Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A13316 | 30036051 | J Agric Food Chem | Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. | 2018 | Details |
| A13333 | 30026784 | Nutr Metab (Lond) | Changes in lysophospholipids and liver status after weight loss: the RESMENA study. | 2018 | Details |
| A13334 | 30026731 | Front Endocrinol (Lausanne) | Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. | 2018 | Details |
| A13342 | 30024933 | PLoS One | miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. | 2018 | Details |
| A13356 | 30016988 | Lipids Health Dis | Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress. | 2018 | Details |
| A13361 | 30015906 | Mol Med Rep | Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress. | 2018 | Details |
| A13374 | 30012333 | Gastroenterology | Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. | 2018 | Details |
| A13380 | 30009716 | Endocr Metab Immune Disord Drug Targets | Overexpression of Hepassocin in Diabetic Patients with Nonalcoholic Fatty Liver Disease May Facilitate Increased Hepatic Lipid Accumulation. | 2019 | Details |
| A13383 | 30008738 | PPAR Res | Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice. | 2018 | Details |
| A13388 | 30006135 | Arch Biochem Biophys | Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. | 2018 | Details |
| A13400 | 29996339 | Zhonghua Gan Zang Bing Za Zhi | [Effect of lipid-induced macrophage M1/M2 polarization on lipid metabolism in hepatocytes]. | 2018 | Details |
| A13411 | 29991872 | World J Gastroenterol | Apoptosis and non-alcoholic fatty liver diseases. | 2018 | Details |
| A13412 | 29990865 | Biomed Pharmacother | Tangganjian decoction ameliorates type 2 diabetes mellitus and nonalcoholic fatty liver disease in rats by activating the IRS/PI3K/AKT signaling pathway. | 2018 | Details |
| A13420 | 29987933 | J Agric Food Chem | Pectin Alleviates High Fat (Lard) Diet-Induced Nonalcoholic Fatty Liver Disease in Mice: Possible Role of Short-Chain Fatty Acids and Gut Microbiota Regulated by Pectin. | 2018 | Details |
| A13437 | 29974410 | Hepatol Int | Non-alcoholic hepatic steatosis attenuates hepatitis B virus replication in an HBV-immunocompetent mouse model. | 2018 | Details |
| A13441 | 29972240 | J Physiol | Maternal obesity has sex-dependent effects on insulin, glucose and lipid metabolism and the liver transcriptome in young adult rat offspring. | 2018 | Details |
| A13443 | 29971527 | Diabetologia | Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study. | 2018 | Details |
| A13450 | 29967579 | Front Aging Neurosci | Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease. | 2018 | Details |
| A13464 | 29959418 | Lab Invest | Characterization of a murine nonalcoholic steatohepatitis model induced by high fat high calorie diet plus fructose and glucose in drinking water. | 2018 | Details |
| A13466 | 29958960 | J Ethnopharmacol | The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice. | 2018 | Details |
| A13468 | 29956790 | Mol Med Rep | Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. | 2018 | Details |
| A13472 | 29956211 | Adv Exp Med Biol | Autophagy, NAFLD and NAFLD-Related HCC. | 2018 | Details |
| A13474 | 29956209 | Adv Exp Med Biol | The Influence of Gut Microbial Metabolism on the Development and Progression of Non-alcoholic Fatty Liver Disease. | 2018 | Details |
| A13479 | 29956204 | Adv Exp Med Biol | Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. | 2018 | Details |
| A13486 | 29954129 | Int J Mol Sci | Insights into the Role of PPARβ/δ in NAFLD. | 2018 | Details |
| A13488 | 29953011 | Medicine (Baltimore) | Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China. | 2018 | Details |
| A13490 | 29951838 | Biochem Genet | Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions. | 2018 | Details |
| A13493 | 29950116 | Expert Opin Investig Drugs | MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis. | 2018 | Details |
| A13497 | 29947894 | Arch Toxicol | Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126. | 2018 | Details |
| A13500 | 29947103 | Eur J Clin Invest | Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease. | 2018 | Details |
| A13504 | 29945982 | J Endocrinol | INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function. | 2018 | Details |
| A13512 | 29940269 | J Hepatol | Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. | 2018 | Details |
| A13515 | 29936596 | Cell Mol Life Sci | Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. | 2018 | Details |
