Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A24485 | 22847887 | Liver Transpl | Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. | 2012 | Details |
| A24492 | 22843123 | Endocrine | Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development. | 2012 | Details |
| A24509 | 22824481 | Clin Liver Dis | Can NASH be diagnosed, graded, and staged noninvasively? | 2012 | Details |
| A24510 | 22824480 | Clin Liver Dis | Mechanisms of disease progression in NASH: new paradigms. | 2012 | Details |
| A24525 | 22809102 | Annu Rev Nutr | Endoplasmic reticulum stress in nonalcoholic fatty liver disease. | 2012 | Details |
| A24566 | 22742931 | J Gastroenterol Hepatol | Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma. | 2012 | Details |
| A24567 | 22742899 | Eur J Pharmacol | Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. | 2012 | Details |
| A24600 | 22706738 | Turk J Gastroenterol | Effects of probiotics on methionine choline deficient diet-induced steatohepatitis in rats. | 2012 | Details |
| A24610 | 22692588 | Int J Mol Med | Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. | 2012 | Details |
| A24611 | 22692288 | Adv Anat Pathol | Liver biopsy in modern clinical practice: a pediatric point-of-view. | 2012 | Details |
| A24619 | 22684858 | Hepatology | Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. | 2012 | Details |
| A24621 | 22683933 | Toxicol In Vitro | Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. | 2012 | Details |
| A24650 | 22648540 | Histol Histopathol | Farnesoid X Receptor (FXR) from normal to malignant state. | 2012 | Details |
| A24664 | 22641095 | J Hepatol | p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice. | 2012 | Details |
| A24665 | 22641094 | J Hepatol | A hedgehog survival pathway in 'undead' lipotoxic hepatocytes. | 2012 | Details |
| A24688 | 22609053 | Trends Endocrinol Metab | Role of ceramides in nonalcoholic fatty liver disease. | 2012 | Details |
| A24703 | 22582214 | J Appl Physiol (1985) | Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease. | 2012 | Details |
| A24712 | 22570745 | Gut Liver | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Details |
| A24717 | 22567408 | Int J Hepatol | Mechanisms and biomarkers of apoptosis in liver disease and fibrosis. | 2012 | Details |
| A24740 | 22546234 | Eur J Pharmacol | Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes. | 2012 | Details |
| A24744 | 22544329 | Cell Cycle | The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. | 2012 | Details |
| A24751 | 22537612 | Gastroenterology | Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. | 2012 | Details |
| A24779 | 22505328 | Hepatology | Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. | 2012 | Details |
| A24818 | 22467277 | Hepatology | Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease. | 2012 | Details |
| A24830 | 22455888 | Zhonghua Bing Li Xue Za Zhi | [Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet]. | 2012 | Details |
| A24839 | 22439844 | Clin Sci (Lond) | Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. | 2012 | Details |
| A24874 | 22418883 | Semin Liver Dis | Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research. | 2012 | Details |
| A24900 | 22380754 | BMC Gastroenterol | Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease. | 2012 | Details |
| A24910 | 22372457 | Histopathology | The epidemiology, pathogenesis and histopathology of fatty liver disease. | 2012 | Details |
| A24945 | 22320917 | J Gastroenterol Hepatol | Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis. | 2012 | Details |
| A24951 | 22326434 | Gastroenterology | Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. | 2012 | Details |
| A24968 | 22297845 | Nature | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. | 2012 | Details |
| A24970 | 22295101 | PLoS One | LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. | 2012 | Details |
| A25014 | 22246806 | Mol Cell Biochem | Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. | 2012 | Details |
| A25033 | 22228470 | J Cell Biochem | Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cells. | 2012 | Details |
| A25043 | 22221411 | Lipids Health Dis | Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells. | 2012 | Details |
| A25104 | 22168073 | Eksp Klin Gastroenterol | [Comparison of the immune response in patients with alcoholic liver disease and non-alcoholic steatohepatitis]. | 2011 | Details |
| A25119 | 22155365 | Gastroenterology | Autophagy protects cells from HCV-induced defects in lipid metabolism. | 2011 | Details |
| A25120 | 22155236 | Biochem Biophys Res Commun | Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model. | 2011 | Details |
| A25128 | 22152378 | Zhonghua Gan Zang Bing Za Zhi | [The role of Fas mutation on non-alcoholic steatohepatitis in mice]. | 2011 | Details |
| A25169 | 22118645 | Int J Exp Pathol | Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet. | 2011 | Details |
| A25179 | 22110476 | Exp Diabetes Res | Diagnosis and evaluation of nonalcoholic fatty liver disease. | 2011 | Details |
| A25187 | 22106162 | Orv Hetil | [Role of autophagy in the pathogenesis of liver diseases]. | 2011 | Details |
| A25209 | 22093454 | Liver Int | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. | 2011 | Details |
| A25244 | 22051117 | FEBS J | New insights into the functions and localization of nuclear transglutaminase 2. | 2011 | Details |
| A25256 | 22037452 | Biochem Biophys Res Commun | 17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30. | 2011 | Details |
| A25259 | 25346653 | Curr Pediatr Rev | Keratin 18, Apoptosis, and Liver Disease in Children. | 2011 | Details |
| A25294 | 21987620 | World J Gastroenterol | JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease. | 2011 | Details |
| A25321 | 21957486 | PLoS One | GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. | 2011 | Details |
| A25420 | 21875310 | Crit Rev Clin Lab Sci | Non-alcoholic fatty liver disease. | 2011 | Details |
