Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08460 | 32103588 | Mol Nutr Food Res | Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases. | 2020 | Details |
| A08501 | 32084378 | Cell Metab | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | 2020 | Details |
| A08575 | 32054840 | Cell Death Dis | Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. | 2020 | Details |
| A08689 | 32020874 | BMC Complement Med Ther | Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats. | 2020 | Details |
| A08747 | 32002713 | Inflammation | Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. | 2020 | Details |
| A08755 | 32000066 | Biomed Pharmacother | Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages. | 2020 | Details |
| A08833 | 31972071 | Cell Physiol Biochem | Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model. | 2020 | Details |
| A08953 | 31926991 | Eur J Pharmacol | Caveolin-1 alleviates lipid accumulation in NAFLD associated with promoting autophagy by inhibiting the Akt/mTOR pathway. | 2020 | Details |
| A09150 | 31857389 | J Lipid Res | Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09309 | 31796646 | Aging (Albany NY) | HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway. | 2019 | Details |
| A09313 | 31795130 | Nutrients | Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes. | 2019 | Details |
| A09317 | 31793207 | J Cell Mol Med | PNPLA3 I148M mediates the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells. | 2019 | Details |
| A09333 | 31787541 | Ann Hepatol | The preventive effect of liraglutide on the lipotoxic liver injury via increasing autophagy. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09400 | 31760070 | J Hepatol | Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. | 2019 | Details |
| A09403 | 31759065 | Food Chem Toxicol | Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly. | 2019 | Details |
| A09539 | 31702809 | Mol Med Rep | Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet. | 2019 | Details |
| A09603 | 31678070 | Metabolism | Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. | 2019 | Details |
| A09613 | 31674780 | J Agric Food Chem | γ-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells. | 2019 | Details |
| A09801 | 31604805 | J Lipid Res | Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis. | 2019 | Details |
| A09848 | 31592078 | Hepatol Commun | Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics. | 2019 | Details |
| A10020 | 31522189 | Am J Case Rep | Sugar and the Mosaic of Autoimmunity. | 2019 | Details |
| A10023 | 31521175 | Lipids Health Dis | Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities. | 2019 | Details |
| A10133 | 31472960 | Biochem Biophys Res Commun | Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism. | 2019 | Details |
| A10138 | 31470861 | Lipids Health Dis | TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population. | 2019 | Details |
| A10152 | 31467308 | Sci Rep | High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver. | 2019 | Details |
| A10163 | 31463669 | J Nat Med | Cynandione A from Cynanchum wilfordii inhibits hepatic de novo lipogenesis by activating the LKB1/AMPK pathway in HepG2 cells. | 2019 | Details |
| A10254 | 31409773 | Cell Death Dis | mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma. | 2019 | Details |
| A10299 | 31393851 | J Clin Invest | Degradation of splicing factor SRSF3 contributes to progressive liver disease. | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10435 | 31336926 | Nutrients | The Potential Use of Metabolic Cofactors in Treatment of NAFLD. | 2019 | Details |
| A10445 | 31334443 | Hepatol Commun | Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8. | 2019 | Details |
| A10630 | 31263038 | J Immunol | Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages. | 2019 | Details |
| A10673 | 31242974 | Biochem Biophys Res Commun | Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mTOR pathway. | 2019 | Details |
| A10695 | 31233775 | J Control Release | The hepatic-targeted, resveratrol loaded nanoparticles for relief of high fat diet-induced nonalcoholic fatty liver disease. | 2019 | Details |
| A10699 | 31233505 | PLoS One | Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats. | 2019 | Details |
| A10807 | 31180545 | Mol Med Rep | LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. | 2019 | Details |
| A10820 | 31173506 | FASEB J | Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans. | 2019 | Details |
| A10903 | 31132314 | J Gastroenterol Hepatol | Decrease in fat de novo synthesis and chemokine ligand expression in non-alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain-like pseudokinase. | 2019 | Details |
| A11084 | 31051106 | Cell | Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. | 2019 | Details |
| A11090 | 31046673 | Mol Med | Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. | 2019 | Details |
| A11129 | 31030165 | J Nutr Biochem | Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. | 2019 | Details |
| A11302 | 30948912 | World J Gastroenterol | Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. | 2019 | Details |
| A11350 | 30927369 | Br J Pharmacol | Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21. | 2019 | Details |
| A11538 | 30851741 | Lipids Health Dis | TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population. | 2019 | Details |
| A11543 | 30850619 | Sci Rep | Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters - an animal model of life style intervention in NAFLD. | 2019 | Details |
| A11556 | 30841536 | Int J Mol Sci | mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars. | 2019 | Details |
| A11670 | 30796508 | Eur J Nutr | Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. | 2019 | Details |
| A11676 | 30793717 | Food Funct | Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention. | 2019 | Details |
| A11777 | 30753863 | Eur J Pharmacol | Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. | 2019 | Details |
