Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A04732 | 33523759 | J Med Food | Jaboticaba (Myrciaria cauliflora) Peel Supplementation Prevents Hepatic Steatosis Through Hypolipidemic Effects and Cholesterol Metabolism Modulation in Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model. | 2021 | Details |
| A04741 | 33517848 | Can J Physiol Pharmacol | Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production. | 2021 | Details |
| A04747 | 33515803 | Ann Hepatol | Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis. | 2021 | Details |
| A04763 | 33513397 | Life Sci | The influence of PM2.5 exposure on non-alcoholic fatty liver disease. | 2021 | Details |
| A04764 | 33513383 | J Steroid Biochem Mol Biol | Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats. | 2021 | Details |
| A04783 | 33506572 | Liver Int | Fibroblast Growth Factor 19: Potential modulation of hepatic metabolism for the treatment of non-alcoholic fatty liver disease. | 2021 | Details |
| A04784 | 33505944 | Can J Gastroenterol Hepatol | Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases: The Heart of the Matter. | 2021 | Details |
| A04806 | 33498684 | Plants (Basel) | Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease. | 2021 | Details |
| A04812 | 33497819 | Biochim Biophys Acta Mol Basis Dis | Non-coding RNA crosstalk with nuclear receptors in liver disease. | 2021 | Details |
| A04818 | 33494735 | BMC Complement Med Ther | Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis. | 2021 | Details |
| A04820 | 33494295 | Cells | Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways. | 2021 | Details |
| A04828 | 33491665 | JCI Insight | Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. | 2021 | Details |
| A04830 | 33491316 | Obesity (Silver Spring) | Fecal Fungi Dysbiosis in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04876 | 33470903 | Am J Physiol Gastrointest Liver Physiol | GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration. | 2021 | Details |
| A04882 | 33468321 | Trends Pharmacol Sci | Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent. | 2021 | Details |
| A04883 | 33467660 | Int J Mol Sci | Common Transcriptional Program of Liver Fibrosis in Mouse Genetic Models and Humans. | 2021 | Details |
| A04888 | 33465519 | Mol Metab | Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes. | 2021 | Details |
| A04915 | 33450482 | Biochem Biophys Res Commun | Hypoxia-inducible factor-2 promotes liver fibrosis in non-alcoholic steatohepatitis liver disease via the NF-κB signalling pathway. | 2021 | Details |
| A04916 | 33450094 | J Physiol | Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex-specific manner. | 2021 | Details |
| A04925 | 33446707 | Sci Rep | The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis. | 2021 | Details |
| A04934 | 33444725 | J Ethnopharmacol | Anti-NAFLD effect of defatted walnut powder extract in high fat diet-induced C57BL/6 mice by modulating the gut microbiota. | 2021 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A04995 | 33421522 | Life Sci | Obesity-induced upregulation of microRNA-183-5p promotes hepatic triglyceride accumulation by targeting the B-cell translocation gene 1. | 2021 | Details |
| A05003 | 33417955 | Life Sci | Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats. | 2021 | Details |
| A05005 | 33415161 | Biomed Res Int | Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation. | 2020 | Details |
| A05008 | 33413060 | Curr Med Chem | Lipid Metabolism and Relevant Disorders to Female Reproductive Health. | 2021 | Details |
| A05019 | 33409397 | Transl Gastroenterol Hepatol | Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). | 2021 | Details |
| A05025 | 33406763 | Int J Mol Sci | Immunity as Cornerstone of Non-Alcoholic Fatty Liver Disease: The Contribution of Oxidative Stress in the Disease Progression. | 2021 | Details |
| A05029 | 33404166 | Int J Clin Pract | The association of the adipokine zinc-alpha2-glycoprotein with non-alcoholic fatty liver disease and related risk factors: