Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21524 | 25254002 | Metabolomics | Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer. | 2014 | Details |
| A21551 | 25234945 | J Hepatol | Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. | 2014 | Details |
| A21556 | 25232450 | World J Hepatol | Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease. | 2014 | Details |
| A21576 | 25216251 | PLoS One | IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. | 2014 | Details |
| A21580 | 25214402 | Am J Physiol Gastrointest Liver Physiol | Vitamin D deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model. | 2014 | Details |
| A21590 | 25203315 | Hepatology | ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. | 2015 | Details |
| A21611 | 25187371 | Diabetes | PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα. | 2014 | Details |
| A21617 | 25183508 | Acta Physiol Hung | Naltrexone attenuates endoplasmic reticulum stress induced hepatic injury in mice. | 2014 | Details |
| A21620 | 25182422 | Arch Toxicol | Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. | 2014 | Details |
| A21643 | 25157160 | Proc Natl Acad Sci U S A | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway. | 2014 | Details |
| A21645 | 25156247 | Liver Int | Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. | 2014 | Details |
| A21648 | 25154569 | J Nutr Biochem | Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats. | 2014 | Details |
| A21668 | 25136608 | Biomed Res Int | Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway. | 2014 | Details |
| A21695 | 25112833 | J Endocrinol | Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. | 2014 | Details |
| A21697 | 25111690 | Lab Invest | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. | 2014 | Details |
| A21706 | 25105012 | Cell Biosci | Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. | 2014 | Details |
| A21709 | 25102981 | Dig Dis Sci | Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A21715 | 25099546 | Am J Clin Nutr | Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. | 2014 | Details |
| A21753 | 25071327 | World J Gastroenterol | Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. | 2014 | Details |
| A21767 | 25060692 | Metabolism | Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells. | 2014 | Details |
| A21772 | 25057104 | Nutrients | Pinus densiflora Sieb. et Zucc. alleviates lipogenesis and oxidative stress during oleic acid-induced steatosis in HepG2 cells. | 2014 | Details |
| A21785 | 25045618 | Curr Hepatol Rep | Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. | 2014 | Details |
| A21813 | 25028495 | Proc Natl Acad Sci U S A | Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. | 2014 | Details |
| A21815 | 25026599 | Biochem Pharmacol | Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. | 2014 | Details |
| A21833 | 25016220 | J Hepatol | Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity. | 2014 | Details |
| A21842 | 25008241 | Mol Cell Endocrinol | Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis. | 2014 | Details |
| A21846 | 25003952 | J Hepatol | Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo. | 2014 | Details |
| A21859 | 24993831 | J Biol Chem | Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype. | 2014 | Details |
| A21877 | 24985011 | Nutrition | Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. | 2013 | Details |
| A21880 | 24983336 | Med Sci Sports Exerc | Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training. | 2015 | Details |
| A21891 | 24976401 | Biochem Biophys Res Commun | NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease. | 2014 | Details |
| A21920 | 24966582 | World J Gastroenterol | Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen. | 2014 | Details |
| A21930 | 24958099 | Mol Cell Biol | Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. | 2014 | Details |
| A21933 | 24955981 | Biochem Pharmacol | LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver. | 2014 | Details |
| A21935 | 24953607 | Life Sci | Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice. | 2014 | Details |
| A21959 | 24932972 | Br J Nutr | Long-term intake of soyabean phytosterols lowers serum TAG and NEFA concentrations, increases bile acid synthesis and protects against fatty liver development in dyslipidaemic hamsters. | 2014 | Details |
| A21966 | 24927063 | Mol Med Rep | Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non‑alcoholic fatty liver disease via adenosine monophosphate‑activated protein kinase pathway activation. | 2014 | Details |
| A21968 | 24926685 | PLoS One | Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect. | 2014 | Details |
| A21991 | 24905748 | Nutrients | Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats. | 2014 | Details |
| A22003 | 24899308 | Nature | The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. | 2014 | Details |
| A22043 | 24854865 | FEBS J | Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB. | 2014 | Details |
| A22069 | 24842304 | J Hepatol | Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia. | 2014 | Details |
| A22070 | 24841999 | Food Funct | Persimmon tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in high-fat diet rats. | 2014 | Details |
| A22104 | 24818764 | Gastroenterology | No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. | 2014 | Details |
| A22111 | 24814684 | Metabolism | De novo lipogenesis in health and disease. | 2014 | Details |
| A22115 | 24806753 | Hepatology | FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. | 2014 | Details |
| A22123 | 24799987 | World J Hepatol | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease. | 2014 | Details |
| A22278 | 24695736 | J Biol Chem | Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. | 2014 | Details |
| A22282 | 24692138 | Compr Physiol | Energy metabolism in the liver. | 2014 | Details |
| A22307 | 24677249 | Hepatology | Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. | 2014 | Details |
| A22322 | 24665739 | Sheng Li Ke Xue Jin Zhan | [Progress in research of the mechanisms related with the hepatic steatosis in the nonalcoholic fatty liver disease]. | 2013 | Details |
