Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A17107 | 27988872 | Drugs | Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer's Disease. | 2017 | Details |
| A17108 | 27988847 | Eur J Nutr | Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms. | 2016 | Details |
| A17110 | 27986627 | Eur J Pharmacol | A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models. | 2016 | Details |
| A17120 | 27981809 | Mol Nutr Food Res | Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. | 2017 | Details |
| A17128 | 27976696 | Sci Rep | Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect. | 2016 | Details |
| A17141 | 27965104 | Genomics Proteomics Bioinformatics | Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data. | 2016 | Details |
| A17144 | 27959408 | Mol Med Rep | Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease. | 2016 | Details |
| A17146 | 27957651 | Metab Brain Dis | Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats. | 2016 | Details |
| A17147 | 27957247 | World J Hepatol | Bibliometric analysis of top 100 cited articles in nonalcoholic fatty liver disease research. | 2016 | Details |
| A17164 | 27938560 | Zhonghua Gan Zang Bing Za Zhi | [Effect of targeted inhibition of hypoxia-inducible factor-1α by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole on the progression of non-alcoholic fatty liver disease in rats]. | 2016 | Details |
| A17202 | 27916647 | Biochimie | PPARs and nonalcoholic fatty liver disease. | 2016 | Details |
| A17215 | 27909723 | Mol Med Rep | Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease. | 2016 | Details |
| A17216 | 27908750 | Transl Res | Mesenchymal stromal cell-based therapies reduce obesity and metabolic syndromes induced by a high-fat diet. | 2016 | Details |
| A17246 | 27890642 | Free Radic Biol Med | Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. | 2016 | Details |
| A17251 | 27889747 | Cell Physiol Biochem | Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. | 2016 | Details |
| A17269 | 27876064 | Lipids Health Dis | Melatonin improves non-alcoholic fatty liver disease via MAPK-JNK/P38 signaling in high-fat-diet-induced obese mice. | 2016 | Details |
| A17276 | 27869139 | Sci Rep | The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. | 2016 | Details |
| A17278 | 27866836 | Cell Metab | Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. | 2016 | Details |
| A17283 | 27863204 | Appl Physiol Nutr Metab | TNF and IL-18 cytokines may regulate liver fat storage under homeostasis conditions. | 2016 | Details |
| A17286 | 27862769 | Cancer Sci | NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. | 2017 | Details |
| A17297 | 27859493 | Clin Exp Pharmacol Physiol | Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. | 2017 | Details |
| A17310 | 27855315 | J Nutr Biochem | Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high-fat-diet-induced obese mice. | 2016 | Details |
| A17311 | 27853276 | Sci Rep | SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease. | 2016 | Details |
| A17321 | 27847552 | Oxid Med Cell Longev | Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17336 | 27836672 | Biochem Pharmacol | Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis. | 2016 | Details |
| A17362 | 27824080 | Sci Rep | Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. | 2016 | Details |
| A17372 | 27821715 | Physiol Rep | A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. | 2016 | Details |
| A17374 | 27818933 | Mol Metab | Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice. | 2016 | Details |
| A17382 | 27813192 | Clin Exp Pharmacol Physiol | Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. | 2017 | Details |
| A17390 | 27504850 | J Clin Endocrinol Metab | Retinol-Binding Protein 4 Induces Hepatic Mitochondrial Dysfunction and Promotes Hepatic Steatosis. | 2016 | Details |
| A17394 | 27780972 | Nat Rev Gastroenterol Hepatol | Developmental origins of NAFLD: a womb with a clue. | 2016 | Details |
| A17395 | 27729660 | Nat Rev Gastroenterol Hepatol | NAFLD and diabetes mellitus. | 2016 | Details |
| A17419 | 27794174 | Mol Nutr Food Res | Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats. | 2016 | Details |
