Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A04366 | 33647280 | Gastroenterology | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | 2021 | Details |
| A04405 | 33631228 | J Hepatol | Targeting cell-intrinsic metabolism for antifibrotic therapy. | 2021 | Details |
| A04414 | 33628193 | Front Pharmacol | Fructose and Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A04491 | 33597924 | Front Endocrinol (Lausanne) | The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A04558 | 33580458 | Mol Biol Rep | Evaluating the effect of a mixture of two main conjugated linoleic acid isomers on hepatic steatosis in HepG2 cellular model. | 2021 | Details |
| A04591 | 33571540 | Metabolism | The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling. | 2021 | Details |
| A04642 | 33554072 | iScience | Impact of liver-specific GLUT8 silencing on fructose-induced inflammation and omega oxidation. | 2021 | Details |
| A04660 | 33548473 | J Nutr Biochem | Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A04662 | 33548387 | J Hepatol | FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. | 2021 | Details |
| A04664 | 33548031 | Hepatol Int | How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease? | 2021 | Details |
| A04667 | 33546405 | Nutrients | Effects of Long-Term DHA Supplementation and Physical Exercise on Non-Alcoholic Fatty Liver Development in Obese Aged Female Mice. | 2021 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A04712 | 33531899 | Int J Endocrinol | Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A. | 2021 | Details |
| A04713 | 33531575 | Sci Rep | High-fructose feeding does not induce steatosis or non-alcoholic fatty liver disease in pigs. | 2021 | Details |
| A04741 | 33517848 | Can J Physiol Pharmacol | Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production. | 2021 | Details |
| A04759 | 33513687 | Biology (Basel) | A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. | 2021 | Details |
| A04783 | 33506572 | Liver Int | Fibroblast Growth Factor 19: Potential modulation of hepatic metabolism for the treatment of non-alcoholic fatty liver disease. | 2021 | Details |
| A04789 | 33505208 | Food Technol Biotechnol | Antioxidant Capacity of Proteins and Hydrolysates from the Liver of Newborn Piglets, and Their Inhibitory Effects on Steatosis in vitro. | 2020 | Details |
| A04831 | 33490936 | JHEP Rep | Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. | 2020 | Details |
| A04882 | 33468321 | Trends Pharmacol Sci | Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent. | 2021 | Details |
| A04884 | 33467546 | Int J Mol Sci | Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis. | 2021 | Details |
| A04888 | 33465519 | Mol Metab | Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes. | 2021 | Details |
| A04916 | 33450094 | J Physiol | Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex-specific manner. | 2021 | Details |
| A04925 | 33446707 | Sci Rep | The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis. | 2021 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A04987 | 33424396 | Saudi J Biol Sci | Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice. | 2020 | Details |
| A05027 | 33404569 | Food Funct | The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice. | 2021 | Details |
| A05028 | 33404223 | J Agric Food Chem | Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner. | 2021 | Details |
| A05029 | 33404166 | Int J Clin Pract | The association of the adipokine zinc-alpha2-glycoprotein with non-alcoholic fatty liver disease and related risk factors: A comprehensive systematic review. | 2021 | Details |
| A05060 | 33390979 | Front Pharmacol | Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate. | 2020 | Details |
| A05154 | 33352441 | Int Immunopharmacol | Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses. | 2020 | Details |
| A05177 | 33346069 | Mol Metab | Metabolic drivers of non-alcoholic fatty liver disease. | 2020 | Details |
| A05185 | 33343508 | Front Endocrinol (Lausanne) | ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue. | 2020 | Details |
| A05187 | 33343352 | Front Pharmacol | Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05192 | 33341045 | Biomed Pharmacother | β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway. | 2020 | Details |
