Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Rapamycin222 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14790 | 29232555 | Cancer Cell | mTORC2 Promotes Tumorigenesis via Lipid Synthesis. | 2017 | Details |
| A15145 | 29074727 | Gut | Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. | 2017 | Details |
| A15164 | 29066349 | Biochem Biophys Res Commun | Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model. | 2017 | Details |
| A15247 | 29024899 | Biomed Pharmacother | Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation in high-fat-diet induced mice. | 2017 | Details |
| A15473 | 28888852 | Mol Genet Metab | Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. | 2017 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16080 | 28580278 | Mol Metab | FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis. | 2017 | Details |
| A16085 | 28578014 | Free Radic Biol Med | Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway. | 2017 | Details |
| A16318 | 28462076 | Mol Metab | Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis. | 2017 | Details |
| A16362 | 28437863 | Hepatology | Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. | 2017 | Details |
| A16745 | 28212548 | Oncotarget | Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A16805 | 28163011 | Obes Res Clin Pract | Aerobic endurance training improves nonalcoholic fatty liver disease (NAFLD) features via miR-33 dependent autophagy induction in high fat diet fed mice. | 2017 | Details |
| A17326 | 27843095 | EBioMedicine | Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. | 2016 | Details |
| A17453 | 27672081 | J Pharmacol Exp Ther | Akebia Saponin D Decreases Hepatic Steatosis through Autophagy Modulation. | 2016 | Details |
| A17880 | 27501771 | Br J Nutr | Differences in metabolic biomarkers in the blood and gene expression profiles of peripheral blood mononuclear cells among normal weight, mildly obese and moderately obese subjects. | 2016 | Details |
| A17897 | 27492505 | Hepatol Res | Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling pathway. | 2016 | Details |
| A18012 | 27417217 | J Hepatol | Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy. | 2016 | Details |
| A18029 | 27404485 | FEBS Lett | p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. | 2016 | Details |
| A18639 | 27019638 | Int J Biol Sci | Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury. | 2016 | Details |
| A18810 | 26926384 | Hepatology | Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. | 2016 | Details |
| A18915 | 26871756 | Can J Physiol Pharmacol | The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. | 2015 | Details |
| A18964 | 26846206 | Sci Rep | Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation. | 2016 | Details |
| A19126 | 26743335 | Nat Commun | mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. | 2016 | Details |
| A19229 | 26687947 | Biochem Biophys Res Commun | Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis. | 2015 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19391 | 26593434 | Eur J Pharmacol | Protective role of autophagy in methionine-choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice. | 2015 | Details |
| A19818 | 26329041 | Cell Physiol Biochem | Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition. | 2015 | Details |
| A19867 | 26297911 | Biochem Pharmacol | A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression. | 2015 | Details |
| A20122 | 26140084 | World J Hepatol | Systematic review: Preventive and therapeutic applications of metformin in liver disease. | 2015 | Details |
| A20283 | 26046396 | Nutrients | Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis. | 2015 | Details |
| A20292 | 26042770 | PLoS One | mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). | 2015 | Details |
| A20916 | 25646773 | PLoS One | Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. | 2015 | Details |
| A20949 | 25622557 | Int J Biochem Cell Biol | Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. | 2015 | Details |
| A21198 | 25484077 | Autophagy | Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. | 2015 | Details |
| A21643 | 25157160 | Proc Natl Acad Sci U S A | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway. | 2014 | Details |
| A21782 | 25048611 | PLoS One | Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway. | 2014 | Details |
| A21792 | 25043405 | Hepatology | Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. | 2014 | Details |
| A21815 | 25026599 | Biochem Pharmacol | Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. | 2014 | Details |
| A21947 | 24946279 | J Hepatol | ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. | 2014 | Details |
| A21993 | 24904743 | Cell Biosci | Autophagy protects against palmitate-induced apoptosis in hepatocytes. | 2014 | Details |
| A22216 | 24743734 | Cell Death Dis | Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. | 2014 | Details |
| A22295 | 24685479 | Biochem Biophys Res Commun | Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis. | 2014 | Details |
| A22404 | 24608675 | Acta Pharmacol Sin | Palmitic acid induces autophagy in hepatocytes via JNK2 activation. | 2014 | Details |
| A22507 | 24506864 | Cell Metab | The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. | 2014 | Details |
| A22834 | 24275070 | Toxicol Appl Pharmacol | Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. | 2013 | Details |
| A23083 | 24055888 | Biochim Biophys Acta | tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation. | 2013 | Details |
| A23216 | 23951244 | PLoS One | Metformin protects rat hepatocytes against bile acid-induced apoptosis. | 2013 | Details |
| A23245 | 23929677 | Hepatology | Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. | 2014 | Details |
| A23356 | 23845075 | Curr Diabetes Rev | The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. | 2013 | Details |
| A23690 | 23562079 | Cell Metab | Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. | 2013 | Details |
| A23838 | 23435355 | Biochem Pharmacol | Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. | 2013 | Details |
