Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A01609 | 34680522 | Biomedicines | Lipid Disorders in NAFLD and Chronic Kidney Disease. | 2021 | Details |
| A01614 | 34679681 | Antioxidants (Basel) | Ameliorative Effect of Annona muricata (Graviola) Extract on Hyperglycemia Induced Hepatic Damage in Type 2 Diabetic Mice. | 2021 | Details |
| A01623 | 34678296 | Clin Chim Acta | The potential pathophysiological role of altered lipid metabolism and electronegative low-density lipoprotein (LDL) in non-alcoholic fatty liver disease and cardiovascular diseases. | 2021 | Details |
| A01626 | 34677372 | Metabolites | In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels. | 2021 | Details |
| A01627 | 34677008 | Hepatol Commun | Low Lipoprotein(a) Levels Predict Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01631 | 34675931 | Front Immunol | Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice. | 2021 | Details |
| A01649 | 34668765 | J Med Food | Ameliorative Effect of Myricetin on Nonalcoholic Fatty Liver Disease in ob/ob Mice. | 2021 | Details |
| A01654 | 34666041 | J Biol Chem | Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. | 2021 | Details |
| A01657 | 34665236 | J Mol Cell Biol | cGAS‒STING signaling and function in metabolism and kidney diseases. | 2021 | Details |
| A01660 | 34664288 | J Food Biochem | Sesamol ameliorates hepatic lipid accumulation and oxidative stress in steatosis HepG2 cells via the PPAR signaling pathway. | 2021 | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
| A01685 | 34654875 | Acta Pharmacol Sin | Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. | 2021 | Details |
| A01687 | 34653759 | Biomed Pharmacother | Effects of DHA dietary intervention on hepatic lipid metabolism in apolipoprotein E-deficient and C57BL/6J wild-type mice. | 2021 | Details |
| A01689 | 34653601 | J Nutr Biochem | Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways. | 2021 | Details |
| A01693 | 34652536 | Mol Cell Biochem | Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3. | 2021 | Details |
| A01706 | 34649219 | Biomed Pharmacother | Foresight regarding drug candidates acting on the succinate-GPR91 signalling pathway for non-alcoholic steatohepatitis (NASH) treatment. | 2021 | Details |
| A01721 | 34639207 | Int J Mol Sci | Flaxseed Powder Attenuates Non-Alcoholic Steatohepatitis via Modulation of Gut Microbiota and Bile Acid Metabolism through Gut-Liver Axis. | 2021 | Details |
| A01722 | 34639029 | Int J Mol Sci | Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio. | 2021 | Details |
| A01723 | 34638941 | Int J Mol Sci | MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A01728 | 34635855 | Nat Med | ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials. | 2021 | Details |
| A01731 | 34634561 | Biomed Pharmacother | Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice. | 2021 | Details |
| A01732 | 34634521 | Mol Metab | STE20-type kinase TAOK3 regulates hepatic lipid partitioning. | 2021 | Details |
| A01738 | 34631329 | Biosci Microbiota Food Health | Effects of a high-γ-polyglutamic acid-containing natto diet on liver lipids and cecal microbiota of adult female mice. | 2021 | Details |
| A01754 | 34629052 | Lipids Health Dis | Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. | 2021 | Details |
| A01756 | 34628383 | Georgian Med News | THE INFLUENCE OF HYPERCHOLESTEROLEMIA AND CONCOMITANT STATIN THERAPY ON THE STATE OF PLATELET-PLASMA HEMOSTASIS IN PATIENTS WITH ESSENTIAL HYPERTENSION AND NON-ALCOHOLIC FATTY LIVER DISEASE. | 2021 | Details |
| A01758 | 34627976 | J Hepatol | Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. | 2021 | Details |
| A01762 | 34626855 | Mol Metab | The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis. | 2021 | Details |
| A01785 | 34618982 | FASEB J | Omega-3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non-alcoholic fatty liver disease. | 2021 | Details |
| A01791 | 34616724 | Front Cell Dev Biol | Comprehensive Analysis of NAFLD and the Therapeutic Target Identified. | 2021 | Details |
| A01808 | 34607257 | Biochem Biophys Res Commun | The alleviating effect of sphingosine kinases 2 inhibitor K145 on nonalcoholic fatty liver. | 2021 | Details |
| A01810 | 34607007 | Fish Shellfish Immunol | Polysaccharide extract from pomelo fruitlet ameliorates diet-induced nonalcoholic fatty liver disease in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). | 2021 | Details |
