Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A34355 | 23665184 | J Hepatol | Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. | 2013 | Details |
| A34361 | 23640861 | Toxicol Sci | Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. | 2013 | Details |
| A34410 | 23526264 | J Clin Biochem Nutr | Effects of tocotrienol on tumor necrosis factor-α/d-galactosamine-induced steatohepatitis in rats. | 2013 | Details |
| A34685 | 22882855 | Chin Med J (Engl) | Pioglitazone ameliorates nonalcoholic steatohepatitis by down-regulating hepatic nuclear factor-kappa B and cyclooxygenases-2 expression in rats. | 2012 | Details |
| A34859 | 22411067 | Lab Invest | Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. | 2012 | Details |
| A34866 | 22392635 | Hepatology | Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase. | 2012 | Details |
| A35022 | 21933146 | Curr Pharm Des | Metabolic therapy: lessons from liver diseases. | 2011 | Details |
| A35107 | 21715691 | J Immunol | Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. | 2011 | Details |
| A35113 | 21711424 | Hepatol Res | Ursodeoxycholic acid dose-dependently improves liver injury in rats fed a methionine- and choline-deficient diet. | 2011 | Details |
| A35259 | 21276150 | Hepatol Res | Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. | 2011 | Details |
| A35338 | 21056947 | Hum Exp Toxicol | Teucrium polium reversed the MCD diet-induced liver injury in rats. | 2010 | Details |
| A35352 | 21038418 | Hepatology | Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. | 2010 | Details |
| A35430 | 20707200 | Zhongguo Zhong Yao Za Zhi | [Cigu Xiaozhi pills's influence on lipid peroxidation and TNF-alpha expression in liver tissues of rats with nonalcoholic steatohepatitis]. | 2010 | Details |
| A35520 | 20454933 | Obes Surg | Pro- and anti-inflammatory cytokines in steatosis and steatohepatitis. | 2010 | Details |
| A35552 | 20376096 | Gene Ther | PPARgamma is essential for protection against nonalcoholic steatohepatitis. | 2010 | Details |
| A35613 | 20131406 | Hepatology | Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury. | 2010 | Details |
| A35630 | 20068559 | Am J Gastroenterol | L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial. | 2010 | Details |
| A35633 | 19996485 | J Physiol Pharmacol | Adipohormones as prognostric markers in patients with nonalcoholic steatohepatitis (NASH). | 2009 | Details |
| A35650 | 20028348 | Alcohol Clin Exp Res | Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. | 2009 | Details |
| A35659 | 19998387 | Hepatology | Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. | 2010 | Details |
| A35667 | 19952284 | FASEB J | Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa. | 2009 | Details |
| A35675 | 19938191 | World J Gastroenterol | Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138. | 2009 | Details |
| A35692 | 19902480 | Hepatology | Toxicant-associated steatohepatitis in vinyl chloride workers. | 2010 | Details |
| A35710 | 19856102 | Dig Dis Sci | Highly purified eicosapentaenoic acid ethyl ester prevents development of steatosis and hepatic fibrosis in rats. | 2009 | Details |
| A35744 | 19785957 | Zhonghua Gan Zang Bing Za Zhi | [Role of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis]. | 2009 | Details |
| A35753 | 19764881 | Antioxid Redox Signal | Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice. | 2009 | Details |
| A35772 | 19721198 | Clin Calcium | [Hepato-biliary and pancreatic disease and osteodystrophy]. | 2009 | Details |
| A35781 | 19707265 | PLoS Biol | Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. | 2009 | Details |
| A35801 | 19659788 | J Dig Dis | Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non-alcoholic steatohepatitis. | 2009 | Details |
| A35805 | 19647752 | Life Sci | Synthetic triglyceride containing an arachidonic acid branch (8A8) prevents lipopolysaccharide-induced liver injury. | 2009 | Details |
| A35815 | 19631409 | Neurobiol Aging | Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide. | 2009 | Details |
| A35862 | 19544392 | Glia | Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation. | 2010 | Details |
| A35865 | 19539747 | Free Radic Biol Med | Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. | 2009 | Details |