| A17423 | 27788733 | Zhonghua Gan Zang Bing Za Zhi | [Fine particulate matter and nonalcoholic fatty liver disease]. | 2016 | Details |
| A17425 | 27788715 | Zhonghua Gan Zang Bing Za Zhi | [Autophagy and nonalcoholic fatty liver disease]. | 2016 | Details |
| A17426 | 27788713 | Zhonghua Gan Zang Bing Za Zhi | [Cholesterol metabolism and non-alcoholic steatohepatitis]. | 2016 | Details |
| A17431 | 27769711 | Chem Biol Interact | Esculetin prevents non-alcoholic fatty liver in diabetic mice fed high-fat diet. | 2016 | Details |
| A17432 | 27710160 | Metab Syndr Relat Disord | Treatment of Nonalcoholic Fatty Liver Disease with Long-Chain n-3 Polyunsaturated Fatty Acids in Humans. | 2016 | Details |
| A17438 | 27396601 | Curr Pharm Des | Lipids, Statins and Heart Failure: An Update. | 2016 | Details |
| A17447 | 27193023 | Hepatol Int | Elevated hepatic lipid and interferon stimulated gene expression in HCV GT3 patients relative to non-alcoholic steatohepatitis. | 2016 | Details |
| A17471 | 27773935 | Acta Pharmacol Sin | Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. | 2016 | Details |
| A17474 | 27732911 | J Nutr Biochem | Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. | 2016 | Details |
| A17476 | 27693777 | Toxicol Lett | Myclobutanil worsens nonalcoholic fatty liver disease: An in vitro study of toxicity and apoptosis on HepG2 cells. | 2016 | Details |
| A17485 | 27639843 | J Hepatol | Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. | 2016 | Details |
| A17488 | 27768909 | J Nutr Biochem | High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. | 2016 | Details |
| A17491 | 27765690 | Gastroenterology | Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes. | 2016 | Details |
| A17492 | 27765368 | Phytomedicine | The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. | 2016 | Details |
| A17494 | 27724997 | Br J Nutr | Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats. | 2016 | Details |
| A17497 | 27637015 | Hepatology | Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice. | 2016 | Details |
| A17512 | 27762456 | Phytother Res | Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model. | 2016 | Details |
| A17515 | 27761360 | FEBS Open Bio | Ezetimibe reduced hepatic steatosis induced by dietary oxysterols in nonhuman primates. | 2016 | Details |
| A17518 | 27760195 | PLoS One | Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. | 2016 | Details |
| A17520 | 27759439 | Expert Opin Drug Metab Toxicol | Drug-induced steatohepatitis. | 2016 | Details |
| A17524 | 27757845 | Protein Cell | Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease. | 2016 | Details |
| A17527 | 27738106 | J Biol Chem | Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17529 | 27658958 | J Mol Endocrinol | ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis. | 2016 | Details |
| A17530 | 27639112 | Redox Biol | Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. | 2016 | Details |
| A17557 | 27749006 | Mol Nutr Food Res | An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat "Western-type" diet in mice. | 2016 | Details |
| A17586 | 27732787 | Annu Rev Med | Nonalcoholic Steatohepatitis. | 2016 | Details |
| A17601 | 27723468 | J Nutr Biochem | Soy isoflavones (Glycine max) ameliorate hypertriglyceridemia and hepatic steatosis in high fat-fed ovariectomized Wistar rats (an experimental model of postmenopausal obesity). | 2016 | Details |
| A17607 | 27720799 | Life Sci | Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis. | 2016 | Details |
| A17617 | 27713108 | Environ Health Perspect | Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. | 2016 | Details |
| A17625 | 27709009 | Acta Pharm Sin B | Fatty liver diseases, bile acids, and FXR. | 2016 | Details |
| A17635 | 27697525 | Biochem Biophys Res Commun | Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats. | 2016 | Details |
| A17640 | 27694529 | Physiol Rep | Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice. | 2016 | Details |
| A17641 | 27693527 | Life Sci | Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. | 2016 | Details |
| A17645 | 27692168 | Med Hypotheses | Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor? | 2016 | Details |
