| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesi…
PMID: 28751472
Year: 2017
Relationship Type:
Clinical Research
Score: 5.3
Parkinson's disease (PD) is a neurodegenerative disease, whereas Crohn's disease is an inflammatory bowel disease. Interestingly, polymorphisms in th…
Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammat…
PMID: 28694660
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS: De…
Pharmacokinetics of piperacillin-tazobactam in plasma, peritoneal fluid and per…
PMID: 28694230
Year: 2017
Relationship Type:
Clinical Research
Score: 5.3
Piperacillin-tazobactam (PIP-TAZ) is commonly used to treat intraabdominal infections; however, its penetration into abdominal sites is unclear. A ph…
Signaling pathways induced by serine proteases to increase intestinal epithelia…
PMID: 28671992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative…
Late-Onset Inflammatory Bowel Disease-Like Syndrome after Ipilimumab Therapy: A…
PMID: 28626406
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Antitumor immunotherapy has become a major player in cancer therapy. Ipilimumab is a humanized monoclonal antibody against the cytotoxic …
Phospholipid-drug conjugates as a novel oral drug targeting approach for the tr…
PMID: 28627471
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
Comment in Nat Rev Rheumatol. 2017 Apr;13(4):198. Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with…
Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue a…
PMID: 28487813
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
The linear ubiquitin chain assembly complex (LUBAC), composed of heme-oxidized IRP2 ubiquitin ligase 1 (HOIL1), HOIL1-interacting protein (HOIP), an…
Altered activation of peripheral CD8+ T cells in pediatric Crohn's disease
PMID: 28300604
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: Although Crohn's disease (CD) is an extensively investigated autoimmune condition, knowledge on early phase activation of lymphocytes, especiall…
Screening of the optimized prescription from Suqingwan in terms of its therapeu…
PMID: 28284792
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Suqingwan (SQW), a traditional Chinese medicine used for treating ulcerative colitis (UC), is composed of 13 kinds of…
Adiponectin confers protection from acute colitis and restricts a B cell immune…
PMID: 28258220
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Adiponectin demonstrates beneficial effects in various metabolic diseases, including diabetes, and in bowel cancer. Recent data also suggest a protec…
RIP3 deficiency exacerbates inflammation in dextran sodium sulfate-induced ulce…
PMID: 28256024
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a chronic intestinal inflammatory disease. The receptor-interacting protein kinase 3 (RIP3) was reported to be involved in…
High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patient…
PMID: 28110099
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Bile acids are amphipathic molecules that were previously known to serve as fat solubilizers in the intestine in postprandial conditions. In the las…
Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Protei…
PMID: 28098808
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Drug allergies are developed by antibody or cell-mediated reactions as immunologic mechanisms. It has been demonstrated that hypersensitivity reacti…
Altered pattern of tumor necrosis factor-alpha production in peripheral blood m…
PMID: 27895399
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
AIM: To evaluate the inflammatory state in Crohn's disease (CD) patients and correlate it with genetic background and microbial spreading. METHODS: B…
A20 inhibits lipopolysaccharide-induced inflammation in enterocytes
PMID: 27867687
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
AIM: To examine the role of A20 in the regulation of intestinal epithelial cells (IECs) inflammation. METHODS: Using gene transfection, both stable o…
Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and…
PMID: 27866974
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Bioactive sphingolipids are regulators of immune cell function and play critical roles in inflammatory conditions including ulcerative colitis. As on…
Genetics meets pathology - an increasingly important relationship
PMID: 27859271
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
The analytical power of modern methods for DNA analysis has outstripped our capability to interpret and understand the data generated. To make good u…
Enhancement of Muramyl Dipeptide-Dependent NOD2 Activity by a Self-Derived Pept…
PMID: 27791288
Year: 2017
Relationship Type:
Correlation Studies
Score: 5.3
Nucleotide-binding and oligomerization domain like receptors (NLR) are pattern recognition receptors used to provide rapid immune response by detecti…
Postoperative excessive gain in visceral adipose tissue as well as body mass in…
PMID: 27666926
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Erratum in Cancer Sci. 2015 Oct;106(10):1481. Patients with inflammatory bowel disease (IBD) have an increased risk of developing colitis-assoc…
Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Different…
PMID: 27648924
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
Nucleic acid therapy can be beneficial for the local treatment of gastrointestinal diseases that currently lack appropriate treatments. Indeed, sever…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||