Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A47531 | 2873160 | J Am Coll Nutr | Control of polyunsaturated acids in tissue lipids. | 1986 | Details |
| A47538 | 3158982 | Presse Med | [Non-alcoholic hepatic steatosis]. | 1985 | Details |
| A47573 | 6627849 | Clin Sci (Lond) | Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. | 1983 | Details |
| A47578 | 6416854 | Eur J Clin Invest | Hormone and metabolite profiles in alcoholic liver disease. | 1983 | Details |
| A47700 | 33484445 | Appl Biochem Biotechnol | Low Molecular Pectin Inhibited the Lipid Accumulation by Upregulation of METTL7B. | 2021 | Details |
| A47710 | 33163830 | Hepatol Commun | Donor Fecal Microbiota Transplantation Alters Gut Microbiota and Metabolites in Obese Individuals With Steatohepatitis. | 2020 | Details |
| A47737 | 32705602 | Adv Exp Med Biol | CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis. | 2020 | Details |
| A47739 | 32680936 | Diabetes | Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms. | 2020 | Details |
| A47778 | 32065514 | Clin Pharmacol Drug Dev | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study. | 2020 | Details |
| A47786 | 31936134 | Cells | Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. | 2020 | Details |
| A47806 | 31545919 | Am J Physiol Gastrointest Liver Physiol | Emerging role of extracellular vesicles in liver diseases. | 2019 | Details |
| A47824 | 31301451 | Clin Gastroenterol Hepatol | Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients. | 2019 | Details |
| A47826 | 31291759 | Arterioscler Thromb Vasc Biol | Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis. | 2019 | Details |
| A47916 | 29409022 | Endocrinology | Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice. | 2018 | Details |
| A47917 | 29404461 | Hepatol Commun | CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice. | 2017 | Details |
| A47925 | 29158695 | Hepat Med | PNPLA3 expression and its impact on the liver: current perspectives. | 2017 | Details |
| A47950 | 28513320 | Cancer Biol Ther | CRISPR/Cas9-based Pten knock-out and Sleeping Beauty Transposon-mediated Nras knock-in induces hepatocellular carcinoma and hepatic lipid accumulation in mice. | 2017 | Details |
| A47957 | 28236037 | Inflammopharmacology | PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. | 2017 | Details |
| A47969 | 27582390 | Mol Biol Cell | Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes. | 2016 | Details |
| A47989 | 27166937 | Cell Metab | Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. | 2016 | Details |
| A47998 | 26874804 | Clin Res Hepatol Gastroenterol | Bile acids in drug induced liver injury: Key players and surrogate markers. | 2016 | Details |
| A48053 | 25563794 | Menopause | Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model. | 2015 | Details |
| A48067 | 25213859 | J Biol Chem | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. | 2014 | Details |
| A48070 | 25092871 | Mol Cell Biol | Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes. | 2014 | Details |
| A48089 | 24424044 | Endocrinology | Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21. | 2014 | Details |
| A48107 | 23318884 | Lab Invest | Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. | 2013 | Details |
| A48114 | 22955269 | J Biol Chem | Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β. | 2012 | Details |
| A48121 | 22556142 | Am J Physiol Gastrointest Liver Physiol | Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat. | 2012 | Details |
| A48138 | 21830829 | J Proteome Res | A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations. | 2011 | Details |
| A48141 | 21697078 | Am J Clin Nutr | Disrupted fat distribution and composition due to medium-chain triglycerides in mice with a β-oxidation defect. | 2011 | Details |
| A48160 | 20974941 | Proc Natl Acad Sci U S A | Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. | 2010 | Details |
| A48164 | 20861239 | Endocrinology | Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. | 2010 | Details |
| A48182 | 20529882 | J Lipid Res | Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver. | 2010 | Details |
| A48195 | 20034031 | Hepatology | Lipidomic dissection of nonalcoholic steatohepatitis: moving beyond foie gras to fat traffic. | 2010 | Details |