| A17651 | 27688653 | World J Gastroenterol | Iron and non-alcoholic fatty liver disease. | 2016 | Details |
| A17657 | 29244927 | Patol Fiziol Eksp Ter | The impact of adipogenic diet on rats' tissue trace elements content. | 2018 | Details |
| A17662 | 27680310 | Biochem Biophys Res Commun | Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. | 2016 | Details |
| A17663 | 27679530 | J Biol Chem | Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. | 2016 | Details |
| A17676 | 27669236 | Int J Mol Sci | miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17680 | 27663419 | J Hepatol | Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. | 2016 | Details |
| A17682 | 27660157 | Probiotics Antimicrob Proteins | Probiotics Supplemented with Omega-3 Fatty Acids are More Effective for Hepatic Steatosis Reduction in an Animal Model of Obesity. | 2017 | Details |
| A17683 | 27660122 | Diabetes Care | Fatty Liver and Chronic Kidney Disease: Novel Mechanistic Insights and Therapeutic Opportunities. | 2016 | Details |
| A17705 | 27642594 | Biomed Res Int | Lipid Regulation Effects of Raw and Processed Notoginseng Radix Et Rhizome on Steatotic Hepatocyte L02 Cell. | 2016 | Details |
| A17730 | 27633111 | Adv Nutr | Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms. | 2016 | Details |
| A17731 | 27632923 | Nutr Res | Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. | 2016 | Details |
| A17733 | 27632189 | PLoS Comput Biol | A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD. | 2016 | Details |
| A17735 | 27631137 | Diabetologia | The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. | 2016 | Details |
| A17736 | 27629750 | J Transl Med | Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease. | 2016 | Details |
| A17737 | 27628945 | J Dig Dis | MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease. | 2016 | Details |
| A17742 | 27626926 | Cell Physiol Biochem | Differential Lipotoxic Effects of Palmitate and Oleate in Activated Human Hepatic Stellate Cells and Epithelial Hepatoma Cells. | 2016 | Details |
| A17758 | 27616599 | Sci Rep | Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population. | 2016 | Details |
| A17764 | 27613825 | Physiol Rep | Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice. | 2016 | Details |
| A17768 | 27610012 | World J Gastroenterol | Metabolic aspects of adult patients with nonalcoholic fatty liver disease. | 2016 | Details |
| A17771 | 27609031 | Exp Mol Med | MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. | 2016 | Details |
| A17779 | 27600823 | Am J Physiol Endocrinol Metab | Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis. | 2016 | Details |
| A17786 | 27594563 | Postepy Hig Med Dosw (Online) | New peptides players in metabolic disorders. | 2016 | Details |
| A17789 | 27592832 | Yakugaku Zasshi | Influence of High-fat and High-cholesterol Diet on Major CYP Activities in the Liver. | 2016 | Details |
| A17803 | 27576208 | Surg Obes Relat Dis | PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery. | 2016 | Details |
| A17825 | 27554471 | Diabetes | Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1. | 2016 | Details |
| A17843 | 27542533 | Reprod Toxicol | Increased susceptibility of prenatal food restricted offspring to high-fat diet-induced nonalcoholic fatty liver disease is intrauterine programmed. | 2016 | Details |
| A17866 | 27514483 | Am J Physiol Gastrointest Liver Physiol | Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice. | 2016 | Details |
| A17877 | 27506745 | Metabolism | Lipid phenotypes in patients with nonalcoholic fatty liver disease. | 2016 | Details |
| A17889 | 27494683 | Int Immunopharmacol | High-fat diet plus carbon tetrachloride-induced liver fibrosis is alleviated by betaine treatment in rats. | 2016 | Details |
| A17901 | 27487733 | Food Funct | Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. | 2016 | Details |
| A17905 | 27485440 | Nutr J | Role of bioactive fatty acids in nonalcoholic fatty liver disease. | 2016 | Details |
| A17908 | 27484357 | Int J Food Sci Nutr | Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection. | 2016 | Details |
| A17911 | 27483220 | Molecules | Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice. | 2016 | Details |