| A35887 | 19496180 | Hepatology | Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent. | 2009 | Details |
| A35909 | 19434740 | Hepatology | Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. | 2009 | Details |
| A35968 | 19301087 | J Gastroenterol | Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? | 2009 | Details |
| A35989 | 19258673 | Acta Med Indones | Clinical picture, insulin resistance, and adipocytokines profiles of nonalcoholic steatohepatitis (NASH) patients in Indonesia. | 2009 | Details |
| A36000 | 19248189 | World J Gastroenterol | A rabbit model of pediatric nonalcoholic steatohepatitis: the role of adiponectin. | 2009 | Details |
| A36013 | 19205029 | Hepatology | Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-A(y) mice. | 2009 | Details |
| A36077 | 19053005 | Z Gastroenterol | Adalimumab could suppress the activity of non alcoholic steatohepatitis (NASH). | 2008 | Details |
| A36094 | 19013295 | Metabolism | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. | 2008 | Details |
| A36096 | 19012034 | J Gastroenterol | Adipocytokines and liver disease. | 2008 | Details |
| A36101 | 19004024 | Int J Cancer | Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. | 2009 | Details |
| A36141 | 18948497 | J Pharmacol Exp Ther | Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. | 2008 | Details |
| A36159 | 18848945 | Gastroenterology | Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. | 2008 | Details |
| A36179 | 18806095 | J Nutr | N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A36180 | 18806094 | J Nutr | Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. | 2008 | Details |
| A36189 | 18782536 | Zhong Xi Yi Jie He Xue Bao | [Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]. | 2008 | Details |
| A36192 | 18769506 | Nutr Res | The Combination of S-adenosylmethionine and Dilinoleoylphosphatidylcholine Attenuates Non-alcoholic Steatohepatitis Produced in Rats by a High-Fat Diet. | 2007 | Details |
| A36250 | 18638709 | Complement Ther Med | The effect of QuYuHuaTanTongLuo Decoction on the non-alcoholic steatohepatitis. | 2008 | Details |
| A36270 | 18571789 | Hepatology | Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A36271 | 18564121 | Am J Gastroenterol | Plasma adiponectin levels in primary biliary cirrhosis: a novel perspective for link between hypercholesterolemia and protection against atherosclerosis. | 2008 | Details |
| A36294 | 19669304 | Hepatol Int | A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH). | 2008 | Details |
| A36390 | 18310971 | Intern Med | Familial aggregation in patients with non-alcoholic steatohepatitis. | 2008 | Details |
| A36404 | 18277895 | J Clin Gastroenterol | Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. | 2008 | Details |
| A36461 | 18093684 | J Hepatol | Beneficial effects versus toxicity of medium-chain triacylglycerols in rats with NASH. | 2007 | Details |
| A36516 | 17947452 | Am J Physiol Gastrointest Liver Physiol | A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. | 2007 | Details |
| A36576 | 17710676 | Scand J Gastroenterol | Importance of cytokines, oxidative stress and expression of BCL-2 in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A36622 | 17594812 | Zhonghua Gan Zang Bing Za Zhi | [An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis]. | 2007 | Details |
| A36654 | 17518368 | Hepatology | Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. | 2007 | Details |
| A36686 | 17464987 | Hepatology | CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. | 2007 | Details |
| A36688 | 17459514 | J Hepatol | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. | 2007 | Details |
| A36698 | 17436095 | Dig Dis Sci | Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis. | 2007 | Details |
| A36699 | 17436085 | Dig Dis Sci | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36707 | 17415655 | Dig Dis Sci | Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet. | 2007 | Details |
| A36719 | 17392582 | Mediators Inflamm | Serum adipokine and ghrelin levels in nonalcoholic steatohepatitis. | 2006 | Details |
| A36810 | 17211854 | J Cell Biochem | Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. | 2007 | Details |
