| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Transcriptomic profiling reveals a pronociceptive role for angiotensin II in in…
PMID: 38293826
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently a…
Correlations between genetically predicted lipid-lowering drug targets and infl…
PMID: 38287401
Year: 2024
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Millions of individuals globally suffer from Inflammatory bowel diseases (IBDs). There is a dearth of large population-based investigatio…
Transcriptome analysis identifies genetic risk markers and explores the pathoge…
PMID: 38199515
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammatory bowel disease (IBD) is an incurable and disabling bowel disease driven by multiple risk factors that severely limit patients' quality of…
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and …
PMID: 38160982
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
Patients with inflammatory bowel disease, including ulcerative colitis (UC) and Crohn's disease, have a high incidence of psychiatric disorders, incl…
Role of the Hippo pathway in autoimmune diseases
PMID: 38042379
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.3
The immune system is an important defense against diseases, and it is essential to maintain the homeostasis of the body's internal environment. Under…
MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regenerat…
PMID: 37939210
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
Intestinal epithelium undergoes regeneration after injuries, and the disruption of this process can lead to inflammatory bowel disease and tumorigene…
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates…
PMID: 37793204
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Aryl hydrocarbon receptor (AhR) plays an important role in the occurrence and development of ulcerative colitis (UC). In this study, the …
Establishment of a 96-well transwell system using primary human gut organoids t…
PMID: 37773535
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
Disruptions in the gut epithelial barrier can lead to the development of chronic indications such as inflammatory bowel disease (IBD). Historically, …
Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 k…
PMID: 37673444
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease.…
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome acti…
PMID: 37586642
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 6.3
INTRODUCTION: The perturbations of gut microbiota could interact with excessively activated immune responses and play key roles in the etiopathogenes…
Construction of gene subgroups of Crohn disease based on transcriptome data
PMID: 37543814
Year: 2023
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: The global prevalence of Crohn disease (CD), a chronic inflammatory disease of the intestine, has been increasing; however, the etiology …
Amelioration of DSS-induced colitis in mice by TNF-α-stimulated mesenchymal ste…
PMID: 37532297
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Mesenchymal stem cells (MSCs) have been investigated as therapeutic agents for inflammatory bowel disease (IBD). Stimulation of MSCs with…
Association between the use of lipid-lowering drugs and the risk of inflammator…
PMID: 37515404
Year: 2023
Relationship Type:
Target Validation
Score: 6.3
BACKGROUND: Observational studies have suggested an association between lipid-lowering drugs and inflammatory bowel disease (IBD) risk. This study ai…
Lipids, lipid-lowering agents, and inflammatory bowel disease: a Mendelian rand…
PMID: 37350960
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: To assess the causal role of lipid traits and lipid-lowering agents in inflammatory bowel disease (IBD). METHODS: Univariable mendelian r…
Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative col…
PMID: 37161415
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Ulcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment str…
Protective effect and mechanism insight of purified Antarctic kill phospholipid…
PMID: 37016023
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
Antarctic krill oil is functional oil and has a complex phospholipids composition that poses difficulties in elucidating its effect mechanism on ulce…
Exploring the Pipeline of Novel Therapies for Inflammatory Bowel Disease; State…
PMID: 36979724
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 6.3
Crohn's disease (CD) and ulcerative colitis (UC), known as inflammatory bowel diseases (IBD), are characterized by chronic inflammation of the gastro…
Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer
PMID: 36973501
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammation is known to be an essential driver of various types of cancer. An increasing number of studies have suggested that the occur…
Exosomal miR-103a-3p from Crohn's Creeping Fat-Derived Adipose-Derived Stem Cel…
PMID: 36897738
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND AND AIMS: Mesenteric adipose tissue hypertrophy is a hallmark of Crohn's disease [CD], and creeping fat [CF] is unique to CD. Adipose-deri…
Qingre Xingyu recipe exerts inhibiting effects on ulcerative colitis developmen…
PMID: 36890151
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
As a chronic inflammatory bowel disease, ulcerative colitis (UC) imposes a significant burden on public healthcare worldwide due to its increasing mo…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||