Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A49577 | 35708630 | J Med Food | Nil-Surin Rice Bran Hydrolysates Improve Lipid Metabolism and Hepatic Steatosis by Regulating Secretion of Adipokines and Expression of Lipid-Metabolism Genes. | 2022 | Details |
| A49591 | 35700738 | Cell Metab | MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. | 2022 | Details |
| A49628 | 35685876 | Front Nutr | Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3. | 2022 | Details |
| A49641 | 35682942 | Int J Mol Sci | Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice. | 2022 | Details |
| A49650 | 35678936 | Plant Foods Hum Nutr | Hypolipidemic Effects of Soy Protein and Isoflavones in the Prevention of Non-Alcoholic Fatty Liver Disease- A Review. | 2022 | Details |
| A49664 | 35677306 | Front Bioeng Biotechnol | AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and Epigenetic Changes in Mice With NAFLD Induced by HFD. | 2022 | Details |
| A49669 | 35675800 | Cell Metab | Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia. | 2022 | Details |
| A49720 | 35657825 | PLoS One | Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high-fat diet in the mouse model. | 2022 | Details |
| A49784 | 35639028 | FASEB J | A new preclinical model of western diet-induced progression of non-alcoholic steatohepatitis to hepatocellular carcinoma. | 2022 | Details |
| A49786 | 35637957 | Int J Biol Sci | The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1. | 2022 | Details |
| A49798 | 35634707 | Gut Microbes | Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis. | 2022 | Details |
| A49804 | 35631404 | Pharmaceuticals (Basel) | Food-Derived β-Carboline Alkaloids Ameliorate Lipid Droplet Accumulation in Human Hepatocytes. | 2022 | Details |
| A49805 | 35631319 | Nutrients | Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial. | 2022 | Details |
| A49810 | 35630058 | Medicina (Kaunas) | Chronic Inflammation-A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue. | 2022 | Details |
| A49839 | 35624762 | Antioxidants (Basel) | Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice. | 2022 | Details |
| A49882 | 35609858 | J Nutr Biochem | Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD. | 2022 | Details |
| A49905 | 35602098 | Oxid Med Cell Longev | A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases. | 2022 | Details |
| A49922 | 35594708 | Biomed Pharmacother | Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress. | 2022 | Details |
| A49931 | 35590219 | Med (N Y) | Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial. | 2021 | Details |
| A49944 | 35586049 | Front Pharmacol | Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice. | 2022 | Details |
| A50018 | 35563076 | Int J Mol Sci | Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice. | 2022 | Details |
| A50069 | 35536225 | J Agric Food Chem | Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation. | 2022 | Details |
| A50083 | 35533489 | Biochem Biophys Res Commun | DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation. | 2022 | Details |
| A50116 | 35517790 | Front Pharmacol | FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism. | 2022 | Details |
| A50130 | 35509327 | Autophagy Rep | Scramblases as Regulators of Autophagy and Lipid Homeostasis: Implications for NAFLD. | 2022 | Details |
| A50177 | 35489641 | Ann Hepatol | Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease. | 2022 | Details |
| A50180 | 35487948 | Sci Rep | Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet. | 2022 | Details |
| A50193 | 35483638 | J Control Release | Celastrol-loaded lactosylated albumin nanoparticles attenuate hepatic steatosis in non-alcoholic fatty liver disease. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50275 | 35447541 | Biomed Pharmacother | Obeticholic acid inhibits hepatic fatty acid uptake independent of FXR in mouse. | 2022 | Details |
| A50277 | 35447114 | J Biol Chem | Leukemia inhibitory factor protects against liver steatosis in nonalcoholic fatty liver disease patients and obese mice. | 2022 | Details |
| A50290 | 35442594 | Int J Med Mushrooms | Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice. | 2022 | Details |
| A50306 | 35437549 | Food Funct | L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats. | 2022 | Details |
