Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21193 | 25488932 | Drug Metab Dispos | Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis. | 2014 | Details |
| A21220 | 25470250 | PLoS One | Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. | 2014 | Details |
| A21229 | 25469013 | World J Gastroenterol | Obesity, fatty liver disease and intestinal microbiota. | 2014 | Details |
| A21240 | 25460293 | Horm Mol Biol Clin Investig | Nutrition: a promising route for prevention and management of obesity-related nonalcoholic fatty liver disease. | 2014 | Details |
| A21257 | 25451254 | Biochem Biophys Res Commun | Apolipoprotein A-I expression suppresses COX-2 expression by reducing reactive oxygen species in hepatocytes. | 2014 | Details |
| A21263 | 25450212 | J Hepatol | Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity. | 2014 | Details |
| A21268 | 25445436 | Life Sci | Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice. | 2014 | Details |
| A21272 | 25443620 | Liver Int | The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation. | 2015 | Details |
| A21294 | 25428903 | Am J Physiol Gastrointest Liver Physiol | Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. | 2014 | Details |
| A21303 | 25421042 | Mol Med Rep | Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model. | 2014 | Details |
| A21322 | 25406833 | J Transl Med | Hepatoprotective and antioxidant activities of extracts from Salvia-Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice. | 2014 | Details |
| A21364 | 25372401 | PLoS One | Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. | 2014 | Details |
| A21402 | 25347994 | J Pharmacol Exp Ther | M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice. | 2014 | Details |
| A21419 | 25333350 | Mol Med Rep | Inhibition of aldose reductase ameliorates diet-induced nonalcoholic steatohepatitis in mice via modulating the phosphorylation of hepatic peroxisome proliferator-activated receptor α. | 2014 | Details |
| A21424 | 25330059 | Cell Transplant | Preoperative hepatocyte transplantation improves the survival of rats with nonalcoholic steatohepatitis-related cirrhosis after partial hepatectomy. | 2014 | Details |
| A21433 | 25320186 | J Nutr | Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women. | 2014 | Details |
| A21441 | 25316683 | JPEN J Parenter Enteral Nutr | Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice. | 2014 | Details |
| A21477 | 25294219 | Toxicol Sci | Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice. | 2014 | Details |
| A21488 | 25281898 | Int Immunopharmacol | 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. | 2014 | Details |
| A21489 | 25281863 | J Hepatol | Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. | 2014 | Details |
| A21497 | 25274101 | Br J Nutr | Non-alcoholic fatty liver disease: need for a balanced nutritional source. | 2014 | Details |
| A21502 | 25270373 | Acta Radiol | High resolution in vivo 31P-MRS of the liver: potential advantages in the assessment of non-alcoholic fatty liver disease. | 2014 | Details |
| A21503 | 25269746 | Mol Med Rep | Upregulated microRNA-199a-5p inhibits nuclear receptor corepressor 1 translation in mice with non‑alcoholic steatohepatitis. | 2014 | Details |
| A21521 | 25256357 | J Nutr Biochem | Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism. | 2014 | Details |
| A21522 | 25256142 | J Cell Mol Med | ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease. | 2014 | Details |
| A21656 | 25145655 | Toxicol Sci | Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat. | 2014 | Details |
| A21683 | 25122558 | FASEB J | Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis. | 2014 | Details |
| A21733 | 25083607 | Gastroenterology | Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. | 2014 | Details |
| A21741 | 25080921 | Toxicol Sci | Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis. | 2014 | Details |
| A21763 | 25063232 | Int J Biochem Cell Biol | Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis. | 2014 | Details |
| A21765 | 25061561 | Mol Metab | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. | 2014 | Details |
| A21776 | 25051256 | Mol Med Rep | Protective effects and mechanisms of total alkaloids of Rubus alceaefolius Poir on non‑alcoholic fatty liver disease in rats. | 2014 | Details |
| A21781 | 25048951 | J Hepatol | CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. | 2014 | Details |
