Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Glutathione718 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A12759 | 30298849 | J Toxicol Sci | Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. | 2018 | Details |
| A12870 | 30248445 | Free Radic Biol Med | Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male rat. | 2018 | Details |
| A12891 | 30239004 | J Cell Physiol | Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis. | 2018 | Details |
| A12930 | 30221679 | Int J Mol Med | Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice. | 2018 | Details |
| A12968 | 30202895 | Toxicol Sci | Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. | 2019 | Details |
| A12977 | 30200543 | Nutrients | Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats. | 2018 | Details |
| A13067 | 30154382 | Int J Mol Sci | Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells. | 2018 | Details |
| A13069 | 30153476 | Free Radic Biol Med | Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. | 2018 | Details |
| A13090 | 30142454 | Free Radic Biol Med | Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. | 2018 | Details |
| A13264 | 32186078 | J Tradit Chin Med | Effects of extracts from soothing-liver and invigorating-spleen formulas on the injury induced by oxidative stress in the hepatocytes of rats with non-alcoholic fatty liver disease induced by high-fat diet. | 2018 | Details |
| A13271 | 30057681 | Oxid Med Cell Longev | Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT. | 2018 | Details |
| A13344 | 30023333 | Adv Pharm Bull | Effects of Pharmacologic Dose of Resveratrol Supplementation on Oxidative/Antioxidative Status Biomarkers in Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. | 2018 | Details |
| A13358 | 30016770 | Dig Dis | Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A13381 | 30009570 | Physiol Rep | Curcumin supplementation mitigates NASH development and progression in female Wistar rats. | 2018 | Details |
| A13382 | 30009361 | Folia Morphol (Warsz) | The differential effects of high-fat and high- -fructose diets on the liver of male albino rat and the proposed underlying mechanisms. | 2018 | Details |
| A13502 | 29946793 | Amino Acids | Taurine attenuates the development of hepatic steatosis through the inhibition of oxidative stress in a model of nonalcoholic fatty liver disease in vivo and in vitro. | 2018 | Details |
| A13591 | 29890650 | Foods | Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. | 2018 | Details |
| A13598 | 29887885 | Adv Pharmacol Sci | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease's Statin Therapy in Men. | 2018 | Details |
| A13678 | 29844386 | Nat Commun | The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. | 2018 | Details |
| A13687 | 29805535 | Exp Ther Med | The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats. | 2018 | Details |
| A13705 | 29799837 | PLoS One | Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice. | 2018 | Details |
| A13750 | 29775890 | Biomed Pharmacother | Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates non-alcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction. | 2018 | Details |
| A13786 | 29758334 | J Hepatol | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. | 2018 | Details |
| A13789 | 29756964 | Nutr Hosp | Açai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. | 2018 | Details |
| A13897 | 29704577 | Food Chem Toxicol | Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids. | 2018 | Details |
| A13913 | 29697385 | Georgian Med News | INTENSITY OF THE ANTIOXIDANT PROTECTION SYSTEM AND OXIDATIVE STRESS FACTORS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS DEPENDING ON THE FORM OF CHRONIC KIDNEY DISEASE. | 2018 | Details |
| A13988 | 29655752 | Food Chem | Systematic evaluation of phenolic compounds and protective capacity of a new mulberry cultivar J33 against palmitic acid-induced lipotoxicity using a simulated digestion method. | 2018 | Details |
| A14038 | 29622764 | Exp Mol Med | Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. | 2018 | Details |
| A14134 | 29569850 | CPT Pharmacometrics Syst Pharmacol | Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14185 | 29545896 | Exp Ther Med | Influence of different concentrations of uric acid on oxidative stress in steatosis hepatocytes. | 2018 | Details |
| A14236 | 29511669 | Biomed Res Int | Ethanol Extract from Ulva prolifera Prevents High-Fat Diet-Induced Insulin Resistance, Oxidative Stress, and Inflammation Response in Mice. | 2018 | Details |
| A14259 | 29499310 | Neurosci Lett | Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1-42 (Aβ1-42) induced neurotoxicity in PC12 cells. | 2018 | Details |
| A14455 | 29402900 | Sci Rep | Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH. | 2018 | Details |
| A14461 | 29400110 | Free Radic Res | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Details |
| A14504 | 29378152 | Can J Physiol Pharmacol | Beneficial effects of N-acetylcysteine on hepatic oxidative stress in streptozotocin-induced diabetic rats. | 2018 | Details |
| A14567 | 29350757 | J Food Sci | Hepatoprotective Effects of Sophoricoside against Fructose-Induced Liver Injury via Regulating Lipid Metabolism, Oxidation, and Inflammation in Mice. | 2018 | Details |
| A14649 | 29309075 | Food Funct | Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. | 2018 | Details |
| A14764 | 29249184 | Hum Exp Toxicol | Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention. | 2017 | Details |
| A14920 | 29174039 | Biomed Pharmacother | Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. | 2017 | Details |
| A14940 | 29164820 | Liver Int | Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models. | 2017 | Details |
| A14948 | 29160087 | Antioxid Redox Signal | Glyoxalase 1 Modulation in Obesity and Diabetes. | 2018 | Details |
| A14950 | 29159325 | Hepatol Commun | Role of Aramchol in steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14953 | 29158183 | Biochim Biophys Acta Mol Basis Dis | Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes. | 2017 | Details |
| A15000 | 29129237 | Nutrition | Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. | 2017 | Details |
| A15147 | 29074597 | Diabetes | S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy. | 2017 | Details |
| A15157 | 29069580 | Eur J Pharmacol | Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress. | 2017 | Details |
