| Abstract: | The aim of the study was to establish the relationship between anthropometric characteristics, lipid-carbohydrate metabolism parameters, endothelial lipase (EL) levels of blood serum depending on the degree of liver steatosis in patients with non-alcoholic fatty liver disease and hypertension. 60 patients with NAFLD on the background of hypertension and overweight were examined. The examined patients were divided into three groups: with hypertension without increasing the NAFLD liver fat score (group 1, n = 16), with steatosis on the background of hypertension (group 2, n = 20), with steatosis with hypertension and with laboratory signs of steatohepatitis (group 3, n = 24). All patients were divided with accordance of age and sex. The contol group consisted of 20 healthy individuals. To identify liver steatosis, NAFLD liver fat score was used according to the formula: NAFLD liver fat score = - 2.89 + 1.18 × Metabolic syndrome (yes = 1/no = 0) + 0.45 × type 2 DM (yes = 2/no = 0) + 0.15 × insulin (mU /L) + 0.04 × AST (U/L) - 0.94 × AST/ALT. The concentration of EL serum was determined by ELISA method using Aviscera Bioscience INC reagents kit (USA). The study revealed a significant difference in groups of surrogate coefficient hepatic steatosis (NAFLD liver fat score), which also takes into account the sensitivity to insulin, significantly (SS effect 27,39; MS effect 13,69; F = 6,73; p = 0,002) increases from group to group with steatosis to steatohepatitis. In patients with steatohepatitis, the expression of abdominal fatty deposits is greater than in those who have steatosis. Thus, simultaneously with increasing BMI and abdominal fat deposition, significantly increases the concentration of triglycerides, LDL, and VLDL. The concentration of EL, which is involved in the metabolism of HDL, is lowest in patients of the control group (does not exceed 10 mmol / l) and increases progressively with steatosis with hypertension and with steatohepatitis compared with those suffering from hypertension without steatosis. In addition, an increase in EL is associated with the presence of metabolic disorders, which, in aggregate, makes it possible to attribute it to independent markers of the atherosclerotic process and cardiovascular risk. |
