Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A06076 | 33015093 | Front Med (Lausanne) | Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2'-Deoxyguanosine. | 2020 | Details |
| A06095 | 33009206 | J Chin Med Assoc | Genetic variations of three important antioxidative enzymes SOD2, CAT, and GPX1 in nonalcoholic steatohepatitis. | 2021 | Details |
| A06152 | 32985285 | Free Radic Res | Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in Chinese non-diabetic adults: mediation models involving superoxide dismutase. | 2020 | Details |
| A06153 | 32985239 | Nat Prod Res | Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice. | 2020 | Details |
| A06187 | 32976958 | Toxicology | Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease. | 2020 | Details |
| A06454 | 32877213 | Am J Physiol Gastrointest Liver Physiol | High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis. | 2020 | Details |
| A06516 | 32846589 | Food Res Int | Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome. | 2020 | Details |
| A06538 | 32833043 | Arch Toxicol | A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats. | 2020 | Details |
| A06597 | 32812944 | Metabol Open | Regulation of hepatic genes related to lipid metabolism and antioxidant enzymes by sodium butyrate supplementation. | 2020 | Details |
| A06622 | 32804855 | Eur J Gastroenterol Hepatol | Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. | 2021 | Details |
| A06713 | 32772909 | Comb Chem High Throughput Screen | Evaluation of Insulin Resistance Induced Brain Tissue Dysfunction in Obese Dams and their Neonates: Role of Ipriflavone Amelioration. | 2021 | Details |
| A06796 | 32742180 | Saudi J Biol Sci | The effect of hydroalcoholic Berberis integerrima fruits extract on the lipid profile, antioxidant parameters and liver and kidney function tests in patients with nonalcoholic fatty liver disease. | 2020 | Details |
| A06822 | 32734012 | Porto Biomed J | An albino mouse model of nonalcoholic fatty liver disease induced using high-fat liquid "Lieber-DeCarli" diet: a preliminary investigation. | 2020 | Details |
| A06839 | 32728632 | Clin Exp Hepatol | Glutathione S-transferase T1 and M1 null genotype distribution among non-alcoholic fatty liver disease patients and its association with cytokine and adipokine profiles. | 2020 | Details |
| A06924 | 32696189 | Metab Brain Dis | Melatonin regulates neurodegenerative complications associated with NAFLD via enhanced neurotransmission and cellular integrity: a correlational study. | 2020 | Details |
| A07142 | 32604760 | Nutrients | Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. | 2020 | Details |
| A07176 | 32592532 | Phytother Res | Sophoricoside is a selective LXRβ antagonist with potent therapeutic effects on hepatic steatosis of mice. | 2020 | Details |
| A07192 | 32587515 | Front Pharmacol | Integrated Metagenomic and Metabolomic Analyses of the Effect of Astragalus Polysaccharides on Alleviating High-Fat Diet-Induced Metabolic Disorders. | 2020 | Details |
| A07210 | 32581811 | Front Pharmacol | Untargeted Metabolomic Analysis of the Effects and Mechanism of Nuciferine Treatment on Rats With Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07356 | 32526845 | Int J Mol Sci | N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07432 | 32499918 | Gastroenterol Rep (Oxf) | Effect of Helicobacter pylori-eradication therapy on hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomized-controlled pilot study. | 2019 | Details |
| A07473 | 32482167 | BMC Complement Med Ther | Genistein and exercise modulated lipid peroxidation and improved steatohepatitis in ovariectomized rats. | 2020 | Details |
| A07521 | 32460191 | Biomed Pharmacother | Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats. | 2020 | Details |
| A07745 | 32366854 | Sci Rep | Novel Combinatorial Regimen of Garcinol and Curcuminoids for Non-alcoholic Steatohepatitis (NASH) in Mice. | 2020 | Details |
| A07878 | 32325806 | Toxins (Basel) | Development and Application of Extraction Methods for LC-MS Quantification of Microcystins in Liver Tissue. | 2020 | Details |
| A07901 | 32317079 | BMB Rep | GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress. | 2020 | Details |
| A07918 | 32310756 | J Pharm Pharm Sci | Gamma glutamyl transferase - an underestimated marker for cardiovascular disease and the metabolic syndrome. | 2020 | Details |
| A07938 | 32304952 | Environ Pollut | Exposure to 2,3,3',4,4',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice. | 2020 | Details |