| A05247 | 33325808 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05256 | 33321020 | Acta Gastroenterol Belg | Proteins involved in lipid metabolism as possible biomarkers or predisposing factors for non-alcoholic fatty liver disease. | 2020 | Details |
| A05261 | 33320482 | Postepy Biochem | Transcription factor ChREBP – the coordinator of carbohydrate and lipid metabolism | 2020 | Details |
| A05270 | 33318479 | Cell Death Dis | Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner. | 2020 | Details |
| A05317 | 33303988 | Acta Pharmacol Sin | 3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity. | 2020 | Details |
| A05326 | 33302316 | Horm Metab Res | Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice. | 2020 | Details |
| A05337 | 33298075 | Lipids Health Dis | Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease. | 2020 | Details |
| A05345 | 33293347 | Diabetes Care | Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05351 | 33290156 | Can J Physiol Pharmacol | Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro. | 2020 | Details |
| A05352 | 33289350 | Diabetes Obes Metab | Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. | 2020 | Details |
| A05357 | 33283879 | J Cell Physiol | Endogenous metabolite, kynurenic acid, attenuates nonalcoholic fatty liver disease via AMPK/autophagy- and AMPK/ORP150-mediated signaling. | 2020 | Details |
| A05363 | 33281780 | Front Microbiol | Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice. | 2020 | Details |
| A05380 | 33276146 | Mol Metab | Mitochondrial oxidative function in NAFLD: Friend or foe? | 2020 | Details |
| A05383 | 33275637 | PLoS One | The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A05388 | 33273997 | Oxid Med Cell Longev | Plant Sterol Ester of α-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial Biogenesis. | 2019 | Details |
| A05397 | 33271332 | Mol Metab | Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis. | 2020 | Details |
| A05399 | 33270924 | J Bone Miner Res | Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models. | 2020 | Details |
| A05426 | 33260679 | Nutrients | The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice. | 2020 | Details |
| A05427 | 33260590 | Int J Mol Sci | Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation. | 2020 | Details |
| A05441 | 33255949 | Biology (Basel) | Why Hepatic CYP2E1-Elevation by Itself Is Insufficient for Inciting NAFLD/NASH: Inferences from Two Genetic Knockout Mouse Models. | 2020 | Details |
| A05445 | 33254688 | Environ Pollut | Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes. | 2020 | Details |
| A05489 | 33235221 | Nat Commun | Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A. | 2020 | Details |
| A05492 | 33234776 | Curr Opin Lipidol | Liver fat storage pathways: methodologies and dietary effects. | 2021 | Details |
| A05496 | 33232883 | Eur J Cell Biol | Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders. | 2020 | Details |
| A05527 | 33218081 | Biology (Basel) | Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05559 | 33205999 | Am J Physiol Gastrointest Liver Physiol | GPCRs get fatty: the role of G protein-coupled receptor signaling in the development and progression of nonalcoholic fatty liver disease. | 2020 | Details |
| A05613 | 33187321 | Pharmaceuticals (Basel) | Germinated Soybean Embryo Extract Ameliorates Fatty Liver Injury in High-Fat Diet-Fed Obese Mice. | 2020 | Details |
| A05617 | 33186794 | Biomed Pharmacother | Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. | 2020 | Details |
| A05626 | 33184849 | J Cell Physiol | Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis. | 2020 | Details |
| A05664 | 33167594 | Int J Mol Sci | Histone H3K9 Demethylase JMJD2B Plays a Role in LXRα-Dependent Lipogenesis. | 2020 | Details |
| A05678 | 33163831 | Hepatol Commun | Loss of Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Links Nonalcoholic Steatohepatitis to Atherosclerosis. | 2020 | Details |
| A05685 | 33159388 | FEBS Open Bio | MiR-22 modulates the expression of lipogenesis-related genes and promotes hepatic steatosis in vitro. | 2020 | Details |