| A50353 | 35420934 | Science | Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. | 2022 | Details |
| A50354 | 35420931 | Science | Complex regulation of fatty liver disease. | 2022 | Details |
| A50360 | 35418153 | Diabetol Metab Syndr | Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet. | 2022 | Details |
| A50361 | 35417923 | Hum Mol Genet | Role of non-coding RNAs on liver metabolism and NAFLD pathogenesis. | 2022 | Details |
| A50394 | 35406631 | Cells | Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. | 2022 | Details |
| A50418 | 35398611 | Biochem Biophys Res Commun | Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling. | 2022 | Details |
| A50425 | 35396857 | J Food Biochem | Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. | 2022 | Details |
| A50432 | 35394671 | FASEB J | Hepatic lipid accumulation induced by a high-fat diet is regulated by Nrf2 through multiple pathways. | 2022 | Details |
| A50442 | 35390440 | Food Chem Toxicol | Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice. | 2022 | Details |
| A50464 | 35380992 | J Clin Invest | Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. | 2022 | Details |
| A50466 | 35379885 | Sci Rep | Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway. | 2022 | Details |
| A50497 | 35364708 | Nat Prod Bioprospect | Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet. | 2022 | Details |
| A50511 | 35358477 | Biochem Pharmacol | Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress. | 2022 | Details |
| A50512 | 35357518 | Naunyn Schmiedebergs Arch Pharmacol | Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor signaling pathways. | 2022 | Details |
| A50524 | 35354614 | BMJ Open | Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study. | 2022 | Details |
| A50532 | 35351574 | J Ethnopharmacol | Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways. | 2022 | Details |
| A50536 | 35349482 | J Clin Invest | Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model. | 2022 | Details |
| A50557 | 35341816 | Environ Pollut | Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice. | 2022 | Details |
| A50576 | 35334784 | Nutrients | Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review. | 2022 | Details |
| A50581 | 35333579 | Sci Adv | Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. | 2022 | Details |
| A50590 | 35331900 | J Nutr Biochem | Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease. | 2022 | Details |
| A50595 | 35329997 | J Clin Med | Heparanase Inhibition Prevents Liver Steatosis in E0 Mice. | 2022 | Details |
| A50599 | 35328587 | Int J Mol Sci | Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models. | 2022 | Details |
| A50600 | 35328564 | Int J Mol Sci | A Novel Sprague-Dawley Rat Model Presents Improved NASH/NAFLD Symptoms with PEG Coated Vitexin Liposomes. | 2022 | Details |
| A50612 | 35326122 | Antioxidants (Basel) | Lingonberry Improves Hepatic Lipid Metabolism by Targeting Notch1 Signaling. | 2022 | Details |
| A50622 | 35323681 | Metabolites | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH. | 2022 | Details |
| A50653 | 35313531 | Metabol Open | Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents. | 2022 | Details |
| A50671 | 35307486 | Cancer Lett | Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma. | 2022 | Details |
| A50678 | 35305493 | Biochem Biophys Res Commun | Transcriptomic analysis reveals a novel regulatory factor of ECHDC1 involved in lipid metabolism of non-alcoholic fatty liver disease. | 2022 | Details |
| A50681 | 35304272 | J Ethnopharmacol | Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. | 2022 | Details |
| A50713 | 35290413 | PLoS One | Abelmoschus esculentus subfractions ameliorate hepatic lipogenesis and lipid uptake via regulating dipeptidyl peptidase-4-With improving insulin resistance. | 2022 | Details |
| A50750 | 35278405 | Eur J Pharmacol | Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis. | 2022 | Details |
| A50792 | 35264693 | Sci Rep | Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro. | 2022 | Details |
| A50810 | 35218717 | Eur J Pharmacol | HA-20 prevents hepatocyte steatosis in metabolic-associated fatty liver disease via regulating Ca2+ relative signalling pathways. | 2022 | Details |
| A50890 | 34271222 | Mol Metab | Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease. | 2021 | Details |
