Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A07023 | 32654534 | Arch Physiol Biochem | Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1/FAS and PPARα/UCP2 pathways. | 2020 | Details |
| A07033 | 32650421 | Cells | Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07093 | 32626560 | Middle East J Dig Dis | Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events. | 2020 | Details |
| A07095 | 32623698 | Cell Biol Toxicol | Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ. | 2020 | Details |
| A07107 | 32621046 | Cardiovasc Drugs Ther | Prolonged-release pirfenidone prevents obesity-induced cardiac steatosis and fibrosis in a mouse NASH model. | 2021 | Details |
| A07109 | 32620521 | Dig Liver Dis | Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration. | 2020 | Details |
| A07125 | 32613381 | Cell Biol Toxicol | Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. | 2020 | Details |
| A07128 | 32610115 | J Hepatol | Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials. | 2020 | Details |
| A07141 | 32605253 | Cancers (Basel) | Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07174 | 32592770 | Eur J Pharmacol | Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis. | 2020 | Details |
| A07181 | 32591883 | Eur Radiol | Comparing mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted MR imaging for stratifying non-alcoholic fatty liver disease in a rabbit model. | 2020 | Details |
| A07199 | 32585242 | Life Sci | IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. | 2020 | Details |
| A07220 | 32577122 | Nutr Metab (Lond) | TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter. | 2020 | Details |
| A07253 | 32566176 | Food Sci Nutr | Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice. | 2020 | Details |
| A07260 | 32562818 | Pharmacol Res | ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis. | 2020 | Details |
| A07303 | 32548088 | Front Chem | Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A07306 | 32546444 | Dig Liver Dis | Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators. | 2020 | Details |
| A07313 | 32543284 | Expert Opin Pharmacother | Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis. | 2020 | Details |
| A07329 | 32534989 | Chem Biol Interact | Roles of peroxisome proliferator-activated receptor α in the pathogenesis of ethanol-induced liver disease. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07378 | 32521450 | Biomed Pharmacother | Chinese herbal medicine mixture 919 syrup alleviates nonalcoholic fatty liver disease in rats by inhibiting the NF-κB pathway. | 2020 | Details |
| A07385 | 32518275 | Sci Rep | The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07425 | 32505733 | Clin Res Hepatol Gastroenterol | PPARγ gene Pro12Ala variants reduce the risk of obese individuals to non-alcoholic fatty liver: A study in Uygur Chinese population residing in Northwestern China. | 2020 | Details |
| A07428 | 32503411 | Mol Med | The protective effects of the β3 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD). | 2020 | Details |
| A07430 | 32502637 | Pharmacol Res | Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies. | 2020 | Details |
| A07449 | 32491288 | Physiol Int | Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis. | 2020 | Details |
| A07463 | 32485811 | Int J Mol Sci | Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease. | 2020 | Details |
| A07483 | 32477107 | Front Pharmacol | Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway. | 2020 | Details |
| A07486 | 32476787 | World J Gastroenterol | Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. | 2020 | Details |
| A07499 | 32472368 | AMB Express | Probiotic Bifidobacterium lactis V9 attenuates hepatic steatosis and inflammation in rats with non-alcoholic fatty liver disease. | 2020 | Details |
| A07514 | 32461397 | Indian J Med Res | Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome. | 2020 | Details |
| A07520 | 32460375 | J Food Sci | Effects of polar compounds in fried palm oil on liver lipid metabolism in C57 mice. | 2020 | Details |
| A07523 | 32457304 | Sci Rep | A Gilbert syndrome-associated haplotype protects against fatty liver disease in humanized transgenic mice. | 2020 | Details |
| A07525 | 32455208 | ACS Omega | Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats. | 2020 | Details |
| A07531 | 32454173 | J Ethnopharmacol | An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity. | 2020 | Details |
