Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A02353 | 34406004 | J Agric Food Chem | Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis. | 2021 | Details |
| A02403 | 34385447 | Nat Commun | Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma. | 2021 | Details |
| A02434 | 34372491 | Viruses | Findings from Studies Are Congruent with Obesity Having a Viral Origin, but What about Obesity-Related NAFLD? | 2021 | Details |
| A02440 | 34371198 | Prostaglandins Other Lipid Mediat | Lipocalin-type Prostaglandin D2 Synthase appears to function as a Novel Adipokine Preventing Adipose Dysfunction in response to a High Fat Diet. | 2021 | Details |
| A02441 | 34371126 | J Nutr Biochem | Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice. | 2021 | Details |
| A02472 | 34360667 | Int J Mol Sci | Hepatic LKB1 Reduces the Progression of Non-Alcoholic Fatty Liver Disease via Genomic Androgen Receptor Signaling. | 2021 | Details |
| A02473 | 34360607 | Int J Mol Sci | Losartan Prevents Hepatic Steatosis and Macrophage Polarization by Inhibiting HIF-1α in a Murine Model of NAFLD. | 2021 | Details |
| A02475 | 34359991 | Cells | A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. | 2021 | Details |
| A02518 | 34343274 | Endocrinology | SGLT2 Inhibition for Cardiovascular Diseases, Chronic Kidney Disease, and NAFLD. | 2021 | Details |
| A02528 | 34340181 | Environ Pollut | An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis. | 2021 | Details |
| A02561 | 34328120 | Biomed Pharmacother | Molecular mechanism of DLBS3733, a bioactive fraction of Lagerstroemia speciosa (L.) Pers., on ameliorating hepatic lipid accumulation in HepG2 cells. | 2021 | Details |
| A02569 | 34326816 | Front Endocrinol (Lausanne) | New Mammalian Glycerol-3-Phosphate Phosphatase: Role in β-Cell, Liver and Adipocyte Metabolism. | 2021 | Details |
| A02582 | 34323067 | J Agric Food Chem | Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD. | 2021 | Details |
| A02603 | 34312684 | J Mol Med (Berl) | Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1. | 2021 | Details |
| A02610 | 34310978 | Gastroenterology | TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial. | 2021 | Details |
| A02682 | 34285335 | Exp Mol Med | Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue. | 2021 | Details |
| A02702 | 34278168 | Hepatol Commun | STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes. | 2021 | Details |
| A02724 | 34273192 | J Gastroenterol Hepatol | Insulin-like growth factor binding protein 1 ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease. | 2021 | Details |
| A02748 | 34261740 | Diabetes | Mutations of NRG4 Contribute to the Pathogenesis of Nonalcoholic Fatty Liver Disease and Related Metabolic Disorders. | 2021 | Details |
| A02757 | 34257694 | Evid Based Complement Alternat Med | Alleviative Effect of Ruellia tuberosa L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF-α-Treated FL83B Mouse Hepatocytes. | 2021 | Details |
| A02810 | 34233158 | Mol Cell | SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice. | 2021 | Details |
| A02819 | 34231239 | Hepatology | Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. | 2021 | Details |
| A02859 | 34214346 | J Basic Clin Physiol Pharmacol | The effects of quercetin on the expression of SREBP-1c mRNA in high-fat diet-induced NAFLD in mice. | 2021 | Details |
| A02887 | 34204987 | Antioxidants (Basel) | Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis. | 2021 | Details |
| A02888 | 34204849 | Antioxidants (Basel) | Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs' Livers. | 2021 | Details |
| A02927 | 34195217 | Front Nutr | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation. | 2021 | Details |
| A02976 | 34176536 | Nutr Res Rev | Carbohydrates deteriorate fatty liver by activating the inflammatory response. | 2021 | Details |
| A02989 | 34172319 | Nutr Metab Cardiovasc Dis | Discovery of analogues of non-β oxidizable long-chain dicarboxylic fatty acids as dual inhibitors of fatty acids and cholesterol synthesis: Efficacy of lead compound in hyperlipidemic hamsters reveals novel mechanism. | 2021 | Details |
| A03002 | 34168429 | Drug Des Devel Ther | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. | 2021 | Details |
| A03052 | 34153200 | Arch Physiol Biochem | The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets. | 2021 | Details |
