Research Article Details
| Article ID: | A24045 |
| PMID: | 23285761 |
| Source: | Klin Med (Mosk) |
| Title: | [The prevalence of liver and gallbladder pathologies in overweight and obese patients]. |
| Abstract: | This paper reports data on the prevalence of liver and gallbladder pathologies in ovenrweight and obese patients based on the examination of 1506 subjects (684 men, 820 women) aged 25-65 years. Changes in the liver and gall bladder constituted principal pathology of the gastrointestinal tract associated with excessive body mass and obesity. Body mass index (BMI) positively correlated with triglyceride, VLDLP and HDLP cholesterol levels (p = 0.001). 39.5% of the obese patients had elevated plasma triglyceride levels. Insulin resistance was diagnosed in 76% of the patients with morbid obesity (56.2% in grade II obesity and 51.4 in grade I obesity vs. 15.2% in controls). The occumrrence of insulin iresistance increased with BMI (p = 0.0001). Nonalcoholic fatty liver disease was diagnosed using hepatic elastography and senrum markers (FibroMax and SteatoScreen tests). Non-alcoholic steatohepatitis was foumnd in 6.74% of the overweight patients and in 13.1% of those with obesity The occurrence of this condition in obese patients increased with BMI (10.1, 14.3. 14.9% in grade I, II and III obesity respectively). 6.7% of the patients with excessive body mass and 11.6% with obesity had signs of cholelithiasis in their medical histories. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I03 | 10211 | Cholelithiasis | cholelithiasis | disease of anatomical entity/gastrointestinal system disease/gallbladder disease | Details |
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |