| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recogn…
PMID: 30068593
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of…
Epigallocatechin-3-Gallate Regulates Anti-Inflammatory Action Through 67-kDa La…
PMID: 29723847
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Alterations in the gut microbiota composition play a key role in the development of chronic diseases such as inflammatory bowel disease (IBD). The p…
Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's dis…
PMID: 29688802
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: Infliximab is important in the therapeutic arsenal of Crohn's disease (CD). However, its effect on mucosal barrier function is not fully u…
Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK e…
PMID: 29518435
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
In this study, we aimed to evaluate the anti-inflammatory and protective effects of Ziziphus spina-christi fruit extract (ZFE) against acetic acid (A…
Mesenteric injection of adipose-derived mesenchymal stem cells relieves experim…
PMID: 29422993
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
Efficient delivery routes are critical for the effectiveness of adipose-derived mesenchymal stem cells (ADMSCs) in treating inflammatory bowel diseas…
Rare Risk Variants Identification by Identity-by-Descent Mapping and Whole-Exom…
PMID: 29411265
Year: 2018
Relationship Type:
Target Validation
Score: 5.3
PURPOSE: Depressive symptomatology in IBD patients is known to predict disease activity, which, in turn, can increase depressive symptoms in perpetu…
Process, optimization, and characterization of budesonide-loaded nanostructured…
PMID: 29376433
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
The major challenge involved in the treatment of inflammatory bowel disease is targeted delivery of the drug at the site of inflammation. As nanopart…
Adipokine apelin ameliorates chronic colitis in Il-10(-/-) mice by promoting in…
PMID: 29309764
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Both mesenteric adipose tissue (MAT) and lymphatic vessels (LVs) play important roles in the pathogenesis of Crohn's disease (CD), and adipokines hav…
NF-κB and the Transcriptional Control of Inflammation
PMID: 29305014
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
The NF-kappaB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. …
GPR120: Mechanism of action, role and potential for medical applications
PMID: 29176006
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
G protein-coupled receptors (GPCRs) constitute a family of transmembrane proteins that mediate many cellular processes. GPR120/FFAR4, a receptor from…
Exposure-response relationship of certolizumab pegol induction and maintenance …
PMID: 29159893
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Therapeutic drug monitoring may optimize therapy for Crohn's disease (CD). AIM: To use a population pharmacokinetic model that accounts f…
TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory…
PMID: 29114179
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovasc…
Fluorescence-labeled liposome accumulation in injured colon of a mouse model of…
PMID: 29037813
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Drug delivery systems maximize the efficacy of drugs by improving their pharmacokinetic profiles, pharmacodynamic effects, or both and reducing their…
Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epitheli…
PMID: 29038361
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory diseases of the gut are associated with altered electrolyte and water transport, leading to the development of diarrhea. Epithelially ex…
Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological a…
PMID: 28983454
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
PURPOSE OF REVIEW: The modeling of biological processes in vitro provides an important tool to better understand mechanisms of development and diseas…
Identifying Cryptic Relationships
PMID: 28980241
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Lactadherin was originally described due to its appearance in milk, but is abundantly expressed especially by professional and nonprofessional phago…
Modulation of VIPergic phenotype of enteric neurons by colonic biopsy supernata…
PMID: 28857361
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.3
Renal transplant recipients who present with gastrointestinal complaints may have symptoms related to their underlying renal disease or secondary to…
MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediator…
PMID: 28827082
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
The term inflammatory bowel disease (IBD) refers principally to two major categories of chronic relapsing inflammatory intestinal disorders: Crohn's…
Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipo…
PMID: 28789943
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Visceral fat accumulation as observed in Crohn's disease and obesity is linked to chronic gut inflammation, suggesting that accumulation of gut adipo…
ToF-SIMS and principal component analysis of lipids and amino acids from inflam…
PMID: 28776072
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
In spite of the well-established histopathological phenotyping of IBD-associated preneoplastic and neoplastic lesions, their molecular landscape rem…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||