Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A28906 | 34843960 | Pharmacol Res | Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases. | 2021 | Details |
| A28945 | 34789265 | J Nanobiotechnology | Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis. | 2021 | Details |
| A29069 | 34624527 | Cell Mol Gastroenterol Hepatol | Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. | 2021 | Details |
| A29148 | 34506952 | Cell Mol Gastroenterol Hepatol | Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway. | 2021 | Details |
| A29167 | 34482560 | Hepatology | Melanoma differentiation-Associated gene 5 protects against NASH in mice. | 2021 | Details |
| A29175 | 34470535 | Hum Exp Toxicol | Effect of curcumin on the non-alcoholic steatohepatitis via inhibiting the M1 polarization of macrophages. | 2021 | Details |
| A29183 | 34441565 | Foods | White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice. | 2021 | Details |
| A29247 | 34360581 | Int J Mol Sci | The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia. | 2021 | Details |
| A29345 | 34221233 | Oxid Med Cell Longev | Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway. | 2021 | Details |
| A29609 | 33802238 | Cancers (Basel) | Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. | 2021 | Details |
| A29623 | 33787460 | J Recept Signal Transduct Res | SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH). | 2021 | Details |
| A29736 | 33604255 | J Clin Transl Hepatol | New Drugs on the Block-Emerging Treatments for Nonalcoholic Steatohepatitis. | 2020 | Details |
| A29855 | 33390537 | Biol Pharm Bull | Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products. | 2021 | Details |
| A29858 | 33383845 | Antioxidants (Basel) | Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH). | 2020 | Details |
| A29876 | 33354276 | Oxid Med Cell Longev | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | 2020 | Details |
| A29903 | 33296631 | Med Sci (Paris) | [Caspase inhibition: From cellular biology and thanatology to potential clinical agents]. | 2020 | Details |
| A29976 | 33178326 | Evid Based Complement Alternat Med | Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. | 2020 | Details |
| A30027 | 33102487 | Front Cell Dev Biol | Distinct Factors Secreted by Adipose Stromal Cells Protect the Endothelium From Barrier Dysfunction and Apoptosis. | 2020 | Details |
| A30098 | 32990984 | J Bone Miner Res | A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. | 2020 | Details |
| A30146 | 32903542 | Front Cell Dev Biol | Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner. | 2020 | Details |
| A30204 | 32821335 | World J Hepatol | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. | 2020 | Details |
| A30225 | 32787548 | Cell Cycle | NaSH increases SIRT1 activity and autophagy flux through sulfhydration to protect SH-SY5Y cells induced by MPP~. | 2020 | Details |
| A30436 | 32448510 | Biochem Biophys Res Commun | Involvement of activation of PLIN5-Sirt1 axis in protective effect of glycycoumarin on hepatic lipotoxicity. | 2020 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A30491 | 32347601 | Cell Prolif | Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration. | 2020 | Details |
| A30606 | 32121273 | Int J Mol Sci | Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis-A Novel Form of Non-Apoptotic Cell Death? | 2020 | Details |
| A30670 | 32021639 | Nutr Metab (Lond) | Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. | 2020 | Details |
| A30684 | 31996485 | JCI Insight | ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. | 2020 | Details |
| A30790 | 31777145 | Int J Exp Pathol | The effects of intravitreal H2 S application on apoptosis in the retina and cornea in experimental glaucoma model. | 2019 | Details |
| A30836 | 31703613 | BMC Mol Biol | PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism. | 2019 | Details |
| A30854 | 31667206 | Regen Ther | Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions. | 2019 | Details |
| A30889 | 31612792 | J Biomol Struct Dyn | Discovery of potent apoptosis signal-regulating kinase 1 inhibitors via integrated computational strategy and biological evaluation. | 2019 | Details |
| A31047 | 31321239 | Biomed Res Int | Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. | 2019 | Details |
| A31102 | 31222801 | Hepatology | Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | 2019 | Details |
| A31241 | 30972180 | Am J Transl Res | Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. | 2019 | Details |
| A31337 | 30766962 | Hepatol Commun | An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A31465 | 30521368 | Can J Physiol Pharmacol | Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis. | 2018 | Details |
| A31544 | 30315846 | Cancer Lett | Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. | 2018 | Details |
| A31583 | 30248539 | Biomed Pharmacother | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. | 2018 | Details |
| A31661 | 30084831 | J Lipid Res | Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. | 2018 | Details |
| A31754 | 29913280 | Clin Gastroenterol Hepatol | Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo. | 2018 | Details |
| A31769 | 29897812 | FASEB J | Inflammasome activation in Kupffer cells confers a protective response in nonalcoholic steatohepatitis through pigment epithelium-derived factor expression. | 2018 | Details |
| A31910 | 29571256 | Biomed Pharmacother | Hydrogen sulfide upregulated lncRNA CasC7 to reduce neuronal cell apoptosis in spinal cord ischemia-reperfusion injury rat. | 2018 | Details |
| A31920 | 29552860 | Zhongguo Zhong Yao Za Zhi | [Protective effects of total saponins of Panax japonicas on HepG2 cell apoptosis induced with palmitic acid]. | 2018 | Details |
| A31979 | 29404484 | Hepatol Commun | The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. | 2017 | Details |
| A32016 | 29316085 | Hepatol Res | Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis. | 2018 | Details |
| A32082 | 29234397 | Evid Based Complement Alternat Med | Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. | 2017 | Details |
| A32089 | 29215307 | Biotech Histochem | Effects of intravitreous sodium hydrosulfide on intraocular pressure and retinopathy in ocular hypertensive rats. | 2017 | Details |