| A11865 | 30704899 | Mol Cell | Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. | 2019 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A12051 | 30622377 | World J Gastroenterol | Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. | 2018 | Details |
| A12053 | 30621707 | Lipids Health Dis | Plasma lipidomic signatures of spontaneous obese rhesus monkeys. | 2019 | Details |
| A12108 | 30599260 | Free Radic Biol Med | Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress. | 2018 | Details |
| A12166 | 30576769 | Cell Mol Gastroenterol Hepatol | Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12181 | 30573200 | Arch Med Res | Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models. | 2018 | Details |
| A12183 | 30572631 | Int J Mol Sci | Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model. | 2018 | Details |
| A12206 | 30562559 | Biochim Biophys Acta Mol Basis Dis | Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice. | 2018 | Details |
| A12255 | 30544824 | Int J Mol Sci | Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender. | 2018 | Details |
| A12271 | 30539788 | Cell Mol Gastroenterol Hepatol | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12362 | 30484323 | Antioxid Redox Signal | Isosteviol Protects Free Fatty Acid- and High Fat Diet-Induced Hepatic Injury via Modulating PKC-β/p66Shc/ROS and Endoplasmic Reticulum Stress Pathways. | 2019 | Details |
| A12412 | 30466110 | Cell Physiol Biochem | ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data. | 2018 | Details |
| A12528 | 30409162 | Cell Commun Signal | Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway. | 2018 | Details |
| A12580 | 30379980 | Acta Biochim Biophys Sin (Shanghai) | Chronic intermittent hypoxia promotes the development of experimental non-alcoholic steatohepatitis by modulating Treg/Th17 differentiation. | 2018 | Details |
| A12679 | 30333136 | J Cell Sci | Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress. | 2018 | Details |
| A12932 | 30220454 | Cell | ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. | 2018 | Details |
| A12956 | 30209324 | Sci Rep | Systems pharmacology-based exploration reveals mechanisms of anti-steatotic effects of Jiang Zhi Granule on non-alcoholic fatty liver disease. | 2018 | Details |
| A12958 | 30208604 | Molecules | Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line. | 2018 | Details |
| A13147 | 30115876 | Molecules | Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats. | 2018 | Details |
| A13210 | 30081580 | Nutrients | Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways. | 2018 | Details |
| A13275 | 30055803 | Biochem Biophys Res Commun | Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway. | 2018 | Details |
| A13277 | 30054905 | FEBS Lett | Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. | 2018 | Details |
| A13325 | 30030460 | Sci Rep | Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD. | 2018 | Details |
| A13383 | 30008738 | PPAR Res | Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice. | 2018 | Details |
| A13387 | 30006154 | Biochim Biophys Acta Mol Basis Dis | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 2018 | Details |
| A13442 | 29971772 | J Pathol | Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. | 2018 | Details |
| A13448 | 29969718 | Free Radic Biol Med | IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. | 2018 | Details |
| A13453 | 29964161 | Pharmacol Res | Human-based systems: Mechanistic NASH modelling just around the corner? | 2018 | Details |
| A13527 | 29930001 | Arterioscler Thromb Vasc Biol | STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. | 2018 | Details |
| A13601 | 29883724 | Chem Biol Interact | Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway. | 2018 | Details |
| A13627 | 29864915 | Biomed Pharmacother | Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. | 2018 | Details |
| A13760 | 29769552 | Sci Rep | A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. | 2018 | Details |
| A13772 | 29764990 | Sci Signal | IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. | 2018 | Details |
| A13826 | 29739703 | Trends Endocrinol Metab | Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism. | 2018 | Details |
| A13827 | 29738703 | Chem Biol Interact | High fat diet induced obesity is mitigated in Cyp3a-null female mice. | 2018 | Details |
| A13877 | 29713145 | Drug Des Devel Ther | Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK-mTOR pathway. | 2018 | Details |
| A13901 | 29702089 | Chem Biol Interact | Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase. | 2018 | Details |
| A13907 | 29699606 | BMB Rep | Insulin receptor substrate 2: a bridge between Hippo and AKT pathways. | 2018 | Details |
| A13954 | 29673059 | J Cell Mol Med | The TLR4-IRE1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes. | 2018 | Details |
| A13967 | 29665983 | Trends Mol Med | IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies. | 2018 | Details |
| A13972 | 29663549 | J Gastroenterol Hepatol | Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis. | 2018 | Details |
| A14041 | 29620197 | Mol Med Rep | Identification of key genes in non‑alcoholic fatty liver disease progression based on bioinformatics analysis. | 2018 | Details |
| A14115 | 29575149 | J Cell Biochem | Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation. | 2018 | Details |
| A14198 | 29531463 | World J Gastroenterol | Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury. | 2018 | Details |
| A14250 | 29505790 | Biochem Biophys Res Commun | Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway. | 2018 | Details |
| A14295 | 29477657 | Eur J Pharmacol | Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway. | 2018 | Details |
| A14301 | 29474931 | Biochim Biophys Acta Mol Cell Biol Lipids | Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. | 2018 | Details |
| A14339 | 29457838 | Hepatology | Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. | 2018 | Details |