| A21796 | 25040043 | Liver Int | microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis. | 2014 | Details |
| A21821 | 25024595 | World J Gastroenterol | Experimental models of non-alcoholic fatty liver disease in rats. | 2014 | Details |
| A21838 | 25011936 | Gut | Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease. | 2014 | Details |
| A21861 | 24993337 | Int J Mol Med | Exendin‑4, a glucagon‑like peptide‑1 receptor agonist, modulates hepatic fatty acid composition and Δ‑5‑desaturase index in a murine model of non‑alcoholic steatohepatitis. | 2014 | Details |
| A21875 | 24987492 | Oxid Med Cell Longev | Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study. | 2014 | Details |
| A21896 | 24975216 | J Nutr Sci Vitaminol (Tokyo) | Retinol status and expression of retinol-related proteins in methionine-choline deficient rats. | 2014 | Details |
| A21947 | 24946279 | J Hepatol | ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. | 2014 | Details |
| A21952 | 24941342 | Molecules | Standardized Salvia miltiorrhiza extract suppresses hepatic stellate cell activation and attenuates steatohepatitis induced by a methionine-choline deficient diet in mice. | 2014 | Details |
| A21956 | 24937020 | Eur J Pharmacol | Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. | 2014 | Details |
| A21979 | 24918580 | PLoS One | Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice. | 2014 | Details |
| A22008 | 24895482 | J Clin Biochem Nutr | The α-tocopherol status and expression of α-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E. | 2014 | Details |
| A22031 | 24865256 | Dig Dis Sci | Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet. | 2014 | Details |
| A22036 | 24861026 | J Mol Med (Berl) | NLRP3 inflammasome activation is required for fibrosis development in NAFLD. | 2014 | Details |
| A22039 | 24857839 | Arch Biochem Biophys | Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis. | 2014 | Details |
| A22045 | 24853141 | PLoS One | HCC development is associated to peripheral insulin resistance in a mouse model of NASH. | 2014 | Details |
| A22054 | 24849253 | PLoS One | Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes. | 2014 | Details |
| A22061 | 24845607 | J Hepatol | Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice. | 2014 | Details |
| A22082 | 24830603 | Exp Mol Pathol | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Details |
| A22138 | 24795036 | Dig Dis Sci | Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. | 2014 | Details |
| A22210 | 24747563 | Biochem Biophys Res Commun | Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis. | 2014 | Details |
| A22216 | 24743734 | Cell Death Dis | Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. | 2014 | Details |
| A22250 | 24719358 | FASEB J | Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis. | 2014 | Details |
| A22258 | 24714086 | Int J Mol Sci | Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma. | 2014 | Details |
| A22263 | 24708244 | Endocrinology | GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency. | 2014 | Details |
| A22270 | 24702805 | Chin J Nat Med | Effect of Trifolium pratense extract on methionine-choline-deficient diet-induced steatohepatitis in C57BL/6 mice. | 2014 | Details |
| A22317 | 24668763 | Hepatology | Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. | 2014 | Details |
| A22335 | 24652102 | J Gastroenterol | The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. | 2014 | Details |
| A22343 | 24650018 | Liver Int | Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. | 2014 | Details |
| A22382 | 24628836 | Liver Int | n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis. | 2014 | Details |
| A22392 | 24622832 | J Physiol Pharmacol | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up. | 2014 | Details |
| A22401 | 24613363 | J Hepatol | Synergistic interaction between genetics and disease on pravastatin disposition. | 2014 | Details |
| A22417 | 24595150 | J Int Med Res | Fatty liver and serum cholinesterase are independently correlated with HbA1c levels: cross-sectional analysis of 5384 people. | 2014 | Details |
| A22418 | 24594481 | Biochim Biophys Acta | Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). | 2014 | Details |
| A22487 | 24520780 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Treatment of nonalcoholic steatohepatitis by Jianpi Shugan Recipe: a multi-center, randomized, controlled clinical trial]. | 2014 | Details |
