Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A50740 | 35282837 | Lipids Health Dis | Fat mass and obesity-associated protein promotes liver steatosis by targeting PPARα. | 2022 | Details |
| A50778 | 35269812 | Int J Mol Sci | Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50780 | 35269515 | Cells | Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery. | 2022 | Details |
| A50792 | 35264693 | Sci Rep | Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro. | 2022 | Details |
| A50924 | 35296120 | Front Toxicol | Diet as an Exposure Source and Mediator of Per- and Polyfluoroalkyl Substance (PFAS) Toxicity. | 2020 | Details |
| A50934 | 35518778 | RSC Adv | Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice. | 2020 | Details |
| A50957 | 35520738 | RSC Adv | GVS-12 attenuates non-alcoholic steatohepatitis by suppressing inflammatory responses via PPARγ/STAT3 signaling pathways. | 2019 | Details |
| A51064 | 17407722 | Zhonghua Gan Zang Bing Za Zhi | [A study of the association between PPARr2 gene Pro12Ala polymorphism and NAFLD]. | 2007 | Details |
| A51086 | 949867 | Clin Exp Immunol | Lymphocyte transformation test with liver-specific protein and phytohaemagglutinin in patients with liver disease. | 1976 | Details |
| A51148 | 35470867 | J Food Biochem | Dietary sinapic acid attenuated high-fat diet-induced lipid metabolism and oxidative stress in male Syrian hamsters. | 2022 | Details |
| A51149 | 35469640 | J Dairy Sci | Role of sortilin 1 (SORT1) on lipid metabolism in bovine liver. | 2022 | Details |
| A51152 | 35460276 | Hepatology | Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. | 2022 | Details |
| A51177 | 35355504 | Neuropsychiatr Dis Treat | Early Lipid Metabolic Effects of the Anti-Psychotic Drug Olanzapine on Weight Gain and the Associated Gene Expression. | 2022 | Details |
| A51248 | 35464439 | Front Immunol | D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease. | 2022 | Details |
| A51280 | 7438654 | Clin Pharmacokinet | Frusemide pharmacokinetics in patients with liver disease. | 1981 | Details |
| A51282 | 87483 | J Lipid Res | Effects of ethanol on lipid metabolism. | 1979 | Details |
| A51286 | 74724 | Lancet | Cholestasis in acute alcoholic liver disease. | 1978 | Details |
| A51290 | 1080359 | Am J Med | Inhibitors of leukocyte chemotaxis in alcoholic liver disease. | 1975 | Details |
| A51299 | 35810782 | Metabolism | Comprehensive molecular mechanisms and clinical therapy in nonalcoholic steatohepatitis: An overview and current perspectives. | 2022 | Details |
| A51306 | 35735253 | Hepatol Commun | Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis. | 2022 | Details |
| A51316 | 35675500 | Clin Transl Sci | Assessment of drug-drug interaction potential with EDP-305, a farnesoid X receptor agonist, in healthy subjects. | 2022 | Details |
| A51317 | 35674880 | Clin Pharmacokinet | Effects of Hepatic Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide. | 2022 | Details |
| A51322 | 35625520 | Biology (Basel) | PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH). | 2022 | Details |
| A51334 | 35535112 | J Clin Exp Hepatol | Spectrum of Neuroimaging Abnormalities in Brain in Patients of Acute-on-Chronic Liver Failure. | 2021 | Details |
| A51359 | 35308208 | Front Pharmacol | Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. | 2022 | Details |
| A51395 | 35830259 | FASEB J | Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH. | 2022 | Details |
| A51403 | 35780059 | J Clin Lipidol | Partial lipodystrophy, severe dyslipidaemia and insulin resistant diabetes as early signs of Werner syndrome. | 2022 | Details |
| A51462 | 33989565 | Cell Chem Biol | Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. | 2021 | Details |
| A51544 | 35394122 | Pediatr Obes | Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity. | 2022 | Details |
| A51583 | 34869329 | Front Cell Dev Biol | Combined Analysis of Expression Profiles in a Mouse Model and Patients Identified BHMT2 as a New Regulator of Lipid Metabolism in Metabolic-Associated Fatty Liver Disease. | 2021 | Details |
| A51630 | 35483558 | Biochim Biophys Acta Mol Cell Biol Lipids | The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells. | 2022 | Details |
| A51635 | 35466588 | Pharmacol Res Perspect | Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways. | 2022 | Details |
| A51647 | 35291709 | Spartan Med Res J | Is Fat Deposition of Renal Sinus a Concomitant Finding to Fatty Liver Disease? The First Study Regarding the Relationship Between Kidney and Liver Fat Content with Non-Contrast Computed Tomography. | 2022 | Details |