| A13518 | 29935383 | Biochim Biophys Acta Mol Cell Biol Lipids | The role of PNPLA3 in health and disease. | 2018 | Details |
| A13520 | 29935106 | Mol Nutr Food Res | Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin. | 2018 | Details |
| A13523 | 29931613 | Curr Diab Rep | The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes. | 2018 | Details |
| A13535 | 29925686 | JCI Insight | Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome. | 2018 | Details |
| A13561 | 29909277 | Cell Syst | Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species. | 2018 | Details |
| A13562 | 29909275 | Cell Syst | Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes. | 2018 | Details |
| A13566 | 29906416 | Gastroenterology | Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13572 | 29902703 | Atherosclerosis | Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP. | 2018 | Details |
| A13573 | 29902522 | Cell Signal | Role of cAMP and phosphodiesterase signaling in liver health and disease. | 2018 | Details |
| A13574 | 29902065 | Am J Physiol Gastrointest Liver Physiol | Mesenteric adipose tissue contributes to intestinal barrier integrity and protects against nonalcoholic fatty liver disease in mice. | 2018 | Details |
| A13591 | 29890650 | Foods | Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. | 2018 | Details |
| A13594 | 29890136 | Biochem Biophys Res Commun | Hepatocyte-specific deletion of Brg1 alleviates methionine-and-choline-deficient diet (MCD) induced non-alcoholic steatohepatitis in mice. | 2018 | Details |
| A13602 | 29883718 | Biochim Biophys Acta Mol Basis Dis | Genetically modified mouse models to study hepatic neutral lipid mobilization. | 2018 | Details |
| A13605 | 29881818 | Hepatol Commun | Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease. | 2018 | Details |
| A13622 | 29869810 | Diabet Med | Dulaglutide decreases plasma aminotransferases in people with Type 2 diabetes in a pattern consistent with liver fat reduction: a post hoc analysis of the AWARD programme. | 2018 | Details |
| A13627 | 29864915 | Biomed Pharmacother | Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. | 2018 | Details |
| A13634 | 29860977 | Adv Food Nutr Res | Omega-3 Fatty Acids and Fatty Liver Disease in Children. | 2018 | Details |
| A13652 | 29855396 | J Dev Orig Health Dis | Early onset and progression of non-alcoholic fatty liver disease in young monosodium l-glutamate-induced obese mice. | 2018 | Details |
| A13659 | 29852170 | Biochem Biophys Res Commun | Suppression of NF-κB activation by PDLIM2 restrains hepatic lipogenesis and inflammation in high fat diet induced mice. | 2018 | Details |
| A13667 | 29847571 | PLoS One | ILDR2 has a negligible role in hepatic steatosis. | 2018 | Details |
| A13668 | 29847555 | PLoS One | Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. | 2018 | Details |
| A13677 | 29844588 | Nat Rev Gastroenterol Hepatol | Noninvasive biomarkers in NAFLD and NASH - current progress and future promise. | 2018 | Details |
| A13679 | 29844096 | Diabetes Care | Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. | 2018 | Details |
| A13690 | 29804360 | Zhonghua Gan Zang Bing Za Zhi | [Effect of aerobic exercise and resistance exercise in improving non-alcoholic fatty liver disease: a randomized controlled trial]. | 2018 | Details |
| A13698 | 29802679 | J Diabetes Investig | Soluble CD163 correlates with lipid metabolic adaptations in type 1 diabetes patients during ketoacidosis. | 2018 | Details |
| A13714 | 29795358 | Acta Pharmacol Sin | Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice. | 2018 | Details |
| A13721 | 29792584 | J Dev Orig Health Dis | Neonatal intake of oleanolic acid attenuates the subsequent development of high fructose diet-induced non-alcoholic fatty liver disease in rats. | 2018 | Details |
| A13724 | 29790582 | Hepatology | Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. | 2018 | Details |
| A13725 | 29789866 | Cell Mol Life Sci | Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation. | 2018 | Details |
| A13730 | 29786745 | Int J Mol Med | Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease. | 2018 | Details |
| A13735 | 29785077 | World J Gastroenterol | Mediterranean diet and nonalcoholic fatty liver disease. | 2018 | Details |
| A13740 | 29781841 | Curr Opin Clin Nutr Metab Care | Carbohydrates and diet patterns in nonalcoholic fatty liver disease in children and adolescents. | 2018 | Details |