| A05713 | 33144913 | Oxid Med Cell Longev | Amelioration by Idesia polycarpa Maxim. var. vestita Diels. of Oleic Acid-Induced Nonalcoholic Fatty Liver in HepG2 Cells through Antioxidant and Modulation of Lipid Metabolism. | 2020 | Details |
| A05714 | 33144268 | Ann Anat | Can Dasatinib Ameliorate the Hepatic changes, Induced by Long Term Western Diet, in Mice? | 2020 | Details |
| A05735 | 33139661 | Int J Mol Sci | Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome. | 2020 | Details |
| A05744 | 33134908 | JHEP Rep | Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor. | 2020 | Details |
| A05748 | 33133572 | Food Sci Nutr | Alleviative effect of Ruellia tuberosa L. on NAFLD and hepatic lipid accumulation via modulating hepatic de novo lipogenesis in high-fat diet plus streptozotocin-induced diabetic rats. | 2020 | Details |
| A05764 | 33127939 | Sci Rep | Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid. | 2020 | Details |
| A05787 | 33117273 | Front Endocrinol (Lausanne) | Palmitoleic Acid Decreases Non-alcoholic Hepatic Steatosis and Increases Lipogenesis and Fatty Acid Oxidation in Adipose Tissue From Obese Mice. | 2020 | Details |
| A05804 | 33113993 | Nutrients | Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation. | 2020 | Details |
| A05808 | 33112796 | J Endocrinol | GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner. | 2021 | Details |
| A05820 | 33106141 | Curr Mol Med | Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator. | 2021 | Details |
| A05828 | 33105604 | Int J Mol Sci | Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor. | 2020 | Details |
| A05921 | 33075563 | Cell Mol Gastroenterol Hepatol | S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis. | 2020 | Details |
| A05946 | 33067533 | Sci Rep | HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse. | 2020 | Details |
| A06004 | 33040080 | Cell Death Dis | USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. | 2020 | Details |
| A06013 | 33037981 | Hepatol Int | Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism. | 2020 | Details |
| A06019 | 33037652 | J Food Sci | Coniferaldehyde ameliorates the lipid and glucose metabolism in palmitic acid-induced HepG2 cells via the LKB1/AMPK signaling pathway. | 2020 | Details |
| A06045 | 33029298 | Anim Cells Syst (Seoul) | Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice. | 2020 | Details |
| A06056 | 33026380 | Food Funct | Gut inflammation exacerbates hepatic injury in C57BL/6J mice via gut-vascular barrier dysfunction with high-fat-incorporated meat protein diets. | 2020 | Details |
| A06071 | 33017610 | J Nutr Biochem | Liver lipidome signature and metabolic pathways in nonalcoholic fatty liver disease induced by a high-sugar diet. | 2020 | Details |
| A06078 | 33014333 | Cell Biosci | Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice. | 2020 | Details |
| A06113 | 33002003 | PLoS One | REV-ERB agonism improves liver pathology in a mouse model of NASH. | 2020 | Details |
| A06127 | 32996649 | FASEB J | N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. | 2020 | Details |
| A06136 | 32992548 | Antioxidants (Basel) | Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro. | 2020 | Details |
| A06222 | 32963289 | Sci Rep | Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. | 2020 | Details |
| A06223 | 32963259 | Sci Rep | Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis. | 2020 | Details |
| A06225 | 32962167 | Mar Drugs | Diphlorethohydroxycarmalol Attenuates Palmitate-Induced Hepatic Lipogenesis and Inflammation. | 2020 | Details |
| A06284 | 32942044 | Cell Mol Gastroenterol Hepatol | Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. | 2020 | Details |
| A06320 | 32930541 | Eur J Histochem | β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet. | 2020 | Details |
| A06348 | 32920226 | Redox Biol | Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis. | 2020 | Details |
| A06354 | 32918763 | FASEB J | Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD. | 2020 | Details |
| A06365 | 32914125 | Curr Res Food Sci | Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells. | 2020 | Details |
| A06387 | 32899418 | Biomolecules | Hepatic Lipidomics and Molecular Imaging in a Murine Non-Alcoholic Fatty Liver Disease Model: Insights into Molecular Mechanisms. | 2020 | Details |