Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Polyunsaturated Fatty Acids353 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A13069 | 30153476 | Free Radic Biol Med | Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. | 2018 | Details |
| A13089 | 30142943 | Nutrients | Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. | 2018 | Details |
| A13141 | 30120404 | Pediatr Res | In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children. | 2018 | Details |
| A13336 | 30026586 | Sci Rep | Substitution of linoleic acid with α-linolenic acid or long chain n-3 polyunsaturated fatty acid prevents Western diet induced nonalcoholic steatohepatitis. | 2018 | Details |
| A13397 | 29998870 | Indian J Med Res | Erythrocyte membrane fatty acid profile & serum cytokine levels in patients with non-alcoholic fatty liver disease. | 2018 | Details |
| A13400 | 29996339 | Zhonghua Gan Zang Bing Za Zhi | [Effect of lipid-induced macrophage M1/M2 polarization on lipid metabolism in hepatocytes]. | 2018 | Details |
| A13497 | 29947894 | Arch Toxicol | Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126. | 2018 | Details |
| A13548 | 29917092 | Nutr Rev | Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease. | 2018 | Details |
| A13615 | 29873593 | Metab Syndr Relat Disord | Variation in the Plasma Levels of Polyunsaturated Fatty Acids in Control vis-à-vis Nonalcoholic Fatty Liver Disease Subjects and Its Possible Association with Gut Microbiome. | 2018 | Details |
| A13628 | 29864682 | J Nutr Biochem | Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids. | 2018 | Details |
| A13656 | 29853957 | Evid Based Complement Alternat Med | Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A13708 | 29798686 | Syst Biol Reprod Med | Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. | 2018 | Details |
| A13946 | 29675558 | Eur J Nutr | Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals. | 2018 | Details |
| A14007 | 29641459 | Molecules | An Overview of Novel Dietary Supplements and Food Ingredients in Patients with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A14103 | 29583004 | J Agric Food Chem | Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. | 2018 | Details |
| A14121 | 29574608 | Eur J Nutr | Fish intake interacts with TM6SF2 gene variant to affect NAFLD risk: results of a case-control study. | 2018 | Details |
| A14167 | 29555681 | J Biol Chem | Patatin-like phospholipase domain–containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. | 2018 | Details |
| A14469 | 29398867 | World J Gastroenterol | Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice. | 2018 | Details |
| A14485 | 29389988 | PLoS One | Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis. | 2018 | Details |
| A14730 | 29268121 | J Nutr Biochem | Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat. | 2017 | Details |
| A14762 | 29249532 | Clin Nutr | Omega-3 PUFA modulate lipogenesis, ER stress, and mitochondrial dysfunction markers in NASH - Proteomic and lipidomic insight. | 2017 | Details |
| A14902 | 29182572 | Int J Mol Sci | Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics. | 2017 | Details |
| A14912 | 29175671 | J Nutr Biochem | Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology. | 2017 | Details |
| A14917 | 29175182 | Food Chem Toxicol | Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. | 2017 | Details |
| A14975 | 29149647 | J Nutr Biochem | Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding. | 2017 | Details |
| A15000 | 29129237 | Nutrition | Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. | 2017 | Details |
| A15013 | 29128056 | Clin Liver Dis | Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15022 | 29126901 | Biochim Biophys Acta Mol Cell Biol Lipids | Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120). | 2017 | Details |
| A15133 | 29081885 | Oxid Med Cell Longev | Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. | 2017 | Details |
| A15167 | 29065507 | Nutrients | Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders. | 2017 | Details |
| A15168 | 29065499 | Diseases | An Overview of Dietary Interventions and Strategies to Optimize the Management of Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A15306 | 28972610 | Food Funct | fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease. | 2017 | Details |
| A15346 | 28954437 | Nutrients | Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. | 2017 | Details |