| A13746 | 29778532 | Biochem Biophys Res Commun | Non-alcoholic fatty liver disease: Insights from sphingolipidomics. | 2018 | Details |
| A13754 | 29773783 | Am J Case Rep | Cholesteryl Ester Storage Disease: Fatal Outcome without Causal Therapy in a Female Patient with the Preventable Sequelae of Progressive Liver Disease after Many Years of Mild Symptoms. | 2018 | Details |
| A13767 | 29766801 | Curr Pharm Biotechnol | Naringenin and its Nano-formulations for Fatty Liver: Cellular Modes of Action and Clinical Perspective. | 2018 | Details |
| A13789 | 29756964 | Nutr Hosp | Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. | 2018 | Details |
| A13796 | 29751292 | J Nutr Biochem | Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance. | 2018 | Details |
| A13805 | 29747118 | J Nutr Biochem | Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice. | 2018 | Details |
| A13814 | 29743929 | Nutr Metab (Lond) | Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. | 2018 | Details |
| A13821 | 29743187 | Mol Pharmacol | Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation. | 2018 | Details |
| A13827 | 29738703 | Chem Biol Interact | High fat diet induced obesity is mitigated in Cyp3a-null female mice. | 2018 | Details |
| A13846 | 29729151 | Wiad Lek | Subclinical hypothyroidism in patients with non-alcoholic fatty liver disease at the background of carbohydrate metabolism disorders. | 2019 | Details |
| A13855 | 29725353 | Evid Based Complement Alternat Med | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract. | 2018 | Details |
| A13861 | 29721023 | Cell Mol Biol Lett | MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1. | 2018 | Details |
| A13867 | 29719598 | Oncotarget | Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver. | 2018 | Details |
| A13868 | 29719529 | Front Endocrinol (Lausanne) | ANGPTL8: An Important Regulator in Metabolic Disorders. | 2018 | Details |
| A13876 | 29713279 | Front Pharmacol | Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation. | 2018 | Details |
| A13879 | 29713125 | World J Gastroenterol | Beneficial effects of naringenin in liver diseases: Molecular mechanisms. | 2018 | Details |
| A13883 | 29710765 | Nutrients | A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice. | 2018 | Details |
| A13889 | 29707653 | Wellcome Open Res | Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD. | 2017 | Details |
| A13893 | 29705240 | J Hepatol | CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis. | 2018 | Details |
| A13894 | 29705134 | Biochimie | Increase in liver cytosolic lipases activities and VLDL-TAG secretion rate do not prevent the non-alcoholic fatty liver disease in cafeteria diet-fed rats. | 2018 | Details |
| A13897 | 29704577 | Food Chem Toxicol | Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids. | 2018 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A13915 | 29696666 | Aliment Pharmacol Ther | Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease. | 2018 | Details |
| A13918 | 29693586 | Nutrients | Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats. | 2018 | Details |
| A13922 | 29690638 | Nutrients | Neurotensin Is a Lipid-Induced Gastrointestinal Peptide Associated with Visceral Adipose Tissue Inflammation in Obesity. | 2018 | Details |
| A13928 | 29684468 | Pharmacol Ther | Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease. | 2018 | Details |
| A13943 | 29678641 | Biochim Biophys Acta Mol Cell Biol Lipids | Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish. | 2018 | Details |
| A13965 | 29666185 | J Biol Chem | Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. | 2018 | Details |
| A13975 | 29662003 | Int J Mol Sci | PPAR Agonists and Metabolic Syndrome: An Established Role? | 2018 | Details |
| A13987 | 29656250 | Environ Pollut | Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat. | 2018 | Details |
| A13989 | 29655677 | Phytomedicine | An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. | 2018 | Details |
| A13995 | 29653185 | Biochim Biophys Acta Mol Basis Dis | Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. | 2018 | Details |
| A13996 | 29653100 | Chem Biol Interact | Vitamin D nanoemulsion enhances hepatoprotective effect of conventional vitamin D in rats fed with a high-fat diet. | 2018 | Details |
| A14000 | 29649907 | Expert Opin Ther Pat | Farnesoid X receptor modulators 2014-present: a patent review. | 2018 | Details |
| A14003 | 29643297 | J Vet Med Sci | Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model. | 2018 | Details |