| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Peripheral neuropathy: an underreported neurologic manifestation of inflammator…
PMID: 26211733
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: One of the most frequent neurologic complications reported in inflammatory bowel disease population is peripheral neuropathy; ho…
Δ(9)-Tetrahydrocannabinol (THC) enhances lipopolysaccharide-stimulated tissue f…
PMID: 26085816
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Immunomodulatory effects in humans of Delta(9-)Tetrahydrocannabinol (THC), the psychoactive component of marijuana are controversial. Tis…
Embelin lipid nanospheres for enhanced treatment of ulcerative colitis - Prepar…
PMID: 25957524
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
Aim of the present study is to develop embelin lipid nanospheres (LNE) for better treatment of ulcerative colitis. Embelin LNs were developed using s…
Lipidomic Profiling in Inflammatory Bowel Disease: Comparison Between Ulcerativ…
PMID: 25895111
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Crohn's disease and ulcerative colitis are the two spectral variations of inflammatory bowel diseases (IBD). The complex interplay betwe…
A study evaluating the bidirectional relationship between inflammatory bowel di…
PMID: 25719528
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Metabolite monitoring and response predictors to azathioprine (AZA) in pediatric inflammatory bowel disease (IBD) are debatable. In an a…
[Experimental study of adipose-derived mesenchymal stem cells in the treatment …
PMID: 25656034
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: To explore the efficacy of adipose-derived mesenchymal stem cells (ADMSCs) in a murine model of inflammatory bowel disease, and its potent…
Amelioration of mitochondrial dysfunction-induced insulin resistance in differe…
PMID: 25474091
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Regular consumption of moderate doses of wine is an integral part of the Mediterranean diet, which has long been considered to provide remarkable he…
Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW4…
PMID: 25471891
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
The anti-inflammatory effect of piperine has been largely investigated in macrophages, but its activity on epithelial cells in inflammatory settings …
Lipopolysaccharide: basic biochemistry, intracellular signaling, and physiologi…
PMID: 25349574
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Lipopolysaccharide (LPS), a main constituent of Gram-negative bacterial membrane, specifically activates Toll-like receptor 4, leading to the product…
The relationship between infliximab concentrations, antibodies to infliximab an…
PMID: 25336114
Year: 2015
Relationship Type:
Target Validation
Score: 5.3
OBJECTIVE: Although low infliximab trough concentrations and antibodies to infliximab (ATI) are associated with poor outcomes in patients with Crohn'…
Cannabinoids alleviate experimentally induced intestinal inflammation by acting…
PMID: 25275313
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIMS: In an attempt to further investigate the role of cannabinoid (CB) system in the pathogenesis of inflammatory bowel diseases, we …
Bursal transcriptome of chickens protected by DNA vaccination versus those chal…
PMID: 25267176
Year: 2015
Relationship Type:
Therapeutic Applications
Score: 5.3
T helper 17 (Th17) cells have been implicated in the pathogenesis of most common autoimmune diseases, including psoriasis, rheumatoid arthritis (RA)…
Role of fat and adipokines in intestinal inflammation
PMID: 25188546
Year: 2014
Relationship Type:
Correlation Studies
Score: 5.3
PURPOSE OF REVIEW: This review summarizes current knowledge on the contribution of mesenteric adipose tissue in intestinal inflammation. We will desc…
Genetic population structure of the blister beetle, Gnathium minimum: core and …
PMID: 25160848
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), which can increase the risk of colorectal cancer (CRC), includes two primary subtypes, ulcerative colitis (UC) and…
Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mappin…
PMID: 24956270
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Profiles of sequence variants that influence gene transcription are very important for understanding mechanisms that affect phenotypic variation and …
TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication …
PMID: 24942577
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
We have previously demonstrated that exosomes from dendritic cells (DCs) secreting TGF-β1 (sTGF-β1-EXOs) delay the development of murine inflammator…
Dipeptidyl peptidase-4 inhibitors in type 2 diabetes may reduce the risk of aut…
PMID: 24919467
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: Dipeptidyl peptidase-4 (DPP4), also known as CD26, is a transmembrane glycoprotein that has a costimulatory function in the immune respons…
TH9 cells that express the transcription factor PU.1 drive T cell-mediated coli…
PMID: 24908389
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
The molecular checkpoints that drive inflammatory bowel diseases are incompletely understood. Here we found more T cells expressing the transcription…
Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's dise…
PMID: 24887376
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Crohn's disease (CD) is associated with complex pathogenic pathways involving defects in apoptosis mechanisms. Recently, mesenteric adipo…
Adipose tissue immune response: novel triggers and consequences for chronic inf…
PMID: 24823865
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 5.3
Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high preval…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||