| A22489 | 24520264 | Exp Ther Med | Comparison between the efficacies of curcumin and puerarin in C57BL/6 mice with steatohepatitis induced by a methionine- and choline-deficient diet. | 2013 | Details |
| A22519 | 24495527 | Proc Nutr Soc | 'The way to a man's heart is through his gut microbiota'--dietary pro- and prebiotics for the management of cardiovascular risk. | 2014 | Details |
| A22521 | 24492979 | Surg Today | Hydrolyzed whey peptide-based diet ameliorates hepatic ischemia-reperfusion injury in the rat nonalcoholic fatty liver. | 2014 | Details |
| A22533 | 24486698 | Mol Cell Endocrinol | Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: an experimental study in the rabbit. | 2014 | Details |
| A22539 | 24480733 | Arch Med Res | Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease. | 2014 | Details |
| A22553 | 24466347 | PLoS One | Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. | 2014 | Details |
| A22573 | 24454937 | PLoS One | Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. | 2014 | Details |
| A22583 | 24445049 | J Nutr Biochem | Sesame oil mitigates nutritional steatohepatitis via attenuation of oxidative stress and inflammation: a tale of two-hit hypothesis. | 2013 | Details |
| A22619 | 24403518 | J Pharmacol Exp Ther | Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression. | 2014 | Details |
| A22620 | 24402912 | J Cell Biochem | HIF-1α expression as a protective strategy of HepG2 cells against fatty acid-induced toxicity. | 2014 | Details |
| A22667 | 24375162 | Iran Biomed J | Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. | 2014 | Details |
| A22679 | 26417275 | EXCLI J | Non-alcoholic fatty liver disease, diet and gut microbiota. | 2014 | Details |
| A22705 | 24368431 | J Nutr | Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet. | 2013 | Details |
| A22728 | 24353111 | Biofactors | Novel insights on interactions between folate and lipid metabolism. | 2013 | Details |
| A22753 | 24329600 | J Gastroenterol Hepatol | Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency. | 2014 | Details |
| A22760 | 24325816 | BMB Rep | The expression and secretion of vimentin in the progression of non-alcoholic steatohepatitis. | 2014 | Details |
| A22761 | 24325457 | J Med Food | The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD. | 2013 | Details |
| A22775 | 24316518 | J Hepatol | Dietary glycotoxins exacerbate progression of experimental fatty liver disease. | 2013 | Details |
| A22799 | 24295779 | Biochim Biophys Acta | Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice. | 2014 | Details |
| A22801 | 24294355 | Int J Clin Exp Pathol | Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice. | 2013 | Details |
| A22805 | 24291241 | J Hepatol | Non-alcoholic fatty liver disease: spectral patterns observed from an in vivo phosphorus magnetic resonance spectroscopy study. | 2013 | Details |
| A22847 | 24274865 | Clin Liver Dis | Obesity and NAFLD: the role of bacteria and microbiota. | 2013 | Details |
| A22853 | 24251710 | J Gastroenterol Hepatol | Role of diet and nutritional management in non-alcoholic fatty liver disease. | 2013 | Details |
| A22914 | 24217942 | J Appl Toxicol | Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis. | 2013 | Details |
| A22931 | 24197250 | J Gastroenterol | Combination of sorafenib and angiotensin-II receptor blocker attenuates preneoplastic lesion development in a non-diabetic rat model of steatohepatitis. | 2013 | Details |
| A22939 | 24190226 | Int J Mol Med | Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats. | 2013 | Details |
| A22953 | 24179615 | World J Hepatol | Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. | 2013 | Details |
| A22971 | 24157968 | Am J Physiol Gastrointest Liver Physiol | Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. | 2013 | Details |
| A22995 | 24130212 | Hum Exp Toxicol | Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease. | 2013 | Details |
| A23012 | 24117897 | J Gastroenterol Hepatol | Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats. | 2014 | Details |
| A23016 | 24115128 | Hepatology | Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. | 2014 | Details |
| A23020 | 24113768 | Am J Physiol Gastrointest Liver Physiol | Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model. | 2013 | Details |
| A23041 | 24084163 | Mol Genet Metab | Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. | 2013 | Details |