| A03103 | 34130208 | Nutr Res | A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice. | 2021 | Details |
| A03112 | 34126083 | Am J Pathol | Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis. | 2021 | Details |
| A03191 | 34095107 | Front Cell Dev Biol | Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet. | 2021 | Details |
| A03245 | 34073834 | Int J Mol Sci | P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. | 2021 | Details |
| A03248 | 34072586 | Int J Mol Sci | One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver. | 2021 | Details |
| A03255 | 34069390 | Cells | Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers. | 2021 | Details |
| A03274 | 34064765 | Cells | Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death. | 2021 | Details |
| A03282 | 34062416 | Biomed Pharmacother | The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis. | 2021 | Details |
| A03287 | 34060475 | J Endocrinol | DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice. | 2021 | Details |
| A03316 | 34048566 | J Mol Cell Biol | PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway. | 2021 | Details |
| A03358 | 34029162 | Am J Physiol Endocrinol Metab | β2-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states. | 2021 | Details |
| A03364 | 34027340 | JHEP Rep | Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets. | 2021 | Details |
| A03370 | 34027265 | Hepatol Commun | Impact of Sodium Glucose Cotransporter 2 Inhibitors on Nonalcoholic Fatty Liver Disease Complicated by Diabetes Mellitus. | 2021 | Details |
| A03394 | 34017254 | Front Pharmacol | Geniposide and Chlorogenic Acid Combination Improves Non-Alcoholic Fatty Liver Disease Involving the Potent Suppression of Elevated Hepatic SCD-1. | 2021 | Details |
| A03403 | 34014450 | Hepatol Int | Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice. | 2021 | Details |
| A03442 | 33998431 | J Dev Orig Health Dis | Pregnancy and lactation after Roux-en-Y gastric bypass worsen nonalcoholic fatty liver disease in obese rats and lead to differential programming of hepatic de novo lipogenesis in offspring. | 2021 | Details |
| A03453 | 33994854 | Int J Biol Sci | Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver. | 2021 | Details |
| A03463 | 33992352 | Food Res Int | Caffeic acid prevents non-alcoholic fatty liver disease induced by a high-fat diet through gut microbiota modulation in mice. | 2021 | Details |
| A03471 | 33991450 | Physiol Rep | Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice. | 2021 | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | 2021 | Details |
| A03476 | 33989817 | Cell Mol Gastroenterol Hepatol | Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced Gene. | 2021 | Details |
| A03479 | 33989346 | PLoS One | Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? | 2021 | Details |
| A03535 | 33965533 | J Nutr Biochem | Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. | 2021 | Details |
| A03548 | 33961538 | Nanotoxicology | Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload. | 2021 | Details |
| A03588 | 33940220 | Ann Hepatol | Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice. | 2021 | Details |
| A03605 | 33934381 | Hepatology | Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. | 2021 | Details |
| A03614 | 33930596 | Mol Metab | Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease. | 2021 | Details |
| A03616 | 33930463 | J Biol Chem | NF-κB p65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet. | 2021 | Details |
| A03618 | 33928675 | Hepatology | Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes. | 2021 | Details |
| A03622 | 33926132 | Metabolites | Dietary Macronutrient Composition Differentially Modulates the Remodeling of Mitochondrial Oxidative Metabolism during NAFLD. | 2021 | Details |
| A03633 | 33923817 | Int J Mol Sci | Role of Insulin Resistance in MAFLD. | 2021 | Details |
| A03635 | 33923525 | Nutrients | The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights. | 2021 | Details |
| A03643 | 33922045 | Molecules | Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway. | 2021 | Details |
| A03651 | 33919415 | Antioxidants (Basel) | Lyophilized Maqui (Aristotelia chilensis) Berry Administration Suppresses High-Fat Diet-Induced Liver Lipogenesis through the Induction of the Nuclear Corepressor SMILE. | 2021 | Details |