| A15380 | 28937599 | Nutrients | Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A15760 | 28723414 | Pharmacol Ther | Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease. | 2017 | Details |
| A15777 | 28714405 | Curr Pharm Des | Emerging Targets to Relieve Fat Stress-Induced Liver Diseases: UDCA, Tocotrienol, ω-3 PUFAs, and IgY Targeted NPC1L1 Cholesterol Transporter. | 2017 | Details |
| A15875 | 28676020 | Curr Vasc Pharmacol | Current and Potential Future Pharmacological Approaches for Non- Alcoholic Fatty Liver Disease. | 2018 | Details |
| A16046 | 28595185 | Ann Nutr Metab | Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy. | 2017 | Details |
| A16134 | 28545368 | Curr Med Chem | Improving Metabolic Control Through Functional Foods. | 2019 | Details |
| A16285 | 28471490 | Br J Pharmacol | Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease. | 2017 | Details |
| A16429 | 28395666 | Lipids Health Dis | Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. | 2017 | Details |
| A16442 | 28386616 | Food Funct | Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. | 2017 | Details |
| A16495 | 28356106 | Lipids Health Dis | Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. | 2017 | Details |
| A16500 | 28351093 | Horm Metab Res | ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. | 2017 | Details |
| A16520 | 28341541 | Mol Aspects Med | Pro-resolving actions of SPM in adipose tissue biology. | 2017 | Details |
| A16575 | 28298542 | J Nutr | Lipid Emulsion Added to a Liquid High-Carbohydrate Diet and Voluntary Running Exercise Reduce Lipogenesis and Ameliorate Early-Stage Hepatic Steatosis in Mice. | 2017 | Details |
| A16591 | 28294699 | J Med Food | Chia Oil-Enriched Restructured Pork Effects on Oxidative and Inflammatory Status of Aged Rats Fed High Cholesterol/High Fat Diets. | 2017 | Details |
| A16593 | 28294174 | Eur J Clin Nutr | Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. | 2017 | Details |
| A16700 | 28235613 | J Hepatol | Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. | 2017 | Details |
| A16808 | 28161092 | Clin Nutr | Fatty acid and non-alcoholic fatty liver disease: Meta-analyses of case-control and randomized controlled trials. | 2017 | Details |
| A16833 | 28139281 | Clin Nutr | Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. | 2017 | Details |
| A17020 | 28040302 | Clin Nutr | Omega-3 fatty acids as a treatment for non-alcoholic fatty liver disease in children: A systematic review and meta-analysis of randomized controlled trials. | 2016 | Details |
| A17078 | 28003715 | J Clin Exp Hepatol | High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice. | 2016 | Details |
| A17184 | 27923447 | Metabolism | Amelioration of non-alcoholic fatty liver disease with NPC1L1-targeted IgY or n-3 polyunsaturated fatty acids in mice. | 2016 | Details |
| A17220 | 27906700 | Curr Opin Clin Nutr Metab Care | Update on lipid species and paediatric nonalcoholic fatty liver disease. | 2017 | Details |
| A17406 | 27801862 | Nutrients | Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. | 2016 | Details |
| A17432 | 27710160 | Metab Syndr Relat Disord | Treatment of Nonalcoholic Fatty Liver Disease with Long-Chain n-3 Polyunsaturated Fatty Acids in Humans. | 2016 | Details |
| A17621 | 27711128 | PLoS One | Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials. | 2016 | Details |
| A17663 | 27679530 | J Biol Chem | Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. | 2016 | Details |
| A17692 | 27651787 | Gastroenterol Res Pract | Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis. | 2016 | Details |
| A17905 | 27485440 | Nutr J | Role of bioactive fatty acids in nonalcoholic fatty liver disease. | 2016 | Details |
| A17908 | 27484357 | Int J Food Sci Nutr | Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection. | 2016 | Details |
| A18009 | 27418954 | Oxid Med Cell Longev | Euterpe edulis Extract but Not Oil Enhances Antioxidant Defenses and Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Rats. | 2016 | Details |
| A18116 | 27344166 | Mol Cell Biochem | Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver. | 2016 | Details |
| A18131 | 27333187 | PLoS One | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2016 | Details |
| A18402 | 27155918 | J Nutr Biochem | Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. | 2016 | Details |