| A07538 | 32451200 | Arab J Gastroenterol | The roles and interaction of FXR and PPARs in the pathogenesis of nonalcoholic fatty liver disease. | 2020 | Details |
| A07588 | 32434697 | Transl Res | Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis. | 2020 | Details |
| A07613 | 32420361 | Biomed Res Int | Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation. | 2020 | Details |
| A07617 | 32419060 | Biochem Genet | Suppression of miR-30a-3p Attenuates Hepatic Steatosis in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A07622 | 32417163 | Chem Biol Interact | Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein. | 2020 | Details |
| A07641 | 32411189 | PPAR Res | Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet. | 2020 | Details |
| A07703 | 32385406 | Sci Rep | Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. | 2020 | Details |
| A07750 | 32365405 | J Gastroenterol Hepatol | Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A07769 | 32360434 | J Hepatol | Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆. | 2020 | Details |
| A07793 | 32353385 | Toxicol Appl Pharmacol | Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. | 2020 | Details |
| A07802 | 32351294 | World J Gastroenterol | Prevalence, clinical characteristics, risk factors, and indicators for lean Chinese adults with nonalcoholic fatty liver disease. | 2020 | Details |
| A07807 | 32350271 | Nat Commun | Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease. | 2020 | Details |
| A07818 | 32346285 | Drug Des Devel Ther | Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. | 2020 | Details |
| A07879 | 32325349 | Biomed Pharmacother | Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis. | 2020 | Details |
| A07938 | 32304952 | Environ Pollut | Exposure to 2,3,3',4,4',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice. | 2020 | Details |
| A07940 | 32304142 | FASEB J | Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model. | 2020 | Details |
| A07955 | 32300166 | Sci Rep | Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity. | 2020 | Details |
| A07958 | 32299444 | Lipids Health Dis | MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line. | 2020 | Details |
| A07961 | 32298755 | Mol Cell Endocrinol | The offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease. | 2020 | Details |
| A07965 | 32297157 | Virol Sin | Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients. | 2020 | Details |
| A07973 | 32293113 | J Cell Mol Med | Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways. | 2020 | Details |
| A07985 | 32289885 | Cell Biochem Funct | Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice. | 2020 | Details |
| A08014 | 32280349 | Case Rep Med | Clinical Case Series of Decrease in Shear Wave Elastography Values in Ten Diabetic Dyslipidemia Patients Having NAFLD with Saroglitazar 4 mg: An Indian Experience. | 2020 | Details |
| A08017 | 32279997 | Biochem Biophys Res Commun | Potential use of C-phycocyanin in non-alcoholic fatty liver disease. | 2020 | Details |
| A08041 | 32272794 | Animals (Basel) | Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry. | 2020 | Details |
| A08073 | 32258142 | Biomed Res Int | Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. | 2020 | Details |
| A08089 | 32251945 | Bioorg Chem | Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease. | 2020 | Details |
| A08101 | 32245586 | Chin J Nat Med | Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice. | 2020 | Details |
| A08108 | 32244266 | Int J Mol Sci | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. | 2020 | Details |
| A08131 | 32235813 | J Clin Med | Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD. | 2020 | Details |
| A08165 | 32220662 | Atherosclerosis | Relationship of fibroblast growth factor 21 levels with inflammation, lipoproteins and non-alcoholic fatty liver disease. | 2020 | Details |
| A08179 | 32217148 | Pharmacol Res | Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: Effects on metabolic parameters, anthropometric indices, and expression of PPAR-α, UCP1, and UCP2 genes. | 2020 | Details |
| A08223 | 32194141 | Immunol Lett | MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway. | 2020 | Details |
| A08231 | 32192216 | Int J Mol Sci | PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice. | 2020 | Details |
