| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non…
PMID: 40000575
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Cognitive impairments are common clinical manifestation of Alzheimer's disease, vascular dementia, type 2 diabetes mellitus, and autoimmune diseases.…
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining in…
PMID: 39987261
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Dysfunctional NF-kappaB signaling is critically involved in inflammatory bowel disease (IBD). We investigated the mechanism by which RIPK1 and TRADD,…
Novel Transcriptomic Signatures in Fibrostenotic Crohn's Disease: Dysregulated …
PMID: 39977234
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcr…
DS0384 Alleviates Necrotizing Enterocolitis: Secretes N-carbamyl glutamic Acid …
PMID: 39947675
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disease linked to gut microbiome dysbiosis. This study evaluates the efficac…
mRNA expression profile from whole blood revealed a cluster of 25 shared differ…
PMID: 39893753
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Multiple Sclerosis (MS) and Inflammatory Bowel Disease (IBD) are immune-mediated disorders with a significant concurrence among patients …
The protective effect of amitriptyline on experimental colitis through inhibiti…
PMID: 39892990
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Amitriptyline, a pleiotropic tricyclic antidepressant, possesses antioxidant and anti-inflammatory properties. Despite its diverse benefits, the spec…
The current state of knowledge on the role of NKG2D ligands in multiple scleros…
PMID: 39866909
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease with demyelinating inflammatory characteristics. It is the most common nont…
Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/T…
PMID: 39840084
Year: 2025
Relationship Type:
Target Validation
Score: 6.3
INTRODUCTION: Despite evidence of the efficacy of decursinol angelate (DA), a prescription medication derived farom traditional Chinese medicine, in …
Oral Akkermansia muciniphila Biomimetic Nanotherapeutics for Ulcerative Colitis…
PMID: 39817352
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.3
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that dri…
Uncovering NK cell sabotage in gut diseases via single cell transcriptomics
PMID: 39752457
Year: 2025
Relationship Type:
Target Validation
Score: 6.3
The identification of immune environments and cellular interactions in the colon microenvironment is essential for understanding the mechanisms of ch…
Combined Bulk and Single-Cell Transcriptomic Analysis to Reveal the Potential I…
PMID: 39680254
Year: 2024
Relationship Type:
Target Validation
Score: 6.3
Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are both autoimmune disorders caused by dysregulated immune responses. Still, there is a…
N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through…
PMID: 39420190
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
The NOD2 signaling pathway, which plays an important role in the mechanisms of inflammatory bowel disease (IBD) development, has been closely associa…
Intestinal flora and inflammatory bowel disease: Causal relationships and predi…
PMID: 39381207
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is significantly influenced by intestinal flora. Unde…
Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfu…
PMID: 39229116
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND & AIMS: Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Patient-derived or…
Discerning Endoscopic Severity of Inflammatory Bowel Disease by Scoping the Per…
PMID: 39165421
Year: 2024
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND AND AIMS: Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBDs) with an incompletely understood …
A Family of Cyclic Lipopeptides Found in Human Isolates of Bacillus Ameliorates…
PMID: 39110366
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: The Bacillus-derived cyclic lipopeptides (surfactin, iturin, and fengycin) form potent Heterogeneous Lipopeptide Micelle (HeLM) complexes…
Investigating the molecular mechanisms underlying the co-occurrence of Parkinso…
PMID: 39043798
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
Parkinson's disease (PD) and inflammatory bowel disease (IBD) are chronic diseases affecting the central nervous system and gastrointestinal tract, r…
The Mechanism of "Treating Different Diseases with the Same Treatment" by Qiang…
PMID: 38808131
Year: 2024
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are prevalent autoimmune disorders that often co-occur, posing significa…
Exploration of the core pathway of inflammatory bowel disease complicated with …
PMID: 38698841
Year: 2024
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Inflammatory bowel disease (IBD) is often associated with complex extraintestinal manifestations. The incidence of nonalcoholic fatty liv…
Categorization of the effects of E. coli LF82 and mutants lacking the chuT and …
PMID: 38403884
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
The precise etiology of inflammatory bowel diseases (IBDs) remains elusive. The Escherichia coli strain LF82 (LF82) is known to be associated with IB…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||