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophag…
PMID: 30124884
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hem…
Chronic intestinal inflammation in mice expressing viral Flip in epithelial cel…
PMID: 30104627
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Viruses are present in the intestinal microflora and are currently discussed as a potential causative mechanism for the development of inflammatory b…
Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis…
PMID: 30085215
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine histologically characterized by indistinct sustained …
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||