| A08243 | 32190149 | Arch Med Sci | Identification of key pathways and genes in nonalcoholic fatty liver disease using bioinformatics analysis. | 2020 | Details |
| A08246 | 32189432 | J Cell Mol Med | A network pharmacology-based approach to explore the effects of Chaihu Shugan powder on a non-alcoholic fatty liver rat model through nuclear receptors. | 2020 | Details |
| A08250 | 32188531 | J Dev Orig Health Dis | Administration of ursolic acid to new-born pups prevents dietary fructose-induced non-alcoholic fatty liver disease in Sprague Dawley rats. | 2020 | Details |
| A08270 | 32176760 | J Gastrointestin Liver Dis | Nonalcoholic Fatty Liver Disease as a Risk Factor for Prolonged Corrected QT Interval in Apparently Healthy Korean Women. | 2020 | Details |
| A08283 | 32169759 | Biomed Pharmacother | Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways. | 2020 | Details |
| A08306 | 32158445 | Front Immunol | CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism. | 2020 | Details |
| A08313 | 32156377 | Food Res Int | Effect of okra fruit powder supplementation on metabolic syndrome and gut microbiota diversity in high fat diet-induced obese mice. | 2019 | Details |
| A08327 | 32151660 | Metabolism | Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis. | 2020 | Details |
| A08376 | 32138593 | Prion | The role of cellular prion protein in lipid metabolism in the liver. | 2020 | Details |
| A08393 | 32128893 | J Gastroenterol Hepatol | Regulation of lipid-induced macrophage polarization through modulating peroxisome proliferator-activated receptor-gamma activity affects hepatic lipid metabolism via a Toll-like receptor 4/NF-κB signaling pathway. | 2020 | Details |
| A08410 | 32123241 | Sci Rep | Self-rated health and risk of incident non-alcoholic fatty liver disease: A cohort study. | 2020 | Details |
| A08455 | 32104276 | Exp Ther Med | Atorvastatin promotes AMPK signaling to protect against high fat diet-induced non-alcoholic fatty liver in golden hamsters. | 2020 | Details |
| A08489 | 32090345 | J Food Sci | Effects and molecular mechanisms of Ninghong black tea extract in nonalcoholic fatty liver disease of rats. | 2020 | Details |
| A08559 | 32061597 | Gastroenterology | Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease. | 2020 | Details |
| A08569 | 32058041 | J Proteomics | Proteomic analysis to identify differentially expressed proteins between subjects with metabolic healthy obesity and non-alcoholic fatty liver disease. | 2020 | Details |
| A08613 | 32042044 | Nat Commun | Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase. | 2020 | Details |
| A08671 | 32027126 | J Chem Inf Model | Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation. | 2020 | Details |
| A08763 | 31993314 | Acta Pharm Sin B | Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice. | 2019 | Details |
| A08794 | 31982006 | Wiad Lek | The role of hydrogen sulfide in the progression of chronic obstructive pulmonary disease in patients with non-alcoholic steatohepatitis | 2019 | Details |
| A08822 | 31978277 | Mol Nutr Food Res | Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. | 2020 | Details |
| A08826 | 31975365 | Histol Histopathol | Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats. | 2020 | Details |
| A08827 | 31975362 | Planta Med | Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis. | 2020 | Details |
| A08829 | 31974594 | Mol Med Rep | Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. | 2019 | Details |
| A08883 | 31953228 | Biochim Biophys Acta Mol Cell Biol Lipids | Effects of peptidoglycan on the development of steatohepatitis. | 2020 | Details |
| A08907 | 31942560 | Animal Model Exp Med | A simple method for inducing nonalcoholic steatohepatitis with fibrosis. | 2019 | Details |
| A08925 | 31935815 | Int J Mol Sci | Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway. | 2020 | Details |
| A08933 | 31931543 | Z Gastroenterol | [What is the (right) target for non-alcoholic fatty liver disease (NAFLD)?] | 2020 | Details |
| A08936 | 31930920 | J Med Chem | The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. | 2020 | Details |
| A08940 | 31930271 | Food Funct | The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. | 2020 | Details |
| A08946 | 31929156 | J Alzheimers Dis | Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling. | 2020 | Details |
| A08954 | 31926984 | J Ethnopharmacol | Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response. | 2020 | Details |