| A25443 | 21836057 | Am J Physiol Gastrointest Liver Physiol | Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. | 2011 | Details |
| A25455 | 21814826 | J Mol Med (Berl) | Increased hepatic apoptosis in high-fat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance. | 2011 | Details |
| A25474 | 21793903 | J Gastroenterol Hepatol | Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways. | 2012 | Details |
| A25481 | 21787405 | Lipids Health Dis | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Details |
| A25490 | 21773018 | J Nutr Metab | Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients. | 2011 | Details |
| A25508 | 21742296 | Clin Res Hepatol Gastroenterol | Liver fibrogenesis and metabolic factors. | 2011 | Details |
| A25520 | 21748765 | Hepatology | Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. | 2011 | Details |
| A25539 | 21734787 | World J Gastroenterol | Adiponectin, a key adipokine in obesity related liver diseases. | 2011 | Details |
| A25569 | 21703998 | Gastroenterology | Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. | 2011 | Details |
| A25575 | 21703174 | J Hepatol | Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. | 2011 | Details |
| A25582 | 21690266 | J Lipid Res | Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. | 2011 | Details |
| A25609 | 21651352 | Expert Rev Gastroenterol Hepatol | Animal models in the study of hepatitis C virus-associated liver pathologies. | 2011 | Details |
| A25619 | 21635548 | APMIS | Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis. | 2011 | Details |
| A25625 | 21633093 | J Lipid Res | A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA. | 2011 | Details |
| A25627 | 21629127 | J Pediatr Gastroenterol Nutr | Mechanisms of lipotoxicity in NAFLD and clinical implications. | 2011 | Details |
| A25652 | 21592363 | Lipids Health Dis | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Details |
| A25657 | 21570964 | Exp Mol Pathol | A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. | 2011 | Details |
| A25662 | 21567402 | J Cell Physiol | Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways. | 2012 | Details |
| A25720 | 21508207 | J Nutr | Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats. | 2011 | Details |
| A25743 | 21488074 | Hepatology | Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. | 2011 | Details |
| A25745 | 21488066 | Hepatology | Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. | 2011 | Details |
| A25762 | 21476916 | Expert Rev Gastroenterol Hepatol | Cell death and nonalcoholic steatohepatitis: where is ballooning relevant? | 2011 | Details |
| A25763 | 21476915 | Expert Rev Gastroenterol Hepatol | Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. | 2011 | Details |
| A25788 | 21455726 | Diabetologia | Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. | 2011 | Details |
| A25822 | 21426695 | Zhonghua Er Ke Za Zhi | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. | 2011 | Details |
| A25859 | 21382273 | J Biol Regul Homeost Agents | Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease. | 2011 | Details |
| A25860 | 21382219 | Br J Nutr | Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A25886 | 21353887 | Vitam Horm | Activin A in nonalcoholic fatty liver disease. | 2011 | Details |
| A25897 | 21346097 | J Nutr | PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. | 2011 | Details |
| A25918 | 21328622 | Biofactors | Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. | 2010 | Details |
| A25919 | 21327921 | Dig Dis Sci | Correlation analysis between gene expression profile of rat liver tissues and high-fat emulsion-induced nonalcoholic fatty liver. | 2011 | Details |
| A25920 | 21327395 | Cell Tissue Res | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. | 2011 | Details |
| A26006 | 21216209 | Endocrinol Nutr | [Fatty liver and its clinical management in obese adolescents]. | 2011 | Details |
| A26020 | 22629789 | Eksp Klin Gastroenterol | [UDCA in the treatment of nonalcoholic fatty liver disease]. | 2011 | Details |
| A26021 | 22629725 | Eksp Klin Gastroenterol | [UDCA in the treatment of nonalcoholic fatty liver disease]. | 2011 | Details |
| A26031 | 21184788 | J Hepatol | Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. | 2010 | Details |
| A26034 | 21182485 | Curr Med Chem | Toward a biochemical diagnosis of NASH: insights from pathophysiology for distinguishing simple steatosis from steatohepatitis. | 2011 | Details |
| A26062 | 21147505 | J Hepatol | Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. | 2010 | Details |
| A26067 | 21145844 | J Hepatol | Endoplasmic reticulum stress in liver disease. | 2010 | Details |
| A26073 | 21145823 | J Hepatol | Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver. | 2010 | Details |
| A26076 | 21145805 | J Hepatol | An apoptosis panel for nonalcoholic steatohepatitis diagnosis. | 2011 | Details |
| A26085 | 21128705 | Antioxid Redox Signal | Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. | 2011 | Details |
| A26093 | 21115542 | Gut | Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. | 2010 | Details |
| A26099 | 21108736 | Liver Int | Decreased immunoexpression of survivin could be a potential marker in human non-alcoholic fatty liver disease progression? | 2010 | Details |
| A26116 | 21072891 | World J Gastroenterol | Histopathology of nonalcoholic fatty liver disease. | 2010 | Details |
| A26137 | 21042023 | Digestion | Obesity affects the liver - the link between adipocytes and hepatocytes. | 2010 | Details |
| A26165 | 20969475 | Antioxid Redox Signal | Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. | 2011 | Details |
| A26174 | 20956972 | Lab Invest | Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. | 2010 | Details |
| A26186 | 20939106 | World J Gastroenterol | Noninvasive investigations for non alcoholic fatty liver disease and liver fibrosis. | 2010 | Details |
| A26187 | 20939105 | World J Gastroenterol | Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. | 2010 | Details |