| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
Prebiotic selection influencing inflammatory bowel disease treatment outcomes: …
PMID: 39944472
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is characterised by chronic inflammation in the gastrointestinal tract, with unclear aetiology but with known factor…
VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase…
PMID: 39899477
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory disease of gastroenteric tissue characterized by episodes…
Phenotype-Led Identification of IL-10 Upregulators in Human CD4(+) T-cells and …
PMID: 39780505
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
Therapeutics promoting the endogenous production of IL-10 have the potential to restore homeostasis in inflammatory disorders such as inflammatory bo…
L-Arginine-Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatm…
PMID: 39763139
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS…
Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviat…
PMID: 39378068
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of t…
Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and …
PMID: 39081086
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Small-interfering RNAs (siRNAs) offer promising prospects for treating pyroptosis-related autoimmune diseases. However, poor stability and off-target…
Attenuation of Colitis-Induced Visceral Hypersensitivity and Pain by Selective …
PMID: 38478397
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to a…
Identification of highly selective SIK1/2 inhibitors that modulate innate immun…
PMID: 38147543
Year: 2024
Relationship Type:
Target Validation
Score: 5.3
The salt-inducible kinases (SIK) 1-3 are key regulators of pro- versus anti-inflammatory cytokine responses during innate immune activation. The lack…
Preparation and evaluation of radiolabeled acetaminosalol microspheres: A new p…
PMID: 37935385
Year: 2024
Relationship Type:
Correlation Studies
Score: 5.3
Acetaminosalol labeling reaction with technetium-99m was optimized, and the radiocomplex was obtained in a high radiochemical yield of 98.9 +/- 0.6% …
P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphing…
PMID: 37461948
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Amiselimod is a selective sphingosine 1-phosphate receptor modulator in development for inflammatory bowel disease. It is converted to it…
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
PMID: 37427891
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
TYK2 is a key mediator of IL12, IL23, and type I interferon signaling, and these cytokines have been implicated in the pathogenesis of multiple infla…
Oral Hydrogel Microbeads-Mediated In Situ Synthesis of Selenoproteins for Regul…
PMID: 37208802
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as a protein drug that is easily denatured or degraded in th…
Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithe…
PMID: 37107231
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Selenoprotein W (Selenow) is a ~9 kDa selenoprotein suggested to play a beneficial role in resolving inflammation. However, the underlying mechanisms…
Efficacy of Filgotinib in Patients with Ulcerative Colitis by Line of Therapy i…
PMID: 36928705
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: The efficacy of new therapies for ulcerative colitis [UC] is usually influenced by previous biologic use. These post hoc analyse…
Synthesis, Characterization of Low Molecular Weight Chitosan Selenium Nanoparti…
PMID: 36555167
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Selenium nanoparticles have attracted extensive attention due to their good bioavailability and activity. In the present study, a new form of seleniu…
A Matching Strategy To Guide Donor Selection for Ulcerative Colitis in Fecal Mi…
PMID: 36472435
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
Fecal microbiota transplantation (FMT) targeting gut microbiota has recently been applied to the treatment of ulcerative colitis (UC). However, preli…
Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural…
PMID: 36370291
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Balancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic …
On-demand reconstitutable hyaluronic acid-doped azathioprine microcrystals effe…
PMID: 36178247
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Although CD44-targeted delivery of pure drug microcrystals of azathioprine (AZA) could be a desirable approach to treat ulcerative colitis (UC), prem…
Pretreatment with millet-derived selenylated soluble dietary fiber ameliorates …
PMID: 36159466
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory activation and intestinal flora imbalance play key roles in the development and progression of inflammatory bowel disease (IBD). Soluble…
ILC3s select microbiota-specific regulatory T cells to establish tolerance in t…
PMID: 36071169
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but the mechanisms controlling these distinct…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||