| A15253 | 29023387 | Nutrients | Combination of β-glucan and Morus alba L. Leaf Extract Promotes Metabolic Benefits in Mice Fed a High-Fat Diet. | 2017 | Details |
| A15281 | 28988798 | Free Radic Biol Med | Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. | 2017 | Details |
| A15367 | 28942443 | Cell Physiol Biochem | A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats. | 2017 | Details |
| A15369 | 28942246 | Free Radic Biol Med | Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide. | 2017 | Details |
| A15446 | 28903486 | Toxicol Sci | Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. | 2017 | Details |
| A15524 | 28862329 | J Sci Food Agric | Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. | 2017 | Details |
| A15579 | 28834687 | Appl Physiol Nutr Metab | Weight loss enhances hepatic antioxidant status in a NAFLD model induced by high-fat diet. | 2017 | Details |
| A15628 | 28802074 | Hepatology | Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance. | 2017 | Details |
| A15649 | 28789631 | BMC Gastroenterol | Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. | 2017 | Details |
| A15655 | 28781602 | Nutr Metab (Lond) | eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. | 2017 | Details |
| A15687 | 28759733 | Can J Physiol Pharmacol | Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin. | 2017 | Details |
| A15886 | 28670854 | J Gastroenterol Hepatol | Honokiol attenuates diet-induced non-alcoholic steatohepatitis by regulating macrophage polarization through activating peroxisome proliferator-activated receptor γ. | 2018 | Details |
| A15921 | 28652427 | In Vivo | A Long-term Treatment with Silybin in Patients with Non-alcoholic Steatohepatitis Stimulates Catalase Activity in Human Endothelial Cells. | 2018 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16129 | 28549240 | J Nutr Biochem | Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats. | 2017 | Details |
| A16245 | 28486193 | Biomed Pharmacother | Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. | 2017 | Details |
| A16402 | 28416740 | Oncotarget | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease. | 2017 | Details |
| A16429 | 28395666 | Lipids Health Dis | Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. | 2017 | Details |
| A16576 | 28298424 | Sci Transl Med | Richer data with personalized GEMs. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16661 | 28257781 | Food Chem Toxicol | Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. | 2017 | Details |
| A16668 | 28254760 | Mol Syst Biol | Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. | 2017 | Details |
| A16705 | 28232481 | FASEB J | Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance. | 2017 | Details |
| A16706 | 28232454 | Am J Physiol Gastrointest Liver Physiol | A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition. | 2017 | Details |
| A16822 | 28149843 | Ann Transl Med | Gamma-glutamyl transferase and cardiovascular disease. | 2016 | Details |
| A16949 | 28077733 | J Nutr | Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens. | 2017 | Details |
| A16976 | 28067231 | Sci Rep | Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide. | 2017 | Details |
| A17049 | 28028366 | World J Gastroenterol | Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. | 2016 | Details |
| A17087 | 27998724 | Am J Pathol | Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. | 2016 | Details |
| A17123 | 27980597 | Nutr Metab (Lond) | Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis. | 2016 | Details |
| A17136 | 27973423 | Nutrients | Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet. | 2016 | Details |
| A17189 | 27920819 | Res Pharm Sci | Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver. | 2016 | Details |
| A17233 | 27896396 | Anal Bioanal Chem | Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway. | 2016 | Details |
| A17486 | 27634173 | Free Radic Biol Med | Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A17512 | 27762456 | Phytother Res | Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model. | 2016 | Details |
| A17639 | 27695900 | Diabetologia | An oxidative stress paradox: time for a conceptual change? | 2016 | Details |
| A17678 | 27666673 | J Periodontol | Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats. | 2016 | Details |
| A17687 | 27658772 | Gastroenterology | Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. | 2016 | Details |
| A17731 | 27632923 | Nutr Res | Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. | 2016 | Details |
| A17739 | 27628106 | Diabetologia | Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice. | 2016 | Details |
| A17777 | 27603810 | Minerva Gastroenterol Dietol | Glutathione in the treatment of liver diseases: insights from clinical practice. | 2016 | Details |
| A17899 | 27491150 | Lik Sprava | [PATOGENETIC VALUE OF VIOLATIONS FROM GLUTATHIONE SYSTEM AT THE PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS ON A BACKGROUND OF DIABETES MELLITUS TYPE II]. | 2016 | Details |
| A17946 | 27458852 | Turk J Gastroenterol | Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease. | 2016 | Details |
| A18127 | 27338619 | Glycoconj J | Dicarbonyl stress in clinical obesity. | 2016 | Details |
| A18156 | 27315552 | Mol Med Rep | Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet. | 2016 | Details |
| A18182 | 27306319 | Int J Toxicol | Intravenous Administration of Multiwalled Carbon Nanotubes Aggravates High-Fat Diet-Induced Nonalcoholic Steatohepatitis in Sprague Dawley Rats. | 2016 | Details |
| A18235 | 27266339 | J Med Food | Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase α Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18320 | 27214602 | J Med Food | Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18337 | 27197688 | J Diabetes Complications | Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes. | 2016 | Details |
| A18384 | 27171561 | PLoS One | Liver Function Test Abnormalities in Depressed Patients Treated with Antidepressants: A Real-World Systematic Observational Study in Psychiatric Settings. | 2016 | Details |
| A18425 | 27143995 | Oxid Med Cell Longev | Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. | 2016 | Details |
| A18610 | 27036364 | Free Radic Biol Med | A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis. | 2016 | Details |
| A18638 | 27019761 | Scientifica (Cairo) | A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice. | 2016 | Details |