Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A24127 | 23203768 | Mol Nutr Food Res | Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways. | 2012 | Details |
| A24131 | 23197979 | Gastroenterol Res Pract | Nutrition therapy for liver diseases based on the status of nutritional intake. | 2012 | Details |
| A24132 | 23197411 | Gut | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. | 2012 | Details |
| A24144 | 23183522 | J Hepatol | Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins. | 2012 | Details |
| A24154 | 23174781 | Hepatology | Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. | 2013 | Details |
| A24159 | 23169785 | Am J Physiol Endocrinol Metab | Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. | 2012 | Details |
| A24161 | 23165995 | Mol Nutr Food Res | miRNAs, polyphenols, and chronic disease. | 2012 | Details |
| A24162 | 23165534 | Nutr Hosp | Possible molecular mechanisms soy-mediated in preventing and treating nonalcoholic fatty liver disease. | 2013 | Details |
| A24180 | 23142626 | Gastroenterology | Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. | 2012 | Details |
| A24186 | 23141876 | Int J Cardiol | Non-alcoholic fatty liver disease and cardiovascular risk. | 2012 | Details |
| A24189 | 23139599 | World J Gastroenterol | Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. | 2012 | Details |
| A24194 | 23134073 | Clin Endocrinol (Oxf) | Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. | 2013 | Details |
| A24200 | 23127599 | Food Chem Toxicol | Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats. | 2012 | Details |
| A24218 | 23110104 | PLoS One | E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia. | 2012 | Details |
| A24242 | 23085008 | Biochim Biophys Acta | Dietary eicosapentaenoic acid supplementation accentuates hepatic triglyceride accumulation in mice with impaired fatty acid oxidation capacity. | 2012 | Details |
| A24249 | 23077135 | Gut | Whole-body substrate metabolism is associated with disease severity in patients with non-alcoholic fatty liver disease. | 2012 | Details |
| A24252 | 23073195 | Zhong Xi Yi Jie He Xue Bao | [Comparative study on the effects of different therapeutic methods in preventing and treating nonalcoholic fatty liver in rats]. | 2012 | Details |
| A24267 | 23063693 | Biochimie | A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα. | 2012 | Details |
| A24298 | 23028442 | PLoS One | Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. | 2012 | Details |
| A24304 | 23023705 | J Clin Invest | Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. | 2012 | Details |
| A24306 | 23022226 | Biochem Pharmacol | High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload. | 2012 | Details |
| A24311 | 23014486 | J Nutr | Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats. | 2012 | Details |
| A24313 | 23012396 | Physiol Genomics | Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression. | 2012 | Details |
| A24317 | 23002334 | World J Gastroenterol | Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis. | 2012 | Details |
| A24326 | 22997724 | Klin Med (Mosk) | [Pathogenetic therapy of metabolic syndrome at the stage of visceral lesions]. | 2012 | Details |
| A24328 | 22996622 | Hepatology | Hepatic fat loss in advanced nonalcoholic steatohepatitis: are alterations in serum adiponectin the cause? | 2013 | Details |
| A24333 | 22989301 | J Gastroenterol Hepatol | Fatty liver reduces hepatitis B virus replication in a genotype B hepatitis B virus transgenic mice model. | 2012 | Details |
| A24360 | 22969728 | Front Physiol | A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells. | 2012 | Details |
| A24361 | 22968990 | Mol Nutr Food Res | Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. | 2012 | Details |
| A24382 | 22952180 | Am J Clin Nutr | Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. | 2012 | Details |
| A24383 | 22952059 | Mol Med | Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response. | 2012 | Details |
| A24398 | 22935341 | Nutr Res | The lipid accumulation product is highly related to serum alanine aminotransferase level in male adults. | 2012 | Details |
| A24405 | 22932913 | Horm Metab Res | Reversion of steatosis by SREBP-1c antisense oligonucleotide did not improve hepatic insulin action in diet-induced obesity mice. | 2012 | Details |
| A24421 | 22914580 | AIDS | Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. | 2012 | Details |
| A24423 | 22913202 | Eur Rev Med Pharmacol Sci | Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats. | 2012 | Details |
| A24433 | 22899411 | Georgian Med News | Some aspects of pathogenesis of nonalcoholic fatty liver disease in postmenopausal women. | 2012 | Details |
| A24438 | 22893453 | Endocr J | Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver. | 2012 | Details |
| A24452 | 22878918 | Dig Dis Sci | Probucol ameliorates the development of nonalcoholic steatohepatitis in rats fed high-fat diets. | 2012 | Details |
| A24453 | 22878467 | J Hepatol | Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. | 2012 | Details |
| A24457 | 22876042 | World J Gastroenterol | Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo amplitude. | 2012 | Details |
| A24462 | 22872676 | FASEB J | Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. | 2012 | Details |
| A24468 | 22864747 | Arch Pharm Res | Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. | 2012 | Details |
| A24492 | 22843123 | Endocrine | Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development. | 2012 | Details |
| A24493 | 22841818 | Am J Pathol | Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. | 2012 | Details |
| A24511 | 22824479 | Clin Liver Dis | A myriad of pathways to NASH. | 2012 | Details |
| A24520 | 22819708 | Eur J Pharmacol | Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells. | 2012 | Details |
| A24548 | 22768070 | PLoS One | Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice. | 2012 | Details |
| A24557 | 22751691 | Diabetes | Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. | 2012 | Details |
| A24562 | 22749135 | J Nutr Biochem | The role of dietary fatty acids in the pathology of metabolic syndrome. | 2012 | Details |
| A24571 | 22739374 | J Nutr | Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. | 2012 | Details |