| A23970 | 23339953 | J Hepatol | Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. | 2013 | Details |
| A24669 | 22628617 | J Lipid Res | Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. | 2012 | Details |
| A24833 | 22449814 | Curr Opin Lipidol | Connecting mTORC1 signaling to SREBP-1 activation. | 2012 | Details |
| A25107 | 22166573 | Ann Hepatol | An unusual cause of cancer mimicry following liver transplantation. | 2012 | Details |
| A25753 | 21479224 | PLoS One | Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation. | 2011 | Details |
| A25776 | 21472332 | Mol Med Rep | Mammalian target of the rapamycin pathway is involved in non-alcoholic fatty liver disease. | 2010 | Details |
| A26351 | 20607654 | Histol Histopathol | A role for mammalian target of rapamycin (mTOR) pathway in non alcoholic steatohepatitis related-cirrhosis. | 2010 | Details |
| A26689 | 19948145 | Curr Biol | An emerging role of mTOR in lipid biosynthesis. | 2009 | Details |
| A27711 | 17596878 | Hepatology | A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. | 2007 | Details |
| A28741 | 35076948 | Hepatology | Therapeutic efficacy of FASN inhibition in preclinical models of HCC. | 2022 | Details |
| A30315 | 32655233 | J Clin Exp Hepatol | Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience. | 2019 | Details |
| A30438 | 32443737 | Cancers (Basel) | Molecular Mechanisms Regulating Obesity-Associated Hepatocellular Carcinoma. | 2020 | Details |
| A31455 | 30523261 | Nat Commun | An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. | 2018 | Details |
| A31486 | 30469530 | Cancers (Basel) | mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans. | 2018 | Details |
| A32083 | 29234200 | J Clin Exp Hepatol | Nutrition and Muscle in Cirrhosis. | 2017 | Details |
| A33907 | 24910242 | Cell Metab | Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. | 2014 | Details |
| A34110 | 26709386 | Mol Cell Oncol | TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. | 2014 | Details |
| A34160 | 24273738 | Redox Biol | Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. | 2013 | Details |
| A34310 | 23793039 | Food Chem Toxicol | Nuclear erythroid 2-related factor 2: a novel potential therapeutic target for liver fibrosis. | 2013 | Details |
| A34355 | 23665184 | J Hepatol | Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. | 2013 | Details |
| A35409 | 20815019 | Hepatology | Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. | 2010 | Details |
| A42456 | 34486131 | Alcohol Clin Exp Res | Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. | 2021 | Details |
| A42495 | 34378991 | Am J Physiol Cell Physiol | Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes. | 2021 | Details |
| A42706 | 33693864 | J Nutr | Milk Fat Globule Membrane Supplementation During Suckling Ameliorates Maternal High Fat Diet-Induced Hepatic Steatosis in Adult Male Offspring of Mice. | 2021 | Details |
| A43591 | 31337282 | Thyroid | A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. | 2019 | Details |
| A43722 | 31023527 | Biochem Biophys Res Commun | Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK). | 2019 | Details |
| A43783 | 30890204 | Gene Expr | Sterol 12α-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15. | 2019 | Details |
| A43840 | 30734689 | Endocr Metab Immune Disord Drug Targets | Silibinin Ameliorates Fructose-induced Lipid Accumulation and Activates Autophagy in HepG2 Cells. | 2019 | Details |
| A44034 | 30078211 | J Cell Physiol | Cellular senescence: Molecular mechanisms and pathogenicity. | 2018 | Details |
| A44262 | 29207074 | Mol Med Rep | Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout. | 2017 | Details |
| A44533 | 28323964 | Endocrinology | Dysregulated Autophagy in Hepatocytes Promotes Bisphenol A-Induced Hepatic Lipid Accumulation in Male Mice. | 2017 | Details |
| A45312 | 25230688 | Mol Med Rep | Liraglutide reduces lipid accumulation in steatotic L‑02 cells by enhancing autophagy. | 2014 | Details |
| A45960 | 21841000 | J Biol Chem | L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. | 2011 | Details |
| A45994 | 21701901 | Hepatol Int | Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice. | 2011 | Details |
| A46919 | 34267188 | Cell Death Dis | Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. | 2021 | Details |
| A47019 | 29457836 | Hepatology | DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. | 2018 | Details |
| A47021 | 29368944 | Am J Physiol Gastrointest Liver Physiol | A specific amino acid formula prevents alcoholic liver disease in rodents. | 2018 | Details |
| A47198 | 23274539 | Food Chem Toxicol | α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway. | 2012 | Details |
| A47260 | 20659474 | Gastroenterology | Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. | 2010 | Details |
| A47740 | 32650991 | Transplant Proc | Metabolic and Renal Effects of Mammalian Target of Rapamycin Inhibitors Treatment After Liver Transplantation: Real-Life Single-Center Experience. | 2020 | Details |
| A48693 | 31401190 | Biochimie | Apolipoprotein A-I improves hepatic autophagy through the AMPK pathway. | 2019 | Details |
| A48713 | 30917505 | Int J Mol Sci | Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin. | 2019 | Details |
| A48788 | 28715695 | Eur J Cancer | New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. | 2017 | Details |
| A48969 | 22873368 | Curr Cancer Drug Targets | mTor as a potential target for the prevention and treatment of hepatocellular carcinoma. | 2012 | Details |
| A49078 | 18805482 | Biochim Biophys Acta | Mallory-Denk-bodies: lessons from keratin-containing hepatic inclusion bodies. | 2008 | Details |
| A49754 | 35646540 | Acta Pharm Sin B | Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases. | 2021 | Details |
| A49833 | 35625599 | Biomolecules | Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases. | 2022 | Details |
| A49920 | 35595819 | Cell Mol Immunol | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver. | 2022 | Details |
| A50069 | 35536225 | J Agric Food Chem | Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation. | 2022 | Details |