| A07947 | 32302728 | J Hepatol | Exercise retards hepatocarcinogenesis in obese mice independently of weight control. | 2020 | Details |
| A08026 | 32277923 | Mol Metab | Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model. | 2020 | Details |
| A08077 | 32256346 | Front Pharmacol | Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression. | 2020 | Details |
| A08098 | 32245940 | Med Sci Monit | Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway. | 2020 | Details |
| A08119 | 32240652 | Biochem Pharmacol | Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: Insight on hedgehog/Gli and Wnt/β-catenin signaling crosstalk. | 2020 | Details |
| A08313 | 32156377 | Food Res Int | Effect of okra fruit powder supplementation on metabolic syndrome and gut microbiota diversity in high fat diet-induced obese mice. | 2019 | Details |
| A08497 | 32086249 | Biol Open | Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats. | 2020 | Details |
| A08499 | 32085637 | Nutrients | A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet. | 2020 | Details |
| A08501 | 32084378 | Cell Metab | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | 2020 | Details |
| A08502 | 32083947 | Can J Physiol Pharmacol | Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study. | 2020 | Details |
| A08505 | 32083445 | Horm Mol Biol Clin Investig | Hepatoprotective effects of Shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. | 2020 | Details |
| A08525 | 32074961 | Nutrients | Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A08555 | 32062620 | J Toxicol Sci | Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease. | 2020 | Details |
| A08593 | 32046101 | Int J Mol Sci | Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A08706 | 32017057 | Eur J Clin Invest | Systemic redox imbalance in patients with nonalcoholic fatty liver disease. | 2020 | Details |
| A08868 | 31956867 | Food Funct | High fat diet incorporated with meat proteins changes biomarkers of lipid metabolism, antioxidant activities, and the serum metabolomic profile in Glrx1-/- mice. | 2020 | Details |
| A08983 | 31915635 | Prev Nutr Food Sci | Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats. | 2019 | Details |
| A08991 | 31913745 | Autophagy | SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. | 2020 | Details |
| A09152 | 31857090 | Chem Biol Interact | Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity. | 2019 | Details |
| A09156 | 31853615 | Naunyn Schmiedebergs Arch Pharmacol | Adelmidrol protects against non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A09263 | 31813265 | Antioxid Redox Signal | Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. | 2020 | Details |
| A09290 | 31804025 | Environ Toxicol | Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis. | 2019 | Details |
| A09627 | 31670060 | Pharmacol Rep | Hepatoprotective potential of 7,8-Dihydroxyflavone against alcohol and high-fat diet induced liver toxicity via attenuation of oxido-nitrosative stress and NF-κB activation. | 2019 | Details |
| A09628 | 31669275 | Int J Biol Macromol | Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress. | 2019 | Details |
| A09681 | 31650383 | Mol Biol Rep | High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes. | 2019 | Details |
| A09705 | 31638270 | Clin Pharmacol Ther | Acetaminophen-Induced Liver Damage in Hepatic Steatosis. | 2019 | Details |
| A09728 | 31632961 | Front Cell Dev Biol | NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09787 | 31610178 | Am J Pathol | Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation-Mediated Cell Death in Mice. | 2019 | Details |
| A09970 | 31540081 | Nutrients | Dietary Supplementation with Hazelnut Oil Reduces Serum Hyperlipidemia and Ameliorates the Progression of Nonalcoholic Fatty Liver Disease in Hamsters Fed a High-Cholesterol Diet. | 2019 | Details |
| A10087 | 31493247 | Hormones (Athens) | Selenium and selenoprotein P in nonalcoholic fatty liver disease. | 2019 | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | 2019 | Details |
| A10101 | 31484072 | Cell Rep | Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. | 2019 | Details |
| A10103 | 31483669 | J Proteome Res | High Throughput Screening of Serum γ-Glutamyl Dipeptides for Risk Assessment of Nonalcoholic Steatohepatitis with Impaired Glutathione Salvage Pathway. | 2019 | Details |
| A10175 | 31452288 | Phytother Res | Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice. | 2019 | Details |
| A10196 | 31438528 | Mar Drugs | Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation. | 2019 | Details |