| A48209 | 19735301 | Fundam Clin Pharmacol | Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity. | 2009 | Details |
| A48295 | 17135584 | N Engl J Med | A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. | 2006 | Details |
| A48305 | 17004324 | Traffic | Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. | 2006 | Details |
| A48310 | 16921198 | J Biol Chem | CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. | 2006 | Details |
| A48327 | 16407588 | Am J Physiol Gastrointest Liver Physiol | Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. | 2006 | Details |
| A48350 | 15634340 | FEBS J | Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading. | 2005 | Details |
| A48363 | 15199412 | J Clin Invest | Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. | 2004 | Details |
| A48423 | 11557505 | Am J Physiol Gastrointest Liver Physiol | Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. | 2001 | Details |
| A48487 | 3564380 | Vopr Pitan | [Role of modern diet therapy in the prevention of visceral complications in patients with dietary obesity]. | 1987 | Details |
| A48583 | 33624852 | J Food Biochem | Red yeast rice prevents chronic alcohol-induced liver disease by attenuating oxidative stress and inflammatory response in mice. | 2021 | Details |
| A48591 | 33477615 | Antioxidants (Basel) | The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial. | 2021 | Details |
| A48592 | 33455044 | Liver Int | Chanarin-Dorfman Syndrome: A comprehensive review. | 2021 | Details |
| A48613 | 33096030 | Clin Chim Acta | The apoM-S1P axis in hepatic diseases. | 2020 | Details |
| A48623 | 32772427 | Clin Exp Pharmacol Physiol | Effects of maternal high-fat/high sucrose diet on hepatic lipid metabolism in rat offspring. | 2020 | Details |
| A48625 | 32760397 | Front Immunol | Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis. | 2020 | Details |
| A48688 | 31479734 | Biochim Biophys Acta Mol Cell Biol Lipids | Low profile high value target: The role of OxLDL in cancer. | 2019 | Details |
| A48693 | 31401190 | Biochimie | Apolipoprotein A-I improves hepatic autophagy through the AMPK pathway. | 2019 | Details |
| A48728 | 30483228 | Front Microbiol | Alterations of Gut Microbiota in Cholestatic Infants and Their Correlation With Hepatic Function. | 2018 | Details |
| A48741 | 30165058 | Toxicol Appl Pharmacol | Nrf2 in alcoholic liver disease. | 2018 | Details |
| A48756 | 29597210 | Pharmacology | Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes. | 2018 | Details |
| A48775 | 29159825 | Hepatology | Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. | 2018 | Details |
| A48821 | 27618008 | Int J Mol Sci | Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations. | 2016 | Details |
| A48824 | 27498701 | Sci Rep | Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. | 2016 | Details |
| A48837 | 26997580 | Obes Rev | Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders. | 2016 | Details |
| A48857 | 26448681 | Mediators Inflamm | C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. | 2015 | Details |
| A48858 | 26443688 | Liver Int | Dietary fatty acids and risk of hepatocellular carcinoma in the Singapore Chinese health study. | 2015 | Details |
| A48880 | 25800177 | Pancreatology | Metabolic reprogramming and cell fate regulation in alcoholic liver disease. | 2015 | Details |
| A48896 | 25323790 | Cell Physiol Biochem | Hypoxia induces dysregulation of lipid metabolism in HepG2 cells via activation of HIF-2α. | 2014 | Details |
| A48902 | 25086218 | Biochim Biophys Acta | Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. | 2014 | Details |
| A48919 | 24489787 | PLoS One | Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices. | 2014 | Details |
| A48945 | 23607715 | Hepatol Res | Hepatic triglyceride lipase plays an essential role in changing the lipid metabolism in genotype 1b hepatitis C virus replicon cells and hepatitis C patients. | 2013 | Details |
| A48958 | 23184344 | Eur J Nutr | Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. | 2012 | Details |
| A48971 | 22801434 | Panminerva Med | Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases. | 2012 | Details |
| A48975 | 22543705 | Acta Pharmacol Sin | Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats. | 2012 | Details |
