Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A03638 | 33923255 | Nutrients | Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development. | 2021 | Details |
| A03683 | 33903148 | Gut | Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target. | 2021 | Details |
| A03754 | 33877249 | Food Funct | Pterostilbene modifies triglyceride metabolism in hepatic steatosis induced by high-fat high-fructose feeding: a comparison with its analog resveratrol. | 2021 | Details |
| A03860 | 33841814 | Food Sci Nutr | Functional beverages improve insulin resistance and hepatic steatosis modulating lysophospholipids in diet-induced obese rats. | 2021 | Details |
| A03919 | 33817364 | Heliyon | Inhaled exposure to air fresheners aggravated liver injury in a murine model of nonalcoholic fatty acid liver disease. | 2021 | Details |
| A03952 | 33809593 | Nutrients | Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04011 | 33789906 | Sci Adv | Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders. | 2021 | Details |
| A04016 | 33788377 | Liver Int | Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis. | 2021 | Details |
| A04025 | 33785339 | Life Sci | A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH. | 2021 | Details |
| A04028 | 33785007 | BMC Complement Med Ther | Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats. | 2021 | Details |
| A04159 | 33734012 | Autophagy | MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. | 2021 | Details |
| A04203 | 33716447 | World J Gastroenterol | G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. | 2021 | Details |
| A04231 | 33705945 | J Nutr Biochem | High sucrose diet-induced dysbiosis of gut microbiota promotes fatty liver and hyperlipidemia in rats. | 2021 | Details |
| A04237 | 33693900 | J Nutr | Consumption of High-Fructose Corn Syrup Compared with Sucrose Promotes Adiposity and Increased Triglyceridemia but Comparable NAFLD Severity in Juvenile Iberian Pigs. | 2021 | Details |
| A04294 | 33673227 | Nutrients | Temporal Development of Dyslipidemia and Nonalcoholic Fatty Liver Disease (NAFLD) in Syrian Hamsters Fed a High-Fat, High-Fructose, High-Cholesterol Diet. | 2021 | Details |
| A04296 | 33673073 | Int J Mol Sci | Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-γ Pathway via miR-27b-5p Regulation. | 2021 | Details |
| A04311 | 33670347 | Nutrients | Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile and Macrophage Polarization. | 2021 | Details |
| A04317 | 33667726 | Mol Metab | Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction. | 2021 | Details |
| A04325 | 33665203 | Front Nutr | The Impact of Macronutrient Intake on Non-alcoholic Fatty Liver Disease (NAFLD): Too Much Fat, Too Much Carbohydrate, or Just Too Many Calories? | 2021 | Details |
| A04346 | 33655500 | Br J Pharmacol | Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis. | 2021 | Details |
| A04364 | 33647584 | Cytokine | Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and pFak-NFκB signaling. | 2021 | Details |
| A04388 | 33638902 | Hepatology | Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer. | 2021 | Details |
| A04414 | 33628193 | Front Pharmacol | Fructose and Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A04428 | 33619282 | Nat Commun | Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. | 2021 | Details |
| A04438 | 33616081 | JCI Insight | Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans. | 2021 | Details |
| A04454 | 33609576 | Int J Biol Macromol | Synthesis of a green bigel using cottonseed oil/cannabis oil/alginate/ferula gum for quercetin release: Synergistic effects for treating infertility in rats. | 2021 | Details |
| A04495 | 33596938 | J Transl Med | Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD. | 2021 | Details |
| A04642 | 33554072 | iScience | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation. | 2021 | Details |
| A04651 | 33551215 | Clin Nutr | Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A04654 | 33550112 | Redox Biol | Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase. | 2021 | Details |
| A04658 | 33549451 | Nutr Metab Cardiovasc Dis | Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice. | 2020 | Details |
| A04713 | 33531575 | Sci Rep | High-fructose feeding does not induce steatosis or non-alcoholic fatty liver disease in pigs. | 2021 | Details |
| A04725 | 33526807 | Lab Invest | NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water. | 2021 | Details |
