| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
A prospective cohort study to determine the relationship between serum inflixim…
PMID: 24689499
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Patients with Crohn's disease (CD) may experience disease relapse on maintenance infliximab. Anti-drug antibodies likely contribute to lo…
Relationship estimation from whole-genome sequence data
PMID: 24497848
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is thought to result from a dysregulated immune response to intestinal microbial flora in individuals with genetic …
Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn'…
PMID: 24466433
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Dendritic cells and macrophages play an essential role in immune homeostasis in the intestine. They have the critical task of maintaining the balance…
Integrative analysis of the microbiome and metabolome of the human intestinal m…
PMID: 24450808
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition, the etiology of which is composed of factors such as the environmen…
Peripheral neutrophil functions and cell signalling in Crohn`s disease
PMID: 24367671
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
The role of the innate immunity in the pathogenesis of Crohn's disease (CD), an inflammatory bowel disease, is a subject of increasing interest. Neut…
Protein profiles of peripheral blood mononuclear cells as a candidate biomarker…
PMID: 24237878
Year: 2014
Relationship Type:
Clinical Research
Score: 5.3
OBJECTIVES: To investigate the pathophysiology of Behcet's disease (BD) and find biomarkers for the disease, we analysed protein profiles of peripher…
Analysis of immune-related loci identifies 48 new susceptibility variants for m…
PMID: 24076602
Year: 2013
Relationship Type:
Clinical Research
Score: 5.3
Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligome…
Detection of muramyl dipeptide-sensing pathway defects in monocytes of patients…
PMID: 23837874
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Peripheral blood mononuclear cells of Crohn's disease (CD) patients with the common 1007fs mutation of the caspase recruitment domain-containing 15/n…
The impact of physical activity and nutrition on inflammatory bowel disease: th…
PMID: 23756389
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Crohn's disease and ulcerative colitis are both chronic inflammatory bowel diseases (IBDs) characterized by a cyclical nature, which alternates betwe…
Relationships between pharmacokinetics and efficacy of Xie-xin decoction in rat…
PMID: 23619018
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Xie-xin decoction (XXD) has been used as a classic formula in China for the treatment of gastrointestinal dysfunction…
Rivastigmine alleviates experimentally induced colitis in mice and rats by acti…
PMID: 23469045
Year: 2013
Relationship Type:
Correlation Studies
Score: 5.3
The cholinergic anti-inflammatory system and alpha7 nicotinic receptors in macrophages have been proposed to play a role in neuroimmunomodulation and…
Novel transcriptional regulation of VEGF in inflammatory processes
PMID: 23414097
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Vascular endothelial growth factor (VEGF) is a critical angiogenic factor affecting endothelial cells, inflammatory cells and neuronal cells. In addi…
Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine…
PMID: 23306083
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.3
Uridine diphosphate (UDP) is a proinflammatory nucleotide implicated in inflammatory bowel disease. Intestinal alkaline phosphatase (IAP) is a gut mu…
[Multiple sclerosis as an adverse effect of anti-tumor necrosis factor agents: …
PMID: 23218770
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.3
Anti-tumor necrosis factor alpha (TNF-alpha) agents have been a great advantage in the treatment of inflammatory bowel disease. The safety profile of…
[Effects of qingchang huashi recipe on the dendritic cells of the colonic mucos…
PMID: 23163148
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: To observe the effects of qingchang huashi recipe (QHR) on the dendritic cells (DCs) of experimental colitis rats, thus exploring its poss…
The transcription factor T-bet regulates intestinal inflammation mediated by in…
PMID: 23063332
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-…
Engineered MSCs from Patient-Specific iPS Cells
PMID: 22915200
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.3
Mesenchymal stroma/stem cells (MSCs) represent a heterogenic cell population that can be isolated from various tissues of the body or can be generate…
Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages w…
PMID: 22637701
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.3
OBJECTIVE: To investigate the effect of adipose-derived mesenchymal stromal cells (ASCs) on the activation state of macrophages (MPhi) in vitro, and …
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidas…
PMID: 22539793
Year: 2012
Relationship Type:
Clinical Research
Score: 5.3
Dipeptidylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been implicated in autoimmune pathophysiology. B…
Bioinformatics analysis reveals transcriptome and microRNA signatures and drug …
PMID: 22488912
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Studies with healthy volunteers have demonstrated that antidepressants can improve immunoregulatory activity and thus they may have a p…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||