| A01815 | 34606548 | Food Funct | Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats. | 2021 | Details |
| A01820 | 34604283 | Front Nutr | Combined Transcriptomic and Lipidomic Analysis Reveals Dysregulated Genes Expression and Lipid Metabolism Profiles in the Early Stage of Fatty Liver Disease in Rats. | 2021 | Details |
| A01833 | 34601002 | Mol Cell Endocrinol | Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK/SIRT1-mediated suppression of inflammation. | 2021 | Details |
| A01839 | 34597608 | Life Sci | The role of Sirtuin 2 in sustaining functional integrity of the liver. | 2021 | Details |
| A01844 | 34592488 | Phytomedicine | Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. | 2021 | Details |
| A01851 | 34589520 | Front Mol Biosci | Saliva and Plasma Reflect Metabolism Altered by Diabetes and Periodontitis. | 2021 | Details |
| A01870 | 34579012 | Nutrients | Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis. | 2021 | Details |
| A01872 | 34578867 | Nutrients | Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis. | 2021 | Details |
| A01875 | 34576229 | Int J Mol Sci | Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. | 2021 | Details |
| A01876 | 34576136 | Int J Mol Sci | Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice. | 2021 | Details |
| A01878 | 34576053 | Int J Mol Sci | Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism. | 2021 | Details |
| A01880 | 34575933 | Int J Mol Sci | Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line. | 2021 | Details |
| A01882 | 34574082 | Foods | AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. | 2021 | Details |
| A01884 | 34573421 | Genes (Basel) | The Mitochondrial Trigger in an Animal Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01889 | 34572415 | Biomedicines | Cisd2 Preserves the Youthful Pattern of the Liver Proteome during Natural Aging of Mice. | 2021 | Details |
| A01892 | 34571924 | Cells | Perspectives on Mitochondria-ER and Mitochondria-Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism. | 2021 | Details |
| A01893 | 34571189 | J Nutr Biochem | Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice. | 2021 | Details |
| A01906 | 34565720 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | Abnormal m6A modification in non-alcoholic fatty liver disease. | 2021 | Details |
| A01917 | 34563665 | J Nutr Biochem | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. | 2021 | Details |
| A01927 | 34560015 | Lancet Gastroenterol Hepatol | Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study. | 2021 | Details |
| A01941 | 34558644 | Mol Med Rep | PPARγ attenuates hepatic inflammation and oxidative stress of non‑alcoholic steatohepatitis via modulating the miR‑21‑5p/SFRP5 pathway. | 2021 | Details |
| A01946 | 34557398 | Pediatr Gastroenterol Hepatol Nutr | The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity. | 2021 | Details |
| A01951 | 34555423 | J Hepatol | Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function. | 2021 | Details |
| A01971 | 34547464 | Mol Ther | METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease. | 2021 | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | 2021 | Details |
| A01986 | 34540943 | Visc Med | Excess Body Weight and Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD). | 2021 | Details |
| A02007 | 34532996 | Hepatol Commun | TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease. | 2021 | Details |
| A02009 | 34532024 | Food Sci Nutr | ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase. | 2021 | Details |
| A02025 | 34528223 | Horm Metab Res | Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02055 | 34519030 | Eur J Clin Invest | Hydrogen sulphide in liver glucose/lipid metabolism and non-alcoholic fatty liver disease. | 2021 | Details |
| A02057 | 34517466 | Zhonghua Gan Zang Bing Za Zhi | [New development for targeted therapy of non-alcoholic fatty liver disease with thyroid hormone receptor beta]. | 2021 | Details |
| A02067 | 34512784 | Evid Based Complement Alternat Med | Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation. | 2021 | Details |
| A02094 | 34508810 | Pharmacol Res | GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation. | 2021 | Details |
| A02100 | 34508238 | Nat Rev Gastroenterol Hepatol | Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. | 2021 | Details |
| A02110 | 34503976 | Mol Pharmacol | Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene. | 2021 | Details |
