| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Therapeutic manipulation of the microbiota: past, present, and considerations f…
PMID: 27619640
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The growing appreciation of the potential role of indigenous microbiota in disease has resulted in a concomitant interest in manipulating…
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic ce…
PMID: 27518435
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and prevention of disease. A caspase-independent regulated fo…
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic b…
PMID: 27458604
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIMS: The human intestinal peptide transporter 1, hPepT1, is expressed in the small intestine at low levels in the healthy colon and u…
Pharmacokinetics and Exposure-response Relationship of Golimumab in Patients wi…
PMID: 27440869
Year: 2017
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND AND AIMS: To assess golimumab pharmacokinetics [PK] and exposure-response [ER] in adults with moderate-to-severe ulcerative colitis [UC] f…
Protective effect of Periplaneta americana extract in ulcerative colitis rats i…
PMID: 27309769
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
CONTEXT: Periplaneta americana L. (Dictyoptera; Blattaria) has been traditional used to treat ulcers, burns and heart disease in southwestern China. …
A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients …
PMID: 27307154
Year: 2016
Relationship Type:
Clinical Research
Score: 5.3
Infectious bursal disease (IBD), caused by IBD virus (IBDV), is an acute, highly contagious immunosuppressive avian disease. Although age-dependent …
How to Manipulate the Microbiota: Fecal Microbiota Transplantation
PMID: 27161356
Year: 2016
Relationship Type:
Correlation Studies
Score: 5.3
BACKGROUND & AIMS: The pathogenesis of inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response. Expression of the…
Synthesis and Structure-Activity Relationships of N-Dihydrocoptisine-8-ylidene …
PMID: 26981782
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
In this study, natural quaternary coptisine was used as a lead compound to design and synthesize structurally stable and actively potent coptisine an…
Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regula…
PMID: 26968114
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
Green tea-derived polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been extensively studied for its antioxidant and anti-inflammatory properties …
Phosphatase Wip1 Masters IL-17-producing Neutrophil-mediated Colitis in Mice
PMID: 26950306
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
Wild-type p53-induced phosphatase 1 (Wip1) is currently believed to be a promising drug target for cancer therapy. Our recent studies showed that del…
Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Col…
PMID: 26891260
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholester…
[Gut microbiota: Description, role and pathophysiologic implications]
PMID: 26749318
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
The human gut contains 10(14) bacteria and many other micro-organisms such as Archaea, viruses and fungi. Studying the gut microbiota showed how this…
JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hu…
PMID: 26608188
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is the result of a combination of environmental, genetic and immunologic factors that trigger an uncontrolled immu…
Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Mo…
PMID: 26488575
Year: 2015
Relationship Type:
Therapeutic Applications
Score: 5.3
Barrier dysfunction in inflammatory bowel diseases implies enhanced paracellular flux and lowered transepithelial electrical resistance (TER) causing…
Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Pa…
PMID: 26481854
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND & AIMS: Crohn's disease (CD) is associated with a dysregulated immune response to commensal micro-organisms in the intestine. Mice deficie…
The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targetin…
PMID: 26376209
Year: 2015
Relationship Type:
Therapeutic Applications
Score: 5.3
Interleukin-17 (IL-17) has been proved to be involved in the pathogenesis of several autoimmune diseases, including lupus, rheumatoid arthritis, mult…
Mesenteric Adipocyte Dysfunction in Crohn's Disease is Associated with Hypoxia
PMID: 26332309
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Abnormalities in mesenteric adipose tissue (MAT) have long been recognized; however, the functional changes in the mesenteric adipocytes …
Synthesis and Structure-Activity Relationships of Quaternary Coptisine Derivati…
PMID: 26321079
Year: 2015
Relationship Type:
Correlation Studies
Score: 5.3
Thirty quaternary coptisine derivatives from a synthesized library were found to activate the in vitro transcription of x-box-binding protein 1 (XBP1…
[Ipilimumab-induced colitis: A new challenge for gastroenterologists]
PMID: 26298799
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
Many drugs can produce enterocolitis and they should always be included in the differential diagnosis of this clinical picture. Entities such as anti…
ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inf…
PMID: 26256794
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
ErbB3 binding protein-1 (EBP1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, differentiation and apoptosis. Previous dat…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||