| A32137 | 29124251 | Hepatol Commun | TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity. | 2017 | Details |
| A32197 | 28981243 | Rev Med Brux | [Treatments of non-alcoholic steatohepatitis]. | 2019 | Details |
| A32226 | 28933629 | Autophagy | Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. | 2017 | Details |
| A32421 | 28487545 | Nat Rev Gastroenterol Hepatol | Mechanisms of hepatic stellate cell activation. | 2017 | Details |
| A32509 | 28250026 | J Lipid Res | FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis. | 2017 | Details |
| A32548 | 28133511 | Toxicol Res | Evaluating the Influence of Side Stream Cigarette Smoke at an Early Stage of Non-Alcoholic Steatohepatitis Progression in Mice. | 2017 | Details |
| A32677 | 27740615 | Cancer Gene Ther | Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer. | 2016 | Details |
| A32748 | 27605885 | World J Gastroenterol | c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning. | 2016 | Details |
| A32803 | 27453055 | Exp Mol Pathol | M1-/M2-macrophage polarization in pseudolobules consisting of adipohilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis. | 2016 | Details |
| A32879 | 27182456 | J Clin Cell Immunol | Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. | 2016 | Details |
| A32934 | 27062266 | Hepatol Res | L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice. | 2016 | Details |
| A32958 | 26990427 | PLoS One | The Impact of Liver Cell Injury on Health-Related Quality of Life in Patients with Chronic Liver Disease. | 2016 | Details |
| A33009 | 26869935 | Front Physiol | The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. | 2016 | Details |
| A33165 | 26566303 | J Clin Biochem Nutr | Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose. | 2015 | Details |
| A33370 | 26111628 | Mol Neurobiol | Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats. | 2015 | Details |
| A33402 | 26056963 | Int J Cardiol | Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide. | 2015 | Details |
| A33404 | 26054298 | Purinergic Signal | Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells. | 2015 | Details |
| A33442 | 25978364 | PLoS One | Liver injury and fibrosis induced by dietary challenge in the Ossabaw miniature Swine. | 2015 | Details |
| A33571 | 25682949 | Phytother Res | Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. | 2015 | Details |
| A33583 | 25654228 | Int J Mol Sci | Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes. | 2015 | Details |
| A33635 | 25548285 | J Biol Chem | Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. | 2014 | Details |
| A33670 | 25461268 | Nitric Oxide | Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes. | 2014 | Details |
| A33676 | 25448926 | Gastroenterology | Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. | 2014 | Details |
| A33711 | 25343994 | BMC Res Notes | Cellular responses to Sindbis virus infection of neural progenitors derived from human embryonic stem cells. | 2014 | Details |
| A33781 | 25168747 | Bioorg Med Chem Lett | NaSH in the construction of thiophene ring fused with N-heterocycles: a rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis. | 2014 | Details |
| A33803 | 25123818 | Int J Cancer | TRAIL expression levels in human hepatocellular carcinoma have implications for tumor growth, recurrence and survival. | 2014 | Details |
| A33835 | 25046161 | Gastroenterology | Cell death and cell death responses in liver disease: mechanisms and clinical relevance. | 2014 | Details |
| A33839 | 25038800 | BMC Complement Altern Med | Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells. | 2014 | Details |
| A33915 | 24885871 | Lipids Health Dis | Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. | 2014 | Details |
| A34043 | 24570955 | Hepatobiliary Surg Nutr | Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. | 2013 | Details |
| A34044 | 24570954 | Hepatobiliary Surg Nutr | Eat more carrots? Dampening cell death in ethanol-induced liver fibrosis by β-carotene. | 2013 | Details |
| A34094 | 24421392 | Mol Cell Biol | c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. | 2014 | Details |
| A34199 | 24145238 | Lab Invest | A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance. | 2013 | Details |
| A34237 | 23996730 | Hepatology | Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. | 2013 | Details |
| A34238 | 23995653 | Biol Pharm Bull | Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. | 2013 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A34278 | 23877747 | Nutr Diabetes | Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury. | 2013 | Details |
| A34296 | 23828575 | Cell Death Dis | Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. | 2013 | Details |
| A34355 | 23665184 | J Hepatol | Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. | 2013 | Details |
| A34486 | 23339067 | Hepatology | Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents. | 2013 | Details |
| A34499 | 23322710 | Hepatology | Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. | 2013 | Details |
| A34699 | 22846855 | Semin Oncol | Some new approaches to the management of hepatocellular carcinoma. | 2012 | Details |
| A34842 | 22450891 | Curr Opin Gastroenterol | Keratins: markers and modulators of liver disease. | 2012 | Details |
| A34862 | 22404726 | J Viral Hepat | Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis. | 2011 | Details |
| A34866 | 22392635 | Hepatology | Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase. | 2012 | Details |
| A35003 | 22006541 | Hepatology | A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. | 2011 | Details |
| A35005 | 21993925 | Hepatology | Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. | 2011 | Details |
| A35022 | 21933146 | Curr Pharm Des | Metabolic therapy: lessons from liver diseases. | 2011 | Details |
| A35052 | 21865331 | Am J Clin Nutr | Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis. | 2011 | Details |
| A35067 | 21818687 | Hepatol Int | Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. | 2011 | Details |
| A35088 | 21769076 | Minerva Gastroenterol Dietol | MicroRNA and hepatocellular carcinoma: biology and prognostic significance. | 2011 | Details |
| A35214 | 21425308 | Hepatology | Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. | 2011 | Details |