| A24595 | 22713601 | Lipids Health Dis | Fructose-rich diet leads to reduced aerobic capacity and to liver injury in rats. | 2012 | Details |
| A24607 | 22698815 | Toxicol Lett | Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice. | 2012 | Details |
| A24610 | 22692588 | Int J Mol Med | Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. | 2012 | Details |
| A24620 | 22684314 | Acta Diabetol | Nonalcoholic fatty liver and metabolic syndrome in Italy: results from a multicentric study of the Italian Arteriosclerosis society. | 2012 | Details |
| A24628 | 22674675 | Phytother Res | Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. | 2012 | Details |
| A24641 | 22659415 | Biochem Biophys Res Commun | GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model. | 2012 | Details |
| A24668 | 22633099 | Transl Res | Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. | 2012 | Details |
| A24671 | 22621222 | Histopathology | Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens. | 2012 | Details |
| A24674 | 22617751 | Curr Opin Lipidol | Nonalcoholic fatty liver disease and lipids. | 2012 | Details |
| A24692 | 22593713 | ScientificWorldJournal | Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease. | 2012 | Details |
| A24710 | 22572525 | Clin Res Hepatol Gastroenterol | The relationship between copper and steatosis in Wilson's disease. | 2012 | Details |
| A24714 | 22569763 | J Gastroenterol | Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease. | 2012 | Details |
| A24715 | 22569330 | Lipids Health Dis | Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. | 2012 | Details |
| A24723 | 22560219 | Cell Metab | Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. | 2012 | Details |
| A24733 | 22550592 | Int J Hepatol | Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol. | 2012 | Details |
| A24735 | 22546916 | Comp Med | Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in Guinea pigs. | 2012 | Details |
| A24736 | 22546860 | J Clin Invest | The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. | 2012 | Details |
| A24777 | 22508243 | Hepatology | Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. | 2013 | Details |
| A24780 | 22505276 | Hepatology | Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. | 2012 | Details |
| A24794 | 22484459 | Clin Biochem | Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation. | 2012 | Details |
| A24805 | 22470565 | PLoS One | Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. | 2012 | Details |
| A24821 | 22465531 | Gene | Two genetic variants in FABP1 and susceptibility to non-alcohol fatty liver disease in a Chinese population. | 2012 | Details |
| A24822 | 22465275 | Clin Biochem | Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease. | 2012 | Details |
| A24823 | 22464705 | Zhonghua Gan Zang Bing Za Zhi | [The effect of resistin on nuclear factor-kB and tumor necrosis factor-a expression in hepatic steatosis]. | 2012 | Details |
| A24831 | 22451385 | Biosci Biotechnol Biochem | Effects of lotus root (the edible rhizome of Nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice. | 2012 | Details |
| A24837 | 22442265 | J Clin Endocrinol Metab | Intrahepatic insulin exposure, intrahepatocellular lipid and regional body fat in nonalcoholic fatty liver disease. | 2012 | Details |
| A24842 | 22436747 | Nat Rev Mol Cell Biol | MicroRNAs in metabolism and metabolic disorders. | 2012 | Details |
| A24850 | 22433286 | Eur J Endocrinol | Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study. | 2012 | Details |
| A24851 | 22432836 | J Gastroenterol Hepatol | Assessment of inflammation and fibrosis in non-alcoholic fatty liver disease by imaging-based techniques. | 2012 | Details |
| A24859 | 22426118 | FASEB J | ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. | 2012 | Details |
| A24861 | 22425624 | J Hepatol | Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. | 2012 | Details |
| A24868 | 22418889 | Semin Liver Dis | Exercise and the liver: implications for therapy in fatty liver disorders. | 2012 | Details |
| A24876 | 22414386 | Toxicol Lett | Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. | 2012 | Details |
| A24894 | 22385956 | Cell | Mechanisms for insulin resistance: common threads and missing links. | 2012 | Details |
| A24899 | 22381945 | Phytomedicine | Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract. | 2012 | Details |
| A24900 | 22380754 | BMC Gastroenterol | Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease. | 2012 | Details |
| A24915 | 22364184 | J Agric Food Chem | Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways. | 2012 | Details |
| A24950 | 22326465 | J Hepatol | Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. | 2012 | Details |
| A24951 | 22326434 | Gastroenterology | Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. | 2012 | Details |
| A24969 | 22297300 | Am J Physiol Endocrinol Metab | Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals. | 2012 | Details |
| A24972 | 22294100 | Cell Mol Life Sci | A role for sphingolipids in the pathophysiology of obesity-induced inflammation. | 2012 | Details |
| A24982 | 22280920 | Physiol Behav | Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats. | 2012 | Details |
| A24992 | 22271167 | Hepatology | Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. | 2012 | Details |
| A24995 | 22268100 | Am J Physiol Gastrointest Liver Physiol | Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids. | 2012 | Details |
| A24999 | 22259190 | J Nutr | Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. | 2012 | Details |
| A25001 | 22257474 | J Dig Dis | Liver X receptors bridge hepatic lipid metabolism and inflammation. | 2012 | Details |
| A25018 | 22242926 | Metab Syndr Relat Disord | Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation. | 2012 | Details |
| A25021 | 22240297 | J Proteomics | Changes in hepatic protein expression in spontaneously hypertensive rats suggest early stages of non-alcoholic fatty liver disease. | 2012 | Details |
| A25025 | 22238690 | PLoS One | Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver. | 2012 | Details |
| A25034 | 22227333 | Eur J Pharmacol | Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. | 2011 | Details |