| A51657 | 35203398 | Cells | Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation. | 2022 | Details |
| A51659 | 35187139 | Front Vet Sci | Differentiation of Subclinical Ketosis and Liver Function Test Indices in Adipose Tissues Associated With Hyperketonemia in Postpartum Dairy Cattle. | 2022 | Details |
| A51754 | 34361064 | Int J Mol Sci | PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases. | 2021 | Details |
| A51813 | 33947390 | Cardiovasc Diabetol | Effects of pemafibrate on glucose metabolism markers and liver function tests in patients with hypertriglyceridemia: a pooled analysis of six phase 2 and phase 3 randomized double-blind placebo-controlled clinical trials. | 2021 | Details |
| A51827 | 33894105 | Liver Int | Maternal nicotine exposure aggravates metabolic associated fatty liver disease via PI3K/Akt signaling in adult offspring mice. | 2021 | Details |
| A51837 | 33809061 | Cells | Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge. | 2021 | Details |
| A51911 | 33296241 | Environ Health Perspect | In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters. | 2020 | Details |
| A51923 | 33221593 | Environ Int | Systems toxicogenomics of prenatal low-dose BPA exposure on liver metabolic pathways, gut microbiota, and metabolic health in mice. | 2020 | Details |
| A51924 | 33189279 | J Dairy Sci | Differential gene expression in dairy cows under negative energy balance and ketosis: A systematic review and meta-analysis. | 2020 | Details |
| A51928 | 33168096 | Hum Genomics | Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder. | 2020 | Details |
| A51935 | 33083279 | Liver Cancer | Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. | 2020 | Details |
| A51951 | 32968453 | Oncol Lett | Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. | 2020 | Details |
| A51955 | 32917715 | Sci Adv | Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis. | 2020 | Details |
| A51969 | 32811819 | Nat Commun | Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. | 2020 | Details |
| A52037 | 32039990 | Curr Opin Lipidol | Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease. | 2020 | Details |
| A52043 | 31944172 | Autophagy | Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. | 2020 | Details |
| A52063 | 31717391 | Animals (Basel) | Effects of Dietary Apple Polyphenols Supplementation on Hepatic Fat Deposition and Antioxidant Capacity in Finishing Pigs. | 2019 | Details |
| A52064 | 31706843 | Biochem Pharmacol | Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity. | 2019 | Details |
| A52071 | 31676441 | Biochim Biophys Acta Mol Cell Biol Lipids | PPARA/RXRA signalling regulates the fate of hepatic non-esterified fatty acids in a sheep model of maternal undernutrition. | 2019 | Details |
| A52072 | 31672551 | Biochim Biophys Acta Mol Basis Dis | Fasting reveals largely intact systemic lipid mobilization mechanisms in respiratory chain complex III deficient mice. | 2019 | Details |
| A52077 | 31601915 | Sci Rep | Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice. | 2019 | Details |
| A52089 | 31429167 | Cancer Sci | Apatinib induces 3-hydroxybutyric acid production in the liver of mice by peroxisome proliferator-activated receptor α activation to aid its antitumor effect. | 2019 | Details |
| A52095 | 31308847 | PPAR Res | Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats. | 2019 | Details |
| A52096 | 31307210 | FASEB J | Ileal interposition surgery targets the hepatic TGF-β pathway, influencing gluconeogenesis and mitochondrial bioenergetics in the UCD-T2DM rat model of diabetes. | 2019 | Details |
| A52101 | 31243135 | J Virol | Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections. | 2019 | Details |
| A52102 | 31215667 | Ann N Y Acad Sci | The pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia. | 2019 | Details |
| A52131 | 30920846 | Am J Physiol Gastrointest Liver Physiol | Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. | 2019 | Details |
| A52135 | 30858281 | EMBO J | Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. | 2019 | Details |
| A52146 | 30689902 | J Clin Endocrinol Metab | Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. | 2019 | Details |
| A52147 | 30684909 | Res Vet Sci | Protein and gene expression of relevant enzymes and nuclear receptor of hepatic lipid metabolism in grazing dairy cattle during the transition period. | 2019 | Details |
| A52166 | 30481177 | PLoS One | A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone. | 2018 | Details |