| A04766 | 33512269 | J Med Food | Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats. | 2021 | Details |
| A04820 | 33494295 | Cells | Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways. | 2021 | Details |
| A04831 | 33490936 | JHEP Rep | Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. | 2020 | Details |
| A04861 | 33477939 | Microorganisms | Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A04895 | 33464363 | Eur J Nutr | Relevance of fructose intake in adolescence for fatty liver indices in young adulthood. | 2021 | Details |
| A04916 | 33450094 | J Physiol | Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex-specific manner. | 2021 | Details |
| A04933 | 33444819 | Cell Mol Gastroenterol Hepatol | Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver. | 2021 | Details |
| A04937 | 33444606 | Metabolism | Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters. | 2021 | Details |
| A04992 | 33421970 | Turk J Med Sci | The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease | 2021 | Details |
| A05000 | 33419084 | Antioxidants (Basel) | Antioxidant and Anti-Inflammatory Effects of Korean Black Ginseng Extract through ER Stress Pathway. | 2021 | Details |
| A05023 | 33407877 | Biol Sex Differ | Analysis of sex differences in dietary copper-fructose interaction-induced alterations of gut microbial activity in relation to hepatic steatosis. | 2021 | Details |
| A05027 | 33404569 | Food Funct | The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice. | 2021 | Details |
| A05089 | 33381794 | Am J Clin Nutr | Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial. | 2021 | Details |
| A05177 | 33346069 | Mol Metab | Metabolic drivers of non-alcoholic fatty liver disease. | 2020 | Details |
| A05247 | 33325808 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05284 | 33312845 | Curr Treat Options Pediatr | When the beverage is sweet, how does the liver feel? | 2019 | Details |
| A05312 | 33305889 | Pediatr Obes | The relationship between excessive dietary fructose consumption and paediatric fatty liver disease. | 2020 | Details |
| A05331 | 33299871 | Biomed Res Int | Protective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study. | 2020 | Details |
| A05338 | 33297922 | CNS Neurol Disord Drug Targets | Liver-Brain Axis in Sporadic Alzheimer's Disease: Role of Ten Signature Genes in a Mouse Model. | 2021 | Details |
| A05345 | 33293347 | Diabetes Care | Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05346 | 33292701 | Biomark Res | Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function. | 2020 | Details |
| A05352 | 33289350 | Diabetes Obes Metab | Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. | 2020 | Details |
| A05353 | 33289147 | J Food Biochem | A high-fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism. | 2020 | Details |
| A05414 | 33268508 | Sci Transl Med | Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. | 2020 | Details |
| A05425 | 33261044 | Int J Mol Sci | Soluble Endoglin as a Potential Biomarker of Nonalcoholic Steatohepatitis (NASH) Development, Participating in Aggravation of NASH-Related Changes in Mouse Liver. | 2020 | Details |
| A05475 | 33244884 | J Cachexia Sarcopenia Muscle | Myosteatosis rather than sarcopenia associates with non-alcoholic steatohepatitis in non-alcoholic fatty liver disease preclinical models. | 2020 | Details |
| A05501 | 33228237 | Int J Mol Sci | Nutrients, Genetic Factors, and Their Interaction in Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease. | 2020 | Details |
| A05514 | 33220492 | Mol Metab | Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans. | 2020 | Details |
| A05527 | 33218081 | Biology (Basel) | Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05532 | 33217052 | J Gastroenterol Hepatol | A review of non-alcoholic fatty liver disease in non-obese and lean individuals. | 2020 | Details |
| A05546 | 33212947 | Nutrients | Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05549 | 33211913 | Vopr Pitan | [Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease in Wistar rats]. | 2020 | Details |
| A05614 | 33187278 | Nutrients | The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | 2020 | Details |
| A05628 | 33183606 | Carbohydr Polym | Friend or foe? The roles of inulin-type fructans. | 2020 | Details |
| A05630 | 33182700 | Nutrients | Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases. | 2020 | Details |
