Research Article Details
| Article ID: | A47155 |
| PMID: | 24793348 |
| Source: | J Clin Lipidol |
| Title: | Association between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia. |
| Abstract: | BACKGROUND: Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis. OBJECTIVE: To study the association of alcoholic intake, overweight, and dyslipidemia. METHODS: We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol. RESULTS: The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05). CONCLUSIONS: Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C). |
| DOI: | 10.1016/j.jacl.2014.02.003 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |
| I13 | 3146 | Lipid metabolism disorder | An inherited metabolic disorder that involves the creation and degradation of lipids. http://en.wikipedia.org/wiki/Lipid_metabolism | disease of metabolism/ inherited metabolic disorder | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| I07 | 1936 | Arteriosclerosis | Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35768 | disease of anatomical entity/cardiovascular system disease/ vascular disease/ artery disease | Details |