Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A16053 | 28593184 | Cell Mol Gastroenterol Hepatol | Epigenetics and Liver Fibrosis. | 2017 | Details |
| A16076 | 28581362 | Future Cardiol | PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ. | 2017 | Details |
| A16077 | 28581332 | Future Cardiol | PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α. | 2017 | Details |
| A16083 | 28578672 | Lipids Health Dis | Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice. | 2017 | Details |
| A16087 | 28577437 | Int Immunopharmacol | Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. | 2017 | Details |
| A16095 | 28573069 | World J Gastrointest Pathophysiol | Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. | 2017 | Details |
| A16129 | 28549240 | J Nutr Biochem | Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats. | 2017 | Details |
| A16131 | 28546081 | Pharmacol Ther | Targeting nuclear receptors for the treatment of fatty liver disease. | 2017 | Details |
| A16146 | 28539716 | Pharmacogn Mag | Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. | 2017 | Details |
| A16161 | 28529818 | J Diabetes Metab | High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice; association with diet/genetics-regulated micro-RNAs. | 2016 | Details |
| A16163 | 28529649 | Theranostics | SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway. | 2017 | Details |
| A16169 | 28526925 | Eur J Nutr | Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells. | 2017 | Details |
| A16175 | 28521870 | Metabolism | The use of statins alone, or in combination with pioglitazone and other drugs, for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and related cardiovascular risk. An Expert Panel Statement. | 2017 | Details |
| A16182 | 28514835 | Biomed Pharmacother | Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats. | 2017 | Details |
| A16205 | 28507283 | Med Sci Monit | MiR-149 Compromises the Reactions of Liver Cells to Fatty Acid via its Polymorphism and Increases Non-Alcoholic Fatty Liver Disease (NAFLD) Risk by Targeting Methylene Tetrahydrofolate Reductase (MTHFR). | 2017 | Details |
| A16233 | 28494548 | Zhonghua Gan Zang Bing Za Zhi | [The role of cytochrome P450 in nonalcoholic fatty liver induced by high-fat diet: a gene expression profile analysis]. | 2017 | Details |
| A16245 | 28486193 | Biomed Pharmacother | Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. | 2017 | Details |
| A16268 | 28476236 | Endocrinol Metab Clin North Am | Genetics of Lipodystrophy. | 2017 | Details |
| A16338 | 28449094 | Hum Mol Genet | Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. | 2017 | Details |
| A16339 | 28448552 | PLoS One | Transcriptomic analysis of the hepatic response to stress in the red cusk-eel (Genypterus chilensis): Insights into lipid metabolism, oxidative stress and liver steatosis. | 2017 | Details |
| A16347 | 28445156 | Oncotarget | Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice. | 2017 | Details |
| A16348 | 28443804 | J Am Coll Nutr | 25(OH)D Levels in Relation to Gender, Overweight, Insulin Resistance, and Inflammation in a Cross-Sectional Cohort of Northern Italian Workers: Evidence in Support of Preventive Health Care Programs. | 2017 | Details |
| A16361 | 28437865 | Hepatology | A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). | 2017 | Details |
| A16364 | 28436456 | Sci Rep | Synthesis and anti-obesity effects in vivo of Crotadihydrofuran C as a novel PPARγ antagonist from Crotalaria albida. | 2017 | Details |
| A16374 | 28429344 | Eur Rev Med Pharmacol Sci | Up-regulation of microRNA-367 promotes liver steatosis through repressing TBL1 in obese mice. | 2017 | Details |
| A16377 | 28428362 | J Endocrinol | Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. | 2017 | Details |
| A16405 | 28414763 | PLoS One | Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. | 2017 | Details |
| A16406 | 28414138 | Biochem Pharmacol | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Details |
| A16407 | 28414056 | Eur J Pharmacol | Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A16409 | 28412824 | Arch Iran Med | Assessment of Lean Patients with Non-alcoholic Fatty Liver Disease in a Middle Income Country; Prevalence and Its Association with Metabolic Disorders: A Cross-sectional Study. | 2017 | Details |