| A48981 | 22412843 | PLoS One | Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells. | 2012 | Details |
| A48984 | 22337830 | J Alzheimers Dis | Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed. | 2012 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49179 | 15368443 | Hepatology | Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. | 2004 | Details |
| A49201 | 35830798 | Cell Rep | RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis. | 2022 | Details |
| A49217 | 35819592 | Pharmacol Rep | Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism. | 2022 | Details |
| A49234 | 35813333 | Ann Transl Med | Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice. | 2022 | Details |
| A49243 | 35811725 | Front Cardiovasc Med | Glycation and a Spark of ALEs (Advanced Lipoxidation End Products) - Igniting RAGE/Diaphanous-1 and Cardiometabolic Disease. | 2022 | Details |
| A49257 | 35807929 | Nutrients | GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes. | 2022 | Details |
| A49276 | 35804007 | Sci Rep | IκBζ regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice. | 2022 | Details |
| A49284 | 35800450 | Front Pharmacol | Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation. | 2022 | Details |
| A49294 | 35796622 | Hepatology | RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling. | 2022 | Details |
| A49299 | 35795562 | Front Pharmacol | Multi-Omics Integration Analysis Identifies Lipid Disorder of a Non-Alcoholic Fatty Liver Disease (NAFLD) Mouse Model Improved by Zexie-Baizhu Decoction. | 2022 | Details |
| A49308 | 35792869 | FASEB J | Intestinal aberrant sphingolipid metabolism shaped-gut microbiome and bile acids metabolome in the development of hepatic steatosis. | 2022 | Details |
| A49325 | 35788089 | Chin Med J (Engl) | Bile acids and sphingolipids in non-alcoholic fatty liver disease. | 2022 | Details |
| A49331 | 35786482 | Sheng Wu Gong Cheng Xue Bao | [Lipid characteristics of fatty liver induced by high expression of Golgi protein 73]. | 2022 | Details |
| A49335 | 35784718 | Front Pharmacol | Multi-Omics Reveals Inhibitory Effect of Baicalein on Non-Alcoholic Fatty Liver Disease in Mice. | 2022 | Details |
| A49338 | 35784533 | Front Endocrinol (Lausanne) | Fufang Zhenzhu Tiaozhi Capsule Prevents Intestinal Inflammation and Barrier Disruption in Mice With Non-Alcoholic Steatohepatitis. | 2022 | Details |
| A49340 | 35783879 | Cureus | Nonalcoholic Fatty Liver Disease: An Emerging Modern-Day Risk Factor for Cardiovascular Disease. | 2022 | Details |
| A49342 | 35783288 | Front Genet | Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD. | 2022 | Details |
| A49348 | 35782337 | Gastroenterol Res Pract | Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49359 | 35779187 | Cell Stress Chaperones | Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. | 2022 | Details |
| A49361 | 35778734 | Cardiovasc Diabetol | TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients. | 2022 | Details |
| A49377 | 35769208 | Mediators Inflamm | MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice. | 2022 | Details |
| A49391 | 35765850 | Dis Model Mech | The liver-gut peripheral neural axis and nonalcoholic fatty liver disease pathologies via hepatic serotonin receptor 2A. | 2022 | Details |
| A49404 | 35761888 | Diabetes Metab Syndr Obes | Risk Factors for Nonalcoholic Fatty Liver Disease in Postmenopausal Women with Type 2 Diabetes Mellitus and the Correlation with Bone Mineral Density at Different Locations. | 2022 | Details |
| A49410 | 35759443 | Am J Physiol Cell Physiol | Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease. | 2022 | Details |
| A49415 | 35758365 | Medicine (Baltimore) | CONSORT-Characteristics and metabolic phenotype of gut microbiota in NAFLD patients. | 2022 | Details |
| A49443 | 35748073 | Yonsei Med J | Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy. | 2022 | Details |
| A49455 | 35745142 | Nutrients | Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice. | 2022 | Details |
| A49472 | 35743193 | Int J Mol Sci | A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-Induced Fatty Liver Diseases in Mice. | 2022 | Details |
| A49480 | 35740312 | Biomedicines | Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of "PCOS Males". | 2022 | Details |