| A52171 | 30463291 | Nutrients | Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice. | 2018 | Details |
| A52172 | 30429322 | Proc Natl Acad Sci U S A | Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. | 2018 | Details |
| A52176 | 30396212 | Exp Clin Endocrinol Diabetes | Impact of Brain Fatty Acid Signaling on Peripheral Insulin Action in Mice. | 2018 | Details |
| A52177 | 30381013 | Vet Pathol | Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice. | 2018 | Details |
| A52206 | 30131158 | Food Res Int | Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet. | 2018 | Details |
| A52212 | 30060615 | Mar Drugs | Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats. | 2018 | Details |
| A52215 | 30032428 | Diabetologia | A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes. | 2018 | Details |
| A52240 | 29790245 | Diabetes Obes Metab | P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates. | 2018 | Details |
| A52244 | 29751049 | Toxicol Appl Pharmacol | Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness. | 2018 | Details |
| A52252 | 29681858 | Front Pharmacol | Aqueous Extract of Black Maca Prevents Metabolism Disorder via Regulating the Glycolysis/Gluconeogenesis-TCA Cycle and PPARα Signaling Activation in Golden Hamsters Fed a High-Fat, High-Fructose Diet. | 2018 | Details |
| A52257 | 29641977 | Toxicol Appl Pharmacol | Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. | 2018 | Details |
| A52264 | 29502000 | Environ Pollut | Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway. | 2018 | Details |
| A52266 | 29484800 | Aging Cell | Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. | 2018 | Details |
| A52269 | 29453696 | Heart Fail Rev | Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance. | 2018 | Details |
| A52272 | 29419749 | Int J Mol Sci | Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr-/- Mice. | 2018 | Details |
| A52287 | 29115530 | Mol Med Rep | Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats. | 2017 | Details |
| A52296 | 28986283 | Biochim Biophys Acta Mol Cell Biol Lipids | Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. | 2017 | Details |
| A52303 | 28888048 | J Cell Physiol | Involvement of nutrients and nutritional mediators in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression. | 2017 | Details |
| A52314 | 28759385 | Lancet Oncol | Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. | 2017 | Details |
| A52325 | 28558013 | PLoS Genet | Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia. | 2017 | Details |
| A52327 | 28545035 | Oncotarget | Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. | 2017 | Details |
| A52359 | 28213130 | Biochem Biophys Res Commun | Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes. | 2017 | Details |
| A52364 | 28167956 | PPAR Res | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers. | 2017 | Details |
| A52376 | 27925195 | J Cell Physiol | Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation. | 2017 | Details |
| A52382 | 27852124 | Am J Chin Med | Metabolic Profiling of Liver Tissue in Diabetic Mice Treated with Artemisia Capillaris and Alisma Rhizome Using LC-MS and CE-MS. | 2016 | Details |
| A52387 | 27799461 | J Endocrinol | Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice. | 2016 | Details |
| A52390 | 27773823 | Biochem Biophys Res Commun | Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. | 2016 | Details |
| A52400 | 27628219 | Biol Reprod | Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice. | 2016 | Details |
| A52432 | 27185751 | Hypertension | Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. | 2016 | Details |
| A52466 | 26742069 | Nutrients | Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. | 2016 | Details |
| A52499 | 26336158 | J Mol Endocrinol | Truncation of POC1A associated with short stature and extreme insulin resistance. | 2015 | Details |
| A52509 | 26244977 | PLoS One | Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice. | 2015 | Details |
| A52533 | 25906681 | Biochim Biophys Acta | Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice. | 2015 | Details |
| A52538 | 25854303 | Endocrine | Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. | 2015 | Details |
| A52555 | 25645248 | Obesity (Silver Spring) | Interleukin-32β ameliorates metabolic disorder and liver damage in mice fed high-fat diet. | 2015 | Details |
| A52562 | 25593453 | World J Gastroenterol | Telomere shortening as genetic risk factor of liver cirrhosis. | 2015 | Details |