| A16414 | 28406477 | Cell Death Dis | miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. | 2017 | Details |
| A16423 | 28402022 | J Cell Biochem | Steroidogenic Acute Regulatory Protein (StAR) Overexpression Reduces Inflammation and Insulin Resistance in Obese Mice. | 2017 | Details |
| A16442 | 28386616 | Food Funct | Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. | 2017 | Details |
| A16443 | 28384519 | J Nutr Biochem | Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers. | 2017 | Details |
| A16473 | 28368286 | J Clin Invest | Distinct but complementary contributions of PPAR isotypes to energy homeostasis. | 2017 | Details |
| A16487 | 28359088 | Endocrinology | Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development. | 2017 | Details |
| A16495 | 28356106 | Lipids Health Dis | Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. | 2017 | Details |
| A16518 | 28344991 | Mol Ther Methods Clin Dev | Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes. | 2016 | Details |
| A16527 | 28335388 | Nutrients | A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats. | 2017 | Details |
| A16528 | 28335383 | Int J Mol Sci | A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets. | 2017 | Details |
| A16542 | 28325277 | Mol Ther Nucleic Acids | Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice. | 2016 | Details |
| A16562 | 28315901 | Med Sci Monit | The Effect of Sitagliptin on Lipid Metabolism of Fatty Liver Mice and Related Mechanisms. | 2017 | Details |
| A16566 | 28303724 | Drug Metab Rev | Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. | 2017 | Details |
| A16569 | 28300213 | Sci Rep | Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease. | 2017 | Details |
| A16614 | 28282876 | Int J Mol Sci | Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E. | 2017 | Details |
| A16629 | 28275212 | Int J Mol Sci | Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis. | 2017 | Details |
| A16638 | 28271032 | Mol Metab | Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16658 | 28260764 | Mymensingh Med J | Sonographically Detected Non Alcoholic Fatty Liver Disease in Apparently Healthy Adults and Associated Factors. | 2017 | Details |
| A16673 | 28253210 | Eur J Gastroenterol Hepatol | The association of nonalcoholic fatty liver disease with genetic polymorphisms: a multicenter study. | 2017 | Details |
| A16706 | 28232454 | Am J Physiol Gastrointest Liver Physiol | A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition. | 2017 | Details |
| A16709 | 28231052 | Acta Pharm | Review. The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease. | 2017 | Details |
| A16715 | 28225568 | J Magn Reson Imaging | Liver histology and diffusion-weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study. | 2017 | Details |
| A16729 | 28219837 | J Nutr Biochem | Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring. | 2017 | Details |
| A16732 | 28218651 | Int J Mol Sci | Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. | 2017 | Details |
| A16758 | 28202906 | Sci Rep | BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. | 2017 | Details |
| A16762 | 28195199 | Sci Rep | Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis. | 2017 | Details |
| A16771 | 28190475 | Phytomedicine | Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor. | 2016 | Details |
| A16795 | 28169366 | Sci Rep | Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. | 2017 | Details |
| A16820 | 28153707 | Biochim Biophys Acta Mol Basis Dis | Interleukin-17A exacerbates high-fat diet-induced hepatic steatosis by inhibiting fatty acid β-oxidation. | 2017 | Details |
| A16825 | 28146130 | Nutrients | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A16827 | 28144388 | World J Hepatol | Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade. | 2017 | Details |
| A16843 | 28132721 | Immunobiology | Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation. | 2017 | Details |
| A16844 | 28131861 | Toxicology | Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis. | 2017 | Details |
| A16847 | 28128372 | Food Funct | The hepatoprotective effect of Phyllanthus emblica L. fruit on high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in SD rats. | 2017 | Details |
| A16874 | 28115925 | PPAR Res | PPARs and Mitochondrial Metabolism: From NAFLD to HCC. | 2016 | Details |
| A16880 | 28112681 | J Clin Invest | Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. | 2017 | Details |
