Research Article Details
| Article ID: | A13460 |
| PMID: | 29962430 |
| Source: | J Nutr Sci Vitaminol (Tokyo) |
| Title: | L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice. |
| Abstract: | Non-alcoholic hepatic steatosis is a phenotype of metabolic syndrome, and aging is a risk factor for this condition. Senescence-accelerated mouse prone 8 (SAMP8) is a murine model for studying aging-associated disorders. We here investigated the effect of dietary supplementation with L-lysine (Lys) on non-alcoholic hepatic steatosis in SAMP8 mice. Triglyceride (TG) and cholesterol (Chol) accumulated in the livers of SAMP8 mice fed a standard diet at 36 wk of age. However, intake of a Lys-rich diet for 2 mo prevented the accumulation of TG and Chol in the liver. Plasma alanine aminotransferase activity, an index of liver injury, was decreased by Lys. The mRNA expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-α and carnitine palmitoyltransferase 1a, which regulate β-oxidation, were increased in the livers of SAMP8 mice fed the Lys-rich diet. Taken together, our study suggests dietary intake of Lys prevents hepatic steatosis by stimulating β-oxidation in SAMP8 mice. |
| DOI: | 10.3177/jnsv.64.192 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T18 | Acetyl-CoA carboxylase 1 | ACACA | inhibitor | Enzyme | Q13085 | ACACA_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D579 | Emfilermin | Miscellany | -- | adipocytes | Enhance lipid metabolism | Under investigation | Details |
| D581 | sobetirome | Chemical drug | -- | Thyroid hormone receptor beta agonists | Enhance lipid metabolism | Under investigation | Details |
| D199 | L-alanine | Chemical drug | DB00160 | KYNU | -- | Failed in clinical trials | Details |
| D201 | L-Carnitine | Supplement | DB00583 | SLC22A4; SLC22A5; CRAT; MPO | -- | Under clinical trials | Details |
| D316 | S-adenosyl-L-methionine | Chemical drug | DB00118 | GNMT cofactor | Antiviral | Under clinical trials | Details |
| D062 | Carnitine complex | Supplement | DB00583 | SLC22A4; SLC22A5; CRAT; MPO | -- | Under clinical trials | Details |