| A03665 | 33915261 | J Nutr Biochem | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. | 2021 | Details |
| A03671 | 33912056 | Front Pharmacol | P- Hydroxybenzyl Alcohol Alleviates Oxidative Stress in a Nonalcoholic Fatty Liver Disease Larval Zebrafish Model and a BRL-3A Hepatocyte Via the Nrf2 Pathway. | 2021 | Details |
| A03693 | 33900847 | Am J Physiol Endocrinol Metab | High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. | 2021 | Details |
| A03715 | 33894178 | Am J Pathol | Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis. | 2021 | Details |
| A03719 | 33894019 | Hepatology | Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD. | 2021 | Details |
| A03722 | 33892169 | Mol Metab | Metabolic-associated fatty liver disease and lipoprotein metabolism. | 2021 | Details |
| A03725 | 33891332 | FASEB J | Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease. | 2021 | Details |
| A03754 | 33877249 | Food Funct | Pterostilbene modifies triglyceride metabolism in hepatic steatosis induced by high-fat high-fructose feeding: a comparison with its analog resveratrol. | 2021 | Details |
| A03758 | 33872860 | Mol Metab | Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload. | 2021 | Details |
| A03793 | 33862107 | Life Sci | Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms. | 2021 | Details |
| A03910 | 33822497 | Int J Med Mushrooms | Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review). | 2021 | Details |
| A03914 | 33820884 | Gut Liver | Effects of Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels. | 2021 | Details |
| A03918 | 33818349 | Nutr Res Rev | Effects of betaine on non-alcoholic liver disease. | 2021 | Details |
| A03925 | 33815675 | World J Hepatol | Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression. | 2021 | Details |
| A03966 | 33806955 | Biomedicines | Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04011 | 33789906 | Sci Adv | Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders. | 2021 | Details |
| A04013 | 33788613 | Environ Health Perspect | Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis. | 2021 | Details |
| A04025 | 33785339 | Life Sci | A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH. | 2021 | Details |
| A04064 | 33772116 | Commun Biol | INPP4B protects from metabolic syndrome and associated disorders. | 2021 | Details |
| A04073 | 33769609 | FASEB J | CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis. | 2021 | Details |
| A04141 | 33743554 | Hepatology | Increased Adipose Tissue Fibrogenesis, Not Impaired Expandability, Is Associated With Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04189 | 33722690 | Mol Metab | Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. | 2021 | Details |
| A04203 | 33716447 | World J Gastroenterol | G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. | 2021 | Details |
| A04205 | 33715205 | Clin Endocrinol (Oxf) | Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. | 2021 | Details |
| A04230 | 33705952 | J Nutr Biochem | n-3 PUFAs protect against adiposity and fatty liver by promoting browning in postnatally overfed male rats: a role for NRG4. | 2021 | Details |
| A04231 | 33705945 | J Nutr Biochem | High sucrose diet-induced dysbiosis of gut microbiota promotes fatty liver and hyperlipidemia in rats. | 2021 | Details |
| A04267 | 33684566 | Biochim Biophys Acta Mol Cell Biol Lipids | GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling. | 2021 | Details |
| A04269 | 33681678 | Hepatol Commun | High-Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease. | 2020 | Details |
| A04279 | 33679386 | Front Pharmacol | Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice. | 2021 | Details |
| A04293 | 33674694 | Sci Rep | DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice. | 2021 | Details |
| A04308 | 33671486 | Molecules | Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis. | 2021 | Details |
| A04317 | 33667726 | Mol Metab | Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction. | 2021 | Details |
| A04325 | 33665203 | Front Nutr | The Impact of Macronutrient Intake on Non-alcoholic Fatty Liver Disease (NAFLD): Too Much Fat, Too Much Carbohydrate, or Just Too Many Calories? | 2021 | Details |
| A04341 | 33658436 | Mol Cells | Increased Hepatic Lipogenesis Elevates Liver Cholesterol Content. | 2021 | Details |
| A04345 | 33656663 | Hepatol Int | Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease. | 2021 | Details |