| A18574 | 27051672 | Biomed Res Int | Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis. | 2016 | Details |
| A18598 | 27040343 | Yakugaku Zasshi | [A Future Perspective on the Involvement of n-3 Polyunsaturated Fatty Acid in the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis]. | 2016 | Details |
| A18661 | 27006654 | Gastroenterol Res Pract | A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD. | 2016 | Details |
| A18791 | 26937141 | World J Gastroenterol | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | Details |
| A18983 | 26832365 | Lipids Health Dis | Fish oil alleviated high-fat diet-induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study. | 2016 | Details |
| A19047 | 26805014 | Metabolism | Exercise and diet in the management of nonalcoholic fatty liver disease. | 2015 | Details |
| A19067 | 26786351 | Int J Obes (Lond) | Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention. | 2016 | Details |
| A19108 | 26761430 | PLoS One | Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? | 2016 | Details |
| A19190 | 28332698 | Mol Med | Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. | 2017 | Details |
| A19232 | 26683215 | Endocr Dev | Docosahexaenoic Acid and Its Role in G-Protein-Coupled Receptor 120 Activation in Children Affected by Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19338 | 26621325 | J Diabetes | Soluble epoxide hydrolase: A potential target for metabolic diseases. | 2016 | Details |
| A19412 | 26583036 | Nutr Metab (Lond) | Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content. | 2015 | Details |
| A19442 | 26567194 | Adv Nutr | Potential for dietary ω-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. | 2015 | Details |
| A19460 | 26556989 | World J Gastroenterol | Gut microbiota and host metabolism in liver cirrhosis. | 2015 | Details |
| A19521 | 26512643 | Int J Mol Sci | Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease. | 2015 | Details |
| A19589 | 26471014 | Food Funct | Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected to high-fat diet. | 2016 | Details |
| A19599 | 26463349 | Crit Rev Clin Lab Sci | Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD. | 2015 | Details |
| A19657 | 26433072 | Mol Cell Endocrinol | Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction. | 2015 | Details |
| A19745 | 26378648 | Semin Liver Dis | Pharmacotherapy for Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19835 | 26316434 | J Clin Res Pediatr Endocrinol | Long-Term Treatment with n-3 Polyunsaturated Fatty Acids as a Monotherapy in Children with Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A20123 | 26140000 | World J Gastroenterol | Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology. | 2015 | Details |
| A20175 | 26108973 | Eur J Clin Invest | Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD. | 2015 | Details |
| A20280 | 26047766 | Clin Nutr | Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial. | 2015 | Details |
| A20371 | 26005678 | Hepatobiliary Surg Nutr | The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease. | 2015 | Details |
| A20557 | 25889212 | J Transl Med | Docosahexaenoic acid and non-alcoholic fatty liver disease in obese children: a novel approach? | 2015 | Details |
| A20610 | 25852263 | World J Gastroenterol | Current pharmacological therapies for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2015 | Details |
| A20986 | 25601465 | Curr Mol Med | Understanding nutritional interventions and physical exercise in non-alcoholic fatty liver disease. | 2015 | Details |
| A21007 | 25581263 | Hepatology | Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. | 2015 | Details |
| A21457 | 25307311 | Mini Rev Med Chem | Long chain omega-3 polyunsaturated fatty acids in pediatric metabolic syndrome. | 2014 | Details |
| A21568 | 25222487 | PLoS One | Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. | 2014 | Details |
| A21599 | 25195547 | J Hepatol | Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. | 2014 | Details |
| A21732 | 25083925 | Prog Lipid Res | Recent advances in pharmacotherapy for hypertriglyceridemia. | 2014 | Details |
| A21760 | 25065280 | Arch Iran Med | Regulation of adipokines by polyunsaturated fatty acids in a rat model of non-alcoholic steatohepatitis. | 2014 | Details |
| A21964 | 24927647 | J Diabetes Complications | Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease. | 2014 | Details |