Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46847 | 12648414 | Zhonghua Gan Zang Bing Za Zhi | [Drug therapy for nonalcoholic fatty liver disease]. | 2003 | Details |
| A46906 | 34898362 | Bioengineered | microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism. | 2021 | Details |
| A46916 | 34423788 | JCI Insight | The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease. | 2021 | Details |
| A46918 | 34282217 | Sci Rep | Elevated S-adenosylhomocysteine induces adipocyte dysfunction to promote alcohol-associated liver steatosis. | 2021 | Details |
| A46924 | 34116071 | Toxicol Appl Pharmacol | Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. | 2021 | Details |
| A46929 | 33871024 | Clin Sci (Lond) | Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver. | 2021 | Details |
| A46930 | 33860120 | Hepatol Commun | Clinical Presentation and Gene Expression of Acute Alcohol-Induced Microvesicular Steatosis Mimicking Alcoholic Hepatitis. | 2021 | Details |
| A46933 | 33713857 | Biochem Biophys Res Commun | Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy. | 2021 | Details |
| A46935 | 33672832 | Biomolecules | Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis. | 2021 | Details |
| A46941 | 33352397 | Cytokine | IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice. | 2020 | Details |
| A46945 | 33162823 | Int J Biol Sci | Emerging Roles of SIRT1 in Alcoholic Liver Disease. | 2020 | Details |
| A46947 | 33067186 | Dis Model Mech | Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2 -/- animals. | 2020 | Details |
| A46962 | 32267550 | Alcohol Clin Exp Res | Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. | 2020 | Details |
| A46964 | 32129352 | Food Funct | Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis. | 2020 | Details |
| A46967 | 32045450 | PLoS One | Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress. | 2020 | Details |
| A46968 | 32045262 | Am J Physiol Endocrinol Metab | Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking. | 2020 | Details |
| A46980 | 31463983 | Lipids | Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice. | 2019 | Details |
| A46981 | 31438968 | Cell Commun Signal | Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation. | 2019 | Details |
| A46982 | 31336037 | Mol Nutr Food Res | The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy. | 2019 | Details |
| A46985 | 31265202 | IUBMB Life | Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling. | 2019 | Details |
| A46986 | 31241423 | J Am Coll Nutr | Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish. | 2019 | Details |
| A46989 | 31168926 | Mol Nutr Food Res | Myricetin Ameliorates Ethanol-Induced Lipid Accumulation in Liver Cells by Reducing Fatty Acid Biosynthesis. | 2019 | Details |
| A46997 | 30803859 | Dig Liver Dis | FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury. | 2019 | Details |
| A46998 | 30802717 | Redox Biol | Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. | 2019 | Details |
| A47001 | 30721374 | Cell Biol Toxicol | Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. | 2019 | Details |
| A47002 | 30660600 | Alcohol | Usefulness of adult medaka fish as a model for the evaluation of alcoholic fatty liver. | 2019 | Details |
| A47006 | 30256818 | PLoS One | Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease. | 2018 | Details |
| A47008 | 30192394 | Alcohol Clin Exp Res | Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis. | 2018 | Details |
| A47010 | 30150688 | Sci Rep | Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. | 2018 | Details |
| A47016 | 29852391 | Biomed Pharmacother | Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol-induced liver dysfunction: Rescue effect of ginger extract. | 2018 | Details |
| A47017 | 29763374 | Am J Physiol Endocrinol Metab | Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation. | 2018 | Details |
| A47020 | 29452206 | J Hepatol | SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. | 2018 | Details |
| A47022 | 29352167 | Sci Rep | SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice. | 2018 | Details |
| A47030 | 28941686 | Food Res Int | Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase. | 2017 | Details |
| A47032 | 28864659 | FASEB J | A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis. | 2017 | Details |
| A47037 | 28536109 | J Lipid Res | Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice. | 2017 | Details |
| A47041 | 28467182 | Exp Biol Med (Maywood) | Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease. | 2017 | Details |
| A47043 | 28274894 | J Ethnopharmacol | Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice. | 2017 | Details |
| A47051 | 27837167 | Toxicol Sci | Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes. | 2016 | Details |
| A47057 | 27666676 | Sci Rep | Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice. | 2016 | Details |
| A47061 | 27404390 | Sci Rep | Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis. | 2016 | Details |
| A47065 | 27220557 | Sci Rep | Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. | 2016 | Details |
| A47072 | 26858343 | Gut | Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors. | 2016 | Details |
| A47073 | 26854922 | Food Chem Toxicol | Ethanol and fatty acids impair lipid homeostasis in an in vitro model of hepatic steatosis. | 2016 | Details |
| A47077 | 26637972 | Biofactors | Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. | 2015 | Details |
| A47082 | 26564773 | Alcohol Alcohol | Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats. | 2015 | Details |
| A47090 | 26345299 | J Agric Food Chem | Gynura procumbens Reverses Acute and Chronic Ethanol-Induced Liver Steatosis through MAPK/SREBP-1c-Dependent and -Independent Pathways. | 2015 | Details |
| A47091 | 26305715 | IUBMB Life | Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. | 2015 | Details |
| A47093 | 26099526 | Gastroenterology | Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. | 2015 | Details |
| A47098 | 26022806 | J Lipid Res | Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver. | 2015 | Details |
| A47110 | 25833546 | Adv Exp Med Biol | Taurine accelerates alcohol and fat metabolism of rats with alcoholic Fatty liver disease. | 2015 | Details |