| A16910 | 28098910 | Mol Med Rep | Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ. | 2017 | Details |
| A16936 | 28084058 | J Diabetes Investig | Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice. | 2017 | Details |
| A16944 | 28081181 | PLoS One | Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation. | 2017 | Details |
| A16951 | 28077274 | Biochimie | The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. | 2017 | Details |
| A16964 | 28073164 | Hepatology | Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice. | 2017 | Details |
| A16971 | 28069746 | Postgrad Med J | Non-alcoholic fatty pancreas disease. | 2017 | Details |
| A17004 | 28052626 | Liver Int | Therapies in non-alcoholic steatohepatitis (NASH). | 2017 | Details |
| A17011 | 28051126 | Sci Rep | Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. | 2017 | Details |
| A17015 | 28044208 | J Gastroenterol | Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis. | 2017 | Details |
| A17039 | 28035771 | Hepatology | Hepatitis B virus infection and decreased risk of nonalcoholic fatty liver disease: A cohort study. | 2016 | Details |
| A17066 | 28012135 | Lipids | Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17073 | 28007783 | FASEB J | Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. | 2016 | Details |
| A17078 | 28003715 | J Clin Exp Hepatol | High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice. | 2016 | Details |
| A17087 | 27998724 | Am J Pathol | Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. | 2016 | Details |
| A17089 | 27997977 | Semin Liver Dis | Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin. | 2016 | Details |
| A17091 | 27996362 | Toxicol Mech Methods | The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level. | 2017 | Details |
| A17114 | 27984800 | Biomed Pharmacother | Saponins from the roots of Platycodon grandiflorum ameliorate high fat diet-induced non-alcoholic steatohepatitis. | 2016 | Details |
| A17119 | 27982131 | Sci Rep | CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα. | 2016 | Details |
| A17125 | 27979751 | J Hepatol | PARP1-mediated PPARα poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. | 2016 | Details |
| A17132 | 27973757 | Clin Exp Pharmacol Physiol | Alleviative effect of ciliary neurotrophic factor analogue on high fat-induced hepatic steatosis is partially independent of the central regulation. | 2017 | Details |
| A17136 | 27973423 | Nutrients | Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet. | 2016 | Details |
| A17143 | 27959936 | PLoS One | A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice. | 2016 | Details |
| A17154 | 27956025 | Nutr Metab Cardiovasc Dis | Sex differences in the impact of nonalcoholic fatty liver disease on cardiovascular risk factors. | 2016 | Details |
| A17164 | 27938560 | Zhonghua Gan Zang Bing Za Zhi | [Effect of targeted inhibition of hypoxia-inducible factor-1α by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole on the progression of non-alcoholic fatty liver disease in rats]. | 2016 | Details |
| A17175 | 27930988 | Biomed Pharmacother | Potential involvement of PPAR α activation in diminishing the hepatoprotective effect of fenofibrate in NAFLD: Accuracy of non- invasive panel in determining the stage of liver fibrosis in rats. | 2016 | Details |
| A17196 | 27917591 | Diabetes Obes Metab | The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. | 2017 | Details |
| A17202 | 27916647 | Biochimie | PPARs and nonalcoholic fatty liver disease. | 2016 | Details |
| A17216 | 27908750 | Transl Res | Mesenchymal stromal cell-based therapies reduce obesity and metabolic syndromes induced by a high-fat diet. | 2016 | Details |
| A17251 | 27889747 | Cell Physiol Biochem | Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. | 2016 | Details |
| A17310 | 27855315 | J Nutr Biochem | Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high-fat-diet-induced obese mice. | 2016 | Details |
| A17324 | 27845265 | J Ethnopharmacol | The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells. | 2016 | Details |
| A17336 | 27836672 | Biochem Pharmacol | Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis. | 2016 | Details |
| A17352 | 27828718 | J Med Food | 5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice. | 2016 | Details |