| A10212 | 31430456 | Eur J Pharmacol | Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. | 2019 | Details |
| A10215 | 31428351 | Food Sci Nutr | Lactobacillus paracasei Jlus66 extenuate oxidative stress and inflammation via regulation of intestinal flora in rats with non alcoholic fatty liver disease. | 2019 | Details |
| A10329 | 31387169 | Biomed Pharmacother | Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum. | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10354 | 31378768 | J Toxicol Sci | Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats. | 2019 | Details |
| A10484 | 31316716 | Oxid Med Cell Longev | Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model. | 2019 | Details |
| A10692 | 31234658 | Free Radic Res | Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients. | 2019 | Details |
| A10756 | 31208147 | Nutrients | Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. | 2019 | Details |
| A10759 | 31207429 | Pharmacol Rep | Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin. | 2019 | Details |
| A10866 | 31150631 | Chem Biol Interact | β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats. | 2019 | Details |
| A10871 | 31147590 | Sci Rep | Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD. | 2019 | Details |
| A11129 | 31030165 | J Nutr Biochem | Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. | 2019 | Details |
| A11195 | 31004566 | Biochem Pharmacol | Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors. | 2019 | Details |
| A11247 | 30974975 | Hum Exp Toxicol | Aromatic aldehyde compound cuminaldehyde protects nonalcoholic fatty liver disease in rats feeding high fat diet. | 2019 | Details |
| A11293 | 30951700 | Exp Mol Pathol | The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH). | 2019 | Details |
| A11308 | 30945501 | Zhen Ci Yan Jiu | [Acupuncture improves hepatic lipid metabolism by suppressing oxidative stress in obese nonalcoholic fatty liver disease rats]. | 2019 | Details |
| A11316 | 30942432 | Int J Mol Med | Oxaliplatin aggravates hepatic oxidative stress, inflammation and fibrosis in a non‑alcoholic fatty liver disease mouse model. | 2019 | Details |
| A11392 | 30915409 | Clin Exp Hepatol | Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats. | 2019 | Details |
| A11411 | 30905786 | Biochim Biophys Acta Mol Basis Dis | Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation. | 2019 | Details |
| A11507 | 30867696 | Exp Ther Med | Berberine attenuates hepatic oxidative stress in rats with non-alcoholic fatty liver disease via the Nrf2/ARE signalling pathway. | 2019 | Details |
| A11592 | 30826497 | Life Sci | Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats. | 2019 | Details |
| A11645 | 30807179 | J Proteome Res | Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. | 2019 | Details |
| A11771 | 30757944 | Pharm Biol | Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat. | 2019 | Details |
| A11806 | 30732555 | Eur J Sport Sci | Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. | 2019 | Details |
| A11823 | 30720104 | Mol Med Rep | Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet. | 2019 | Details |
| A11859 | 30706422 | Drugs | L-Ornithine L-Aspartate (LOLA) as a Novel Approach for Therapy of Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A11898 | 30689994 | Eur J Pharmacol | Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease. | 2019 | Details |
| A11910 | 30684890 | Redox Biol | Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity. | 2018 | Details |
| A12089 | 30606929 | Yakugaku Zasshi | [A Multifaceted Approach regarding the Association of the DsbA-L Gene with the Risk of Obesity-related Diseases Based on Clinical Pharmacogenetics]. | 2019 | Details |
| A12152 | 30580553 | Crit Rev Food Sci Nutr | n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. | 2018 | Details |
| A12194 | 30567393 | Int J Mol Sci | Tunicamycin-Induced ER Stress is Accompanied with Oxidative Stress via Abrogation of Sulfur Amino Acids Metabolism in the Liver. | 2018 | Details |
| A12326 | 30515395 | Biomed Res Int | Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients. | 2018 | Details |
| A12509 | 30415113 | Chemosphere | Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction. | 2018 | Details |
| A12577 | 30381838 | J Physiol | SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. | 2018 | Details |
| A12586 | 30375253 | Pharm Biol | Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats. | 2018 | Details |