Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A17663 | 27679530 | J Biol Chem | Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. | 2016 | Details |
| A17704 | 27646933 | Gut | Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. | 2016 | Details |
| A17712 | 27640119 | Lipids Health Dis | Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease. | 2016 | Details |
| A17731 | 27632923 | Nutr Res | Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. | 2016 | Details |
| A17732 | 27632911 | Nutr Res | Cynanchum wilfordii Radix attenuates liver fat accumulation and damage by suppressing hepatic cyclooxygenase-2 and mitogen-activated protein kinase in mice fed with a high-fat and high-fructose diet. | 2016 | Details |
| A17733 | 27632189 | PLoS Comput Biol | A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD. | 2016 | Details |
| A17771 | 27609031 | Exp Mol Med | MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. | 2016 | Details |
| A17790 | 27589792 | Nutrients | Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. | 2016 | Details |
| A17802 | 27577854 | Am J Physiol Endocrinol Metab | Treatment of nonalcoholic fatty liver disease: role of AMPK. | 2016 | Details |
| A17806 | 27572914 | Sci Rep | Lack of association between SREBF-1c gene polymorphisms and risk of non-alcoholic fatty liver disease in a Chinese Han population. | 2016 | Details |
| A17825 | 27554471 | Diabetes | Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1. | 2016 | Details |
| A17830 | 27548720 | Dig Dis | Pathophysiology of Nonalcoholic Fatty Liver Disease: Lifestyle-Gut-Gene Interaction. | 2016 | Details |
| A17855 | 27522544 | Cell Mol Life Sci | Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β. | 2016 | Details |
| A17901 | 27487733 | Food Funct | Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A17918 | 27477676 | Biochim Biophys Acta | SCD1 deficiency protects mice against ethanol-induced liver injury. | 2016 | Details |
| A17948 | 27458503 | World J Hepatol | Lipogenesis in Huh7 cells is promoted by increasing the fructose: Glucose molar ratio. | 2016 | Details |
| A17953 | 27456850 | BMC Complement Altern Med | Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. | 2016 | Details |
| A17971 | 27445343 | Am J Physiol Gastrointest Liver Physiol | A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. | 2016 | Details |
| A17977 | 27439777 | Sci Rep | Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism. | 2016 | Details |
| A18027 | 27405060 | J Hepatol | Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors. | 2016 | Details |
| A18036 | 27393135 | Diabetologia | Effects of exercise training on intrahepatic lipid content in humans. | 2016 | Details |
| A18048 | 27384305 | Endocrinology | Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18064 | 27376874 | Transl Res | Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis. | 2016 | Details |
| A18069 | 27372863 | Med Hypotheses | Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance. | 2016 | Details |
| A18072 | 27368608 | Lipids Health Dis | Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. | 2016 | Details |
| A18083 | 27357269 | Mol Med Rep | Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells. | 2016 | Details |
| A18091 | 27354540 | Physiol Rep | Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet. | 2016 | Details |
| A18118 | 27343380 | Eur J Pharmacol | (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. | 2016 | Details |
| A18137 | 27325692 | J Biol Chem | XBP1s Is an Anti-lipogenic Protein. | 2016 | Details |
| A18139 | 27324067 | Metabolism | Nonalcoholic fatty liver disease and obstructive sleep apnea. | 2016 | Details |
| A18145 | 27322467 | EBioMedicine | Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis. | 2016 | Details |
| A18222 | 27276701 | Liver Int | Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? | 2016 | Details |
| A18247 | 27265384 | Life Sci | Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. | 2016 | Details |
| A18249 | 27264075 | Mol Cell Endocrinol | Zinc alpha2 glycoprotein alleviates palmitic acid-induced intracellular lipid accumulation in hepatocytes. | 2016 | Details |
| A18259 | 27260465 | J Nutr Biochem | A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway. | 2016 | Details |
| A18285 | 29879345 | Yao Xue Xue Bao | [Investigating the effects of compound WS090152 on non-alcoholic fatty liver in mice]. | 2016 | Details |
| A18288 | 27239734 | Lab Invest | C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. | 2016 | Details |
| A18306 | 27222915 | Ann Med | Liver fat accumulation is associated with circulating PCSK9. | 2016 | Details |
| A18307 | 27222533 | Gut | Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. | 2016 | Details |
| A18316 | 27216820 | Int J Obes (Lond) | Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver. | 2016 | Details |
| A18356 | 27184920 | Sci Rep | Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer. | 2016 | Details |
| A18357 | 27184670 | BMC Complement Altern Med | Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway. | 2016 | Details |
| A18364 | 27181051 | Sci Rep | Ces3/TGH Deficiency Attenuates Steatohepatitis. | 2016 | Details |
| A18365 | 27180240 | Toxicol Appl Pharmacol | Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. | 2016 | Details |
| A18372 | 27176782 | Mol Med Rep | Treatment with estrogen protects against ovariectomy-induced hepatic steatosis by increasing AQP7 expression. | 2016 | Details |
| A18391 | 27166182 | Oncotarget | Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1. | 2016 | Details |
| A18423 | 27145114 | Mol Nutr Food Res | Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obese mice. | 2016 | Details |
| A18501 | 27089331 | Int J Mol Sci | NAFLD and Chronic Kidney Disease. | 2016 | Details |
| A18510 | 27083512 | J Gastroenterol Hepatol | Adiponectin regulates aquaglyceroporin expression in hepatic stellate cells altering their functional state. | 2017 | Details |