| A51056 | 19596475 | J Hepatol | Cigarette smoke exposure: a novel cofactor of NAFLD progression? | 2009 | Details |
| A51115 | 35678694 | Curr Issues Mol Biol | Lycopus lucidus Turcz Water Extract Ameliorates the Metabolic Disorder by Up-Regulated Major Urinary Protein Expression in High-Fat Diet-Induced Obesity. | 2022 | Details |
| A51134 | 35559233 | Front Pharmacol | Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network Pharmacology. | 2022 | Details |
| A51157 | 35447117 | J Biol Chem | Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis. | 2022 | Details |
| A51161 | 35427802 | Clin Res Hepatol Gastroenterol | The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice. | 2022 | Details |
| A51177 | 35355504 | Neuropsychiatr Dis Treat | Early Lipid Metabolic Effects of the Anti-Psychotic Drug Olanzapine on Weight Gain and the Associated Gene Expression. | 2022 | Details |
| A51251 | 35280676 | Int J Biol Sci | Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. | 2022 | Details |
| A51289 | 240742 | Fed Proc | Differences in hepatic and metabolic changes after acute and chronic alcohol consumption. | 1975 | Details |
| A51306 | 35735253 | Hepatol Commun | Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis. | 2022 | Details |
| A51412 | 35709720 | Semin Liver Dis | Non-Alcoholic Steatohepatitis Drug Development Pipeline: An Update. | 2022 | Details |
| A51507 | 35743314 | Int J Mol Sci | Adaptation of Oxidative Phosphorylation Machinery Compensates for Hepatic Lipotoxicity in Early Stages of MAFLD. | 2022 | Details |
| A51542 | 35409324 | Int J Mol Sci | Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice. | 2022 | Details |
| A51594 | 34695608 | Mol Metab | Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. | 2021 | Details |
| A51605 | 35723871 | FASEB J | Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice. | 2022 | Details |
| A51626 | 35495929 | Front Nutr | Astaxanthin From Haematococcus pluvialis Prevents High-Fat Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver Axis Modulating Properties. | 2022 | Details |
| A51630 | 35483558 | Biochim Biophys Acta Mol Cell Biol Lipids | The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells. | 2022 | Details |
| A51637 | 35453816 | Biology (Basel) | High-Fructose Diet Increases Renal ChREBPβ Expression, Leading to Intrarenal Fat Accumulation in a Rat Model with Metabolic Syndrome. | 2022 | Details |
| A51669 | 35070060 | World J Diabetes | Gut microbiota-derived metabolites are novel targets for improving insulin resistance. | 2022 | Details |
| A51692 | 34896612 | Int J Biochem Cell Biol | Odd chain fatty acid metabolism in mice after a high fat diet. | 2021 | Details |
| A51702 | 34801412 | Trends Mol Med | Clock-modulated checkpoints in time-restricted eating. | 2021 | Details |
| A51713 | 34687058 | J Inherit Metab Dis | Fructose-1,6-bisphosphatase deficiency causes fatty liver disease and requires long-term hepatic follow-up. | 2021 | Details |
| A51785 | 34079069 | Int J Obes (Lond) | Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice. | 2021 | Details |
| A51841 | 33785341 | Life Sci | Vascular endothelial growth factor B exerts lipid-lowering effect by activating AMPK via VEGFR1. | 2021 | Details |
| A51859 | 33631318 | Cell Signal | Sphingosine 1-phosphate metabolism and insulin signaling. | 2021 | Details |
| A51888 | 33449293 | Endocrine | Glucocorticoid signaling and lipid metabolism disturbances in the liver of rats treated with 5α-dihydrotestosterone in an animal model of polycystic ovary syndrome. | 2021 | Details |
| A51902 | 33340617 | Cancer Lett | ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway. | 2020 | Details |
| A51935 | 33083279 | Liver Cancer | Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. | 2020 | Details |
| A51942 | 33038868 | Phytomedicine | Suppression of up-regulated LXRα by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism. | 2020 | Details |
| A52005 | 32432943 | Autophagy | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | 2020 | Details |
| A52034 | 32079675 | J Biol Chem | Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export. | 2020 | Details |
| A52038 | 32007662 | J Nutr Biochem | Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways. | 2020 | Details |
| A52045 | 31925559 | Metabolomics | Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver. | 2020 | Details |