| A36851 | 17086867 | Hepatogastroenterology | Usefulness of serum hepatic fibrosis markers in the diagnosis of nonalcoholic steatohepatitis (NASH). | 2007 | Details |
| A36854 | 17080243 | Dig Dis Sci | The restorative effect of taurine on experimental nonalcoholic steatohepatitis. | 2006 | Details |
| A36858 | 17064471 | Zhonghua Gan Zang Bing Za Zhi | [Effects of pentoxifylline on hepatic nuclear factor-kappa B signaling pathway and insulin resistance in nonalcoholic steatohepatitis rats induced by fat-rich diet]. | 2006 | Details |
| A36925 | 16936261 | Am J Pathol | A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. | 2006 | Details |
| A36959 | 16848812 | Am J Gastroenterol | Potential role of chitotriosidase gene in nonalcoholic fatty liver disease evolution. | 2006 | Details |
| A36967 | 16814613 | Clin Gastroenterol Hepatol | Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement. | 2006 | Details |
| A36989 | 16768125 | Nihon Rinsho | [Insulin sensitizer--anti-diabetic drugs, metformin and pioglitazone that can improve insulin resistance]. | 2006 | Details |
| A36995 | 16768113 | Nihon Rinsho | [Adipokine interrelationship with the liver]. | 2006 | Details |
| A37019 | 16706830 | J Gastroenterol Hepatol | Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency. | 2006 | Details |
| A37053 | 16574099 | Eur J Pharmacol | Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2006 | Details |
| A37124 | 16420766 | Zhonghua Gan Zang Bing Za Zhi | [Upregulating expressions of hepatic lipopolysaccharide receptors in nonalcoholic steatohepatitic rats]. | 2006 | Details |
| A37143 | 16385240 | Alcohol Clin Exp Res | Clinical significance of soluble TNF receptor in Japanese patients with non-alcoholic steatohepatitis. | 2005 | Details |
| A37164 | 16357615 | Eur J Gastroenterol Hepatol | Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. | 2006 | Details |
| A37197 | 16279898 | Am J Gastroenterol | Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. | 2005 | Details |
| A37220 | 16231364 | Hepatology | Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. | 2005 | Details |
| A37248 | 16174657 | Gut | Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. | 2005 | Details |
| A37276 | 16085455 | Hepatol Res | The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, l-amino acid-defined diet. | 2005 | Details |
| A37315 | 15979653 | Life Sci | Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. | 2005 | Details |
| A37414 | 15727690 | Zhonghua Gan Zang Bing Za Zhi | [Effect of Endotoxin on the expression of peroxisome proliferator-activated receptor alpha in the development of nonalcoholic steatohepatitis in rats]. | 2005 | Details |
| A37487 | 15571584 | Am J Gastroenterol | A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. | 2004 | Details |
| A37549 | 15447754 | Am J Gastroenterol | Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. | 2004 | Details |
| A37611 | 15277442 | Diabetes Care | Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis. | 2004 | Details |
| A37639 | 15220676 | J Clin Gastroenterol | Probiotics: a potential target for the prevention and treatment of steatohepatitis. | 2004 | Details |
| A37708 | 15066643 | Eur J Intern Med | Non-alcoholic steatohepatitis: review of a growing medical problem. | 2004 | Details |
| A37721 | 15044174 | Am J Physiol Gastrointest Liver Physiol | Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. | 2004 | Details |
| A37737 | 14985228 | Am J Clin Nutr | Model of nonalcoholic steatohepatitis. | 2004 | Details |
| A37764 | 14720457 | Curr Gastroenterol Rep | Advances in alcoholic liver disease. | 2004 | Details |
| A37836 | 14512887 | Hepatology | Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. | 2003 | Details |
| A37879 | 12883485 | Hepatology | Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. | 2003 | Details |
| A37974 | 12648396 | Zhonghua Gan Zang Bing Za Zhi | [Change of serum endotoxin level in the progress of nonalcoholic steatohepatitis in rats]. | 2003 | Details |
| A38046 | 12409257 | Mol Ther | Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. | 2002 | Details |
| A38085 | 12192203 | J Clin Gastroenterol | Management of nonalcoholic steatohepatitis: an analytic review. | 2002 | Details |
| A38270 | 11732005 | Hepatology | Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. | 2001 | Details |