| A02111 | 34503201 | Cancers (Basel) | Lipid Droplet-Associated Factors, PNPLA3, TM6SF2, and HSD17B Proteins in Hepatopancreatobiliary Cancer. | 2021 | Details |
| A02128 | 34496884 | Lipids Health Dis | Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis. | 2021 | Details |
| A02129 | 34496264 | J Ethnopharmacol | Mechanism by which Eucommia ulmoides leaves Regulate Nonalcoholic fatty liver disease based on system pharmacology. | 2021 | Details |
| A02144 | 34488621 | Mol Med | MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice. | 2021 | Details |
| A02148 | 34486133 | J Food Biochem | Regulatory mechanisms of energy metabolism and inflammation in oleic acid-treated HepG2 cells from Lactobacillus acidophilus NX2-6 extract. | 2021 | Details |
| A02150 | 34485686 | Mol Ther Oncolytics | Regulatory role and mechanism of m6A RNA modification in human metabolic diseases. | 2021 | Details |
| A02164 | 34478753 | Metabolism | Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk. | 2021 | Details |
| A02166 | 34478580 | FASEB J | CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level. | 2021 | Details |
| A02181 | 34471049 | Biol Pharm Bull | Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist. | 2021 | Details |
| A02214 | 34456873 | Front Endocrinol (Lausanne) | Purinergic Signaling in Liver Pathophysiology. | 2021 | Details |
| A02223 | 34454176 | Biochem Biophys Res Commun | Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis. | 2021 | Details |
| A02225 | 34453940 | Life Sci | Pancreastatin induces hepatic steatosis in type 2 diabetes by impeding mitochondrial functioning. | 2021 | Details |
| A02230 | 34453120 | Lab Invest | Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH. | 2021 | Details |
| A02233 | 34450307 | Pharmacol Res | Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis. | 2021 | Details |
| A02234 | 34450194 | Prog Lipid Res | PARPs in lipid metabolism and related diseases. | 2021 | Details |
| A02235 | 34450119 | Exp Cell Res | miR-23b Ameliorates nonalcoholic steatohepatitis by targeting Acyl-CoA thioesterases 4. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02265 | 34443333 | Molecules | Phenolics-Rich Extracts of Dietary Plants as Regulators of Fructose Uptake in Caco-2 Cells via GLUT5 Involvement. | 2021 | Details |
| A02268 | 34441028 | Medicina (Kaunas) | Phytotherapy as Multi-Hit Therapy to Confront the Multiple Pathophysiology in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Experimental Interventions. | 2021 | Details |
| A02295 | 34433228 | Hepatology | Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice. | 2021 | Details |
| A02306 | 34426744 | Evid Based Complement Alternat Med | Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver. | 2021 | Details |
| A02309 | 34426119 | Int Immunopharmacol | Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota. | 2021 | Details |
| A02323 | 34419589 | Biochim Biophys Acta Mol Cell Biol Lipids | Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes. | 2021 | Details |
| A02333 | 34414956 | Medicine (Baltimore) | Relationship between serum uric acid level and nonalcoholic fatty liver disease in type 2 diabetes patients. | 2021 | Details |
| A02340 | 34411447 | EMBO Mol Med | Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice. | 2021 | Details |
| A02342 | 34410623 | Hum Cell | Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. | 2021 | Details |
| A02355 | 34405221 | Sheng Li Xue Bao | [Arachidonic acid metabolism in liver glucose and lipid homeostasis]. | 2021 | Details |
| A02358 | 34404276 | Crit Rev Food Sci Nutr | Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut-liver axis. | 2021 | Details |
| A02365 | 34401690 | JHEP Rep | Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication. | 2021 | Details |
| A02373 | 34399601 | Int J Immunopathol Pharmacol | Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice. | 2022 | Details |
| A02374 | 34399486 | Food Res Int | Protective and ameliorating effects of probiotics against diet-induced obesity: A review. | 2021 | Details |
| A02375 | 34399465 | Food Res Int | Regulatory effects of Lactobacillus fermented black barley on intestinal microbiota of NAFLD rats. | 2021 | Details |
| A02380 | 34396890 | Arch Physiol Biochem | Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases. | 2021 | Details |
| A02383 | 34395490 | Front Nutr | Broccoli Florets Supplementation Improves Insulin Sensitivity and Alters Gut Microbiome Population-A Steatosis Mice Model Induced by High-Fat Diet. | 2021 | Details |