| A22370 | 24633463 | Arch Pharm Res | Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase. | 2014 | Details |
| A22388 | 24627299 | Lipids | Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice. | 2014 | Details |
| A22427 | 24587652 | World J Gastroenterol | Modulation of hepatic steatosis by dietary fatty acids. | 2014 | Details |
| A22471 | 24534255 | Toxicol Appl Pharmacol | PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells. | 2014 | Details |
| A22490 | 24519932 | J Biol Chem | Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. | 2014 | Details |
| A22507 | 24506864 | Cell Metab | The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. | 2014 | Details |
| A22641 | 24389359 | J Mol Endocrinol | TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. | 2014 | Details |
| A22664 | 24376752 | PLoS One | COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. | 2013 | Details |
| A22684 | 26015978 | Mol Ther Methods Clin Dev | AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease. | 2014 | Details |
| A22708 | 24365744 | Transl Res | Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease. | 2013 | Details |
| A22714 | 24362075 | J Hepatol | Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation. | 2013 | Details |
| A22746 | 24335764 | Int J Obes (Lond) | Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. | 2013 | Details |
| A22750 | 24333182 | J Hepatol | Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice. | 2013 | Details |
| A22757 | 24327268 | Hepatology | Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ. | 2014 | Details |
| A22759 | 24326426 | Am J Physiol Endocrinol Metab | Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats. | 2013 | Details |
| A22776 | 24316260 | Gastroenterology | Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. | 2013 | Details |
| A22783 | 24307947 | J Lipids | Grape seed proanthocyanidin rescues rats from steatosis: a comparative and combination study with metformin. | 2013 | Details |
| A22792 | 24302567 | Mol Nutr Food Res | Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds. | 2013 | Details |
| A22799 | 24295779 | Biochim Biophys Acta | Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice. | 2014 | Details |
| A22802 | 24292949 | Genes Nutr | Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats. | 2013 | Details |
| A22833 | 24275089 | Food Chem Toxicol | Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. | 2013 | Details |
| A22894 | 24239806 | Toxicol Lett | Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. | 2013 | Details |
| A22933 | 24196354 | Int J Mol Sci | Hepatic adverse effects of fructose consumption independent of overweight/obesity. | 2013 | Details |
| A22937 | 24192698 | Pediatr Res | Developmental origins of nonalcoholic fatty liver disease. | 2013 | Details |
| A22949 | 24185692 | Nat Med | Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. | 2013 | Details |
| A22965 | 24167955 | Arch Latinoam Nutr | Prevention of liver steatosis through fish oil supplementation: correlation of oxidative stress with insulin resistance and liver fatty acid content. | 2013 | Details |
| A22979 | 24142602 | Eur Rev Med Pharmacol Sci | Curcumin decreases oleic acid-induced lipid accumulation via AMPK phosphorylation in hepatocarcinoma cells. | 2013 | Details |
| A22989 | 24133660 | Clin Mol Hepatol | Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. | 2013 | Details |
| A23002 | 24121055 | Toxicol Appl Pharmacol | Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles. | 2013 | Details |
| A23031 | 24097666 | Toxicol Sci | The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. | 2013 | Details |
| A23096 | 24042997 | Int J Mol Med | The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed rats. | 2013 | Details |
| A23105 | 24038130 | Hepatology | Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis. | 2014 | Details |
| A23106 | 24038081 | Hepatology | All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. | 2014 | Details |
| A23119 | 24027117 | J Sci Food Agric | The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase. | 2013 | Details |
| A23170 | 23985808 | Am J Clin Nutr | Impact of sterol regulatory element-binding factor-1c polymorphism on incidence of nonalcoholic fatty liver disease and on the severity of liver disease and of glucose and lipid dysmetabolism. | 2013 | Details |
| A23178 | 23982157 | Am J Physiol Endocrinol Metab | Intracellular lipid content is a key intrinsic determinant for hepatocyte viability and metabolic and inflammatory states in mice. | 2013 | Details |
| A23205 | 23960084 | Mol Endocrinol | Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD. | 2013 | Details |
| A23269 | 23913732 | Obesity (Silver Spring) | Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. | 2013 | Details |
| A23273 | 23909258 | Vnitr Lek | [Effects of GLP-1 (glucagon-like peptide 1) on liver]. | 2013 | Details |
| A23311 | 23855304 | J Gastroenterol Hepatol | Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease. | 2013 | Details |
| A23385 | 23828743 | Saudi J Gastroenterol | The role of endocannabinoids system in fatty liver disease and therapeutic potentials. | 2014 | Details |
| A23413 | 23804416 | Obesity (Silver Spring) | Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. | 2013 | Details |
| A23426 | 23792031 | J Hepatol | The role of hepassocin in the development of non-alcoholic fatty liver disease. | 2013 | Details |
| A23427 | 23793849 | Curr Hypertens Rep | Fructose-containing sugars, blood pressure, and cardiometabolic risk: a critical review. | 2013 | Details |
| A23430 | 23792151 | Biochimie | Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences. | 2013 | Details |
| A23431 | 23791610 | Eur J Pharmacol | Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Pparα). | 2013 | Details |
| A23487 | 23737763 | Gastroenterol Res Pract | Time course of the development of nonalcoholic Fatty liver disease in the Otsuka long-evans Tokushima Fatty rat. | 2013 | Details |
| A23519 | 23715726 | Am J Physiol Endocrinol Metab | Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet. | 2013 | Details |
| A23535 | 23702383 | Metabolism | Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway. | 2013 | Details |