| A47115 | 25703252 | Alcohol Clin Exp Res | The adiponectin-SIRT1-AMPK pathway in alcoholic fatty liver disease in the rat. | 2015 | Details |
| A47118 | 25622859 | J Nutr Biochem | Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. | 2014 | Details |
| A47119 | 25595739 | Alcohol Alcohol | The role of lipin-1 in the pathogenesis of alcoholic fatty liver. | 2015 | Details |
| A47122 | 25561792 | World J Gastroenterol | Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. | 2014 | Details |
| A47125 | 25543082 | J Hepatol | Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. | 2014 | Details |
| A47126 | 25494594 | Lipids Health Dis | Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study. | 2014 | Details |
| A47129 | 25455889 | Food Chem Toxicol | Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | 2014 | Details |
| A47147 | 24859453 | J Hepatol | Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. | 2014 | Details |
| A47149 | 24833709 | Am J Physiol Gastrointest Liver Physiol | The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury. | 2014 | Details |
| A47150 | 24831094 | PLoS One | Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. | 2014 | Details |
| A47155 | 24793348 | J Clin Lipidol | Association between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia. | 2014 | Details |
| A47164 | 24513924 | Food Funct | Polyphenol-rich extract of Nelumbo nucifera leaves inhibits alcohol-induced steatohepatitis via reducing hepatic lipid accumulation and anti-inflammation in C57BL/6J mice. | 2014 | Details |
| A47166 | 24430730 | Sci Rep | Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis. | 2014 | Details |
| A47170 | 24269941 | Cell Signal | β-Lapachone alleviates alcoholic fatty liver disease in rats. | 2013 | Details |
| A47172 | 24262277 | Gastroenterology | Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. | 2013 | Details |
| A47176 | 24155903 | PLoS One | Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. | 2013 | Details |
| A47178 | 24117505 | Alcohol Clin Exp Res | Rab GTPases associate with isolated lipid droplets (LDs) and show altered content after ethanol administration: potential role in alcohol-impaired LD metabolism. | 2013 | Details |
| A47180 | 24063989 | Life Sci | Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. | 2013 | Details |
| A47182 | 23969550 | Alcohol Alcohol | Sex-specific differences in the development of acute alcohol-induced liver steatosis in mice. | 2013 | Details |
| A47190 | 23697887 | Zebrafish | Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. | 2013 | Details |
| A47194 | 23422163 | J Mol Cell Cardiol | Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J mice. | 2013 | Details |
| A47196 | 23337955 | Int J Mol Med | Analysis of differentially expressed genes and microRNAs in alcoholic liver disease. | 2013 | Details |
| A47200 | 23058988 | J Ethnopharmacol | Herbal medicines for the prevention of alcoholic liver disease: a review. | 2012 | Details |
| A47204 | 22988930 | J Gastroenterol Hepatol | Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-δ agonist treatment. | 2013 | Details |
| A47206 | 22905112 | PLoS One | Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. | 2012 | Details |
| A47208 | 22861370 | Clin Exp Immunol | Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltrates. | 2012 | Details |
| A47209 | 22841822 | Am J Pathol | Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. | 2012 | Details |
| A47222 | 22413959 | Alcohol Clin Exp Res | Carvedilol attenuates the progression of alcohol fatty liver disease in rats. | 2012 | Details |
| A47227 | 22234172 | Am J Pathol | Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. | 2012 | Details |
| A47228 | 22208561 | Lipids Health Dis | Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. | 2011 | Details |
| A47235 | 21896344 | J Hepatol | HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. | 2011 | Details |
| A47236 | 21856784 | J Lipid Res | Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. | 2011 | Details |
| A47240 | 21763219 | J Chromatogr B Analyt Technol Biomed Life Sci | Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. | 2011 | Details |
| A47246 | 21535024 | Alcohol Clin Exp Res | Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties. | 2011 | Details |
| A47247 | 21519326 | Lab Invest | The nuclear receptor CAR modulates alcohol-induced liver injury. | 2011 | Details |
| A47256 | 21087523 | J Transl Med | Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice. | 2010 | Details |
| A47257 | 20981870 | Phytother Res | Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. | 2010 | Details |
| A47266 | 20041784 | J Med Food | Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. | 2009 | Details |
| A47277 | 19588123 | Arch Toxicol | Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | 2009 | Details |
| A47284 | 19170661 | Alcohol Clin Exp Res | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Details |
| A47288 | 19013495 | Food Chem Toxicol | Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration. | 2008 | Details |
| A47300 | 18481025 | Arch Pharm Res | Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease. | 2008 | Details |
| A47305 | 18339590 | Dig Liver Dis | Inhibitory effect of osthole on alcohol-induced fatty liver in mice. | 2008 | Details |
| A47311 | 17655900 | Toxicol Appl Pharmacol | Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. | 2007 | Details |
| A47314 | 17453353 | Cell Biol Toxicol | Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver. | 2007 | Details |
| A47327 | 16958658 | J Gastroenterol Hepatol | Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. | 2006 | Details |
| A47331 | 16462037 | Biol Pharm Bull | Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. | 2006 | Details |
| A47340 | 15826726 | J Hepatol | Hepatic phospholipids in alcoholic liver disease assessed by proton-decoupled 31P magnetic resonance spectroscopy. | 2005 | Details |
| A47471 | 2058798 | Alcohol Clin Exp Res | Alterations in hepatic lipids and proteins by chronic ethanol intake: a high-pressure Fourier transform infrared spectroscopic study on alcoholic liver disease in the rat. | 1991 | Details |