| A18526 | 27069901 | Prev Nutr Food Sci | Ameliorative Effects of Pomegranate Peel Extract against Dietary-Induced Nonalcoholic Fatty Liver in Rats. | 2016 | Details |
| A18552 | 27061435 | J Cell Mol Med | miR-149 controls non-alcoholic fatty liver by targeting FGF-21. | 2016 | Details |
| A18559 | 27057275 | Oxid Med Cell Longev | Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis. | 2016 | Details |
| A18582 | 27048250 | Diabetologia | Hepatic glucose and lipid metabolism. | 2016 | Details |
| A18677 | 27002331 | PLoS One | Effect of Octreotide on Hepatic Steatosis in Diet-Induced Obesity in Rats. | 2016 | Details |
| A18680 | 27001282 | Nutr Res | Opuntia ficus-indica seed attenuates hepatic steatosis and promotes M2 macrophage polarization in high-fat diet-fed mice. | 2015 | Details |
| A18690 | 26997538 | Metabolism | Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. | 2016 | Details |
| A18728 | 26980302 | Toxicol Sci | Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis. | 2016 | Details |
| A18747 | 26972505 | J Ethnopharmacol | Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress. | 2016 | Details |
| A18752 | 26971824 | Gastroenterology | Perspectives on Treatment for Nonalcoholic Steatohepatitis. | 2016 | Details |
| A18792 | 26937139 | World J Gastroenterol | Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice. | 2016 | Details |
| A18856 | 26900108 | J Agric Food Chem | Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18870 | 26892709 | Exp Biol Med (Maywood) | De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles. | 2016 | Details |
| A18874 | 26890260 | PLoS One | SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. | 2016 | Details |
| A18891 | 26882978 | Biochem Biophys Res Commun | Depletion of Rab32 decreases intracellular lipid accumulation and induces lipolysis through enhancing ATGL expression in hepatocytes. | 2016 | Details |
| A18893 | 26881746 | PLoS One | Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. | 2016 | Details |
| A18910 | 26873633 | Biochim Biophys Acta | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Details |
| A18917 | 26871288 | Oncotarget | Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice. | 2016 | Details |
| A18921 | 26869449 | Biochim Biophys Acta | Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5'-UTR in a cellular model of hepatic steatosis. | 2016 | Details |
| A18929 | 26866272 | Cell Death Dis | Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. | 2016 | Details |
| A18943 | 26857750 | Sci Rep | Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. | 2016 | Details |
| A18945 | 26856717 | Dig Dis Sci | Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. | 2016 | Details |
| A18954 | 26852185 | Br J Clin Pharmacol | The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease. | 2016 | Details |
| A19017 | 26817937 | Nutr Metab Cardiovasc Dis | Serum palmitoleate acts as a lipokine in subjects at high cardiometabolic risk. | 2015 | Details |
| A19043 | 26806698 | J Pharm Pharmacol | Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice. | 2016 | Details |
| A19044 | 26806650 | Hepatology | Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice. | 2016 | Details |
| A19045 | 26805874 | Nutrients | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes. | 2016 | Details |
| A19058 | 26794005 | J Gastroenterol | Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice. | 2016 | Details |
| A19077 | 26778339 | Clin Nutr | The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis. | 2015 | Details |
| A19085 | 26773785 | Nutr Res | Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease. | 2015 | Details |
| A19086 | 26773781 | Nutr Res | Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease. | 2015 | Details |
| A19126 | 26743335 | Nat Commun | mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. | 2016 | Details |
| A19157 | 26724391 | Eur J Pharmacol | Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model. | 2015 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19214 | 26698665 | Free Radic Biol Med | Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development. | 2015 | Details |
| A19224 | 26693162 | J Diabetes Metab Disord | The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease. | 2015 | Details |
| A19235 | 26681923 | Int J Biol Sci | A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A19249 | 26674248 | BBA Clin | Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. | 2015 | Details |
| A19257 | 26670228 | Int J Mol Sci | The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice. | 2015 | Details |
| A19271 | 26663351 | Hepatology | Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice. | 2016 | Details |
| A19288 | 26648452 | J Cell Mol Med | miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21. | 2015 | Details |
| A19292 | 26645107 | J Cell Mol Med | Role of stem cells during diabetic liver injury. | 2015 | Details |
| A19310 | 26635079 | BMC Gastroenterol | Gut microbiota manipulation with prebiotics in patients with non-alcoholic fatty liver disease: a randomized controlled trial protocol. | 2015 | Details |
| A19321 | 26630290 | PLoS One | Euterpe oleracea Mart.-Derived Polyphenols Protect Mice from Diet-Induced Obesity and Fatty Liver by Regulating Hepatic Lipogenesis and Cholesterol Excretion. | 2015 | Details |
| A19323 | 26629547 | EBioMedicine | Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals. | 2015 | Details |
| A19344 | 26619117 | J Clin Invest | E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. | 2015 | Details |
| A19398 | 26592314 | Proc Nutr Soc | Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms. | 2015 | Details |
| A19412 | 26583036 | Nutr Metab (Lond) | Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content. | 2015 | Details |
| A19418 | 26580649 | Nutrients | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis. | 2015 | Details |
| A19429 | 26572131 | J Biomed Sci | Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. | 2015 | Details |
| A19437 | 26569269 | Mar Drugs | Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice. | 2015 | Details |