| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The Multiple Roles of Periostin in Non-Neoplastic Disease
PMID: 36611844
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Periostin, identified as a matricellular protein and an ECM protein, plays a central role in non-neoplastic diseases. Periostin and its variants have…
Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and…
PMID: 36591260
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psor…
Single-cell and microarray chip analysis revealed the underlying pathogenesis o…
PMID: 36445533
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
The morbidity rate of ulcerative colitis (UC) in the world is increasing year by year, recurrent episodes of diarrhea, mucopurulent and bloody stools…
Protopine alleviates lipopolysaccharide-triggered intestinal epithelial cell in…
PMID: 36335450
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammatory bowel disease (IBD) is a common chronic intestinal disease. Protopine isolated from different plants has been investigated t…
Protective effect of Schistosoma japonicum eggs on TNBS-induced colitis is asso…
PMID: 36304936
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammatory bowel diseases (IBDs) have been classified as modern refractory diseases. However, safe, well-tolerated, and effective treatments for IB…
Isoflavone consumption reduces inflammation through modulation of phenylalanine…
PMID: 36289122
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
INTRODUCTION: Phytoestrogens found in soy, fruits, peanuts, and other legumes, have been identified as metabolites capable of providing beneficial ef…
The lack of transcriptionally active Nrf2 triggers colon dysfunction in female …
PMID: 36155082
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND AND AIM: The proper functioning of the gastrointestinal system relies on an intricate crosstalk between a plethora of cell types and signa…
Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg…
PMID: 36077306
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
The pharmacotherapy of inflammatory bowel disease (IBD) is still not fully effective and safe. Attempts to search for new IBD drugs remain an incessa…
Proteomic and lipidomic biomarkers in the diagnosis and progression of inflamma…
PMID: 36043901
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
PURPOSE: There is an increasing prevalence of inflammatory bowel disease (IBD) and to date, no effective treatment has been developed and the exact e…
Effects of Milk-Derived Extracellular Vesicles on the Colonic Transcriptome and…
PMID: 35893911
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Evidence shows that effective nutritional intervention can prevent or mitigate the risk and morbidity of inflammatory bowel disease (IBD). Bovine mil…
Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with…
PMID: 35767888
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Vitamin D has anti-inflammatory efficacy against ulcerative colitis (UC), however, the mechanism is yet little understood. OBJECTIVE: To …
When fat meets the gut-focus on intestinal lipid handling in metabolic health a…
PMID: 35437952
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
The regular overconsumption of energy-dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently exc…
Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in The…
PMID: 35360442
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Bile acids help maintain the physiological balance of the gut microbiome and the integrity of the intestinal epithelial barrier. Similarl…
PLA(2)-Triggered Activation of Cyclosporine-Phospholipid Prodrug as a Drug Targ…
PMID: 35336048
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 6.3
Oral medication with activity specifically at the inflamed sites throughout the gastrointestinal tract and limited systemic exposure would be a major…
Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcera…
PMID: 35303235
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a low cure rate. Periplaneta americana is a traditional American Cockroach…
Mesenteric Adipose Tissue Contributes to Intestinal Fibrosis in Crohn's Disease…
PMID: 35104318
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND AND AIMS: Intestinal fibrostenosis is an important cause of surgical intervention in patients with Crohn's disease [CD]. Hypertrophic mese…
Cross-tissue transcriptome-wide association studies identify susceptibility gen…
PMID: 35058554
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Genetic correlations and an increased incidence of psychiatric disorders in inflammatory-bowel disease have been reported, but shared molecular mecha…
Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated Wi…
PMID: 34978330
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammatory bowel disease may arise with inadequate immune response to intestinal bacteria. NOD2 is an established gene in Crohn's disea…
Infliximab Efficacy May Be Linked to Full TNF-α Blockade in Peripheral Compartm…
PMID: 34834236
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
AIM: Many therapeutic options for inflammatory bowel disease (IBD) emerged during the last 2 decades, along with the rise in disease prevalence and …
Clinical approach to skin eruptions induced by anti-TNF agents among patients w…
PMID: 34777576
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic relapsing intestinal inflammations with increasing global incidence, and new drug developm…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||