| A05650 | 33173107 | Sci Rep | Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression. | 2020 | Details |
| A05722 | 33143061 | Nutrients | Cafeteria Diet and High-Fructose Rodent Models of NAFLD Differ in the Metabolism of Important PUFA and Palmitoleic Acid without Additional Influence of Sex. | 2020 | Details |
| A05744 | 33134908 | JHEP Rep | Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor. | 2020 | Details |
| A05798 | 33114299 | Antioxidants (Basel) | Comparative Effects of Pterostilbene and Its Parent Compound Resveratrol on Oxidative Stress and Inflammation in Steatohepatitis Induced by High-Fat High-Fructose Feeding. | 2020 | Details |
| A05804 | 33113993 | Nutrients | Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation. | 2020 | Details |
| A05858 | 33098092 | Hepatology | Hepatocyte Nuclear Factor 4α Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice). | 2021 | Details |
| A05863 | 33096235 | J Nutr Biochem | Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating AdipoR1 and gp91phox expression in rats. | 2020 | Details |
| A05868 | 33095528 | Cell Physiol Biochem | Palmitate and Fructose Interact to Induce Human Hepatocytes to Produce Pro-Fibrotic Transcriptional Responses in Hepatic Stellate Cells Exposed to Conditioned Media. | 2020 | Details |
| A05876 | 33092030 | Int J Mol Sci | Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. | 2020 | Details |
| A05956 | 33061886 | Food Nutr Res | Cross-sectional analysis of the health profile and dietary intake of a sample of Canadian adults diagnosed with non-alcoholic fatty liver disease. | 2020 | Details |
| A05966 | 33059584 | BMC Gastroenterol | Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose (WDF). | 2020 | Details |
| A05972 | 33057854 | Curr Diab Rep | Tissue-Specific Fructose Metabolism in Obesity and Diabetes. | 2020 | Details |
| A05981 | 33053631 | Nutrients | Microbiota, Fiber, and NAFLD: Is There Any Connection? | 2020 | Details |
| A06000 | 33042259 | Theranostics | Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development. | 2020 | Details |
| A06004 | 33040080 | Cell Death Dis | USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. | 2020 | Details |
| A06028 | 33035588 | Life Sci | Nicotinamide and ascorbic acid nanoparticles against the hepatic insult induced in rats by high fat high fructose diet: A comparative study. | 2020 | Details |
| A06048 | 33028928 | Sci Rep | The effects of fructose and metabolic inhibition on hepatocellular carcinoma. | 2020 | Details |
| A06122 | 32998095 | Diabetes Metab Syndr | Pathophysiological mechanisms underlying MAFLD. | 2020 | Details |
| A06272 | 32945408 | Mol Med Rep | Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats. | 2020 | Details |
| A06320 | 32930541 | Eur J Histochem | β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet. | 2020 | Details |
| A06335 | 32924526 | Am J Physiol Endocrinol Metab | Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease. | 2020 | Details |
| A06369 | 32910646 | J Med Chem | Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. | 2020 | Details |
| A06423 | 32885440 | J Food Sci | Effects of probiotic and prebiotic supplementation on metabolic parameters, liver aminotransferases, and systemic inflammation in nonalcoholic fatty liver disease: A randomized clinical trial. | 2020 | Details |
| A06437 | 32881925 | PLoS One | Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance. | 2020 | Details |
| A06457 | 32875543 | J Physiol Biochem | Metabolite profiling of mice under long-term fructose drinking and vitamin D deficiency: increased risks for metabolic syndrome and nonalcoholic fatty liver disease. | 2020 | Details |
| A06487 | 32859881 | Chin J Physiol | Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease. | 2020 | Details |
| A06505 | 32849604 | Front Immunol | Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice. | 2020 | Details |
| A06506 | 32849314 | Front Endocrinol (Lausanne) | Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs. | 2020 | Details |
| A06522 | 32841505 | Liver Int | Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative. | 2020 | Details |
| A06528 | 32839596 | Nat Metab | Fructose stimulated de novo lipogenesis is promoted by inflammation. | 2020 | Details |
| A06588 | 32818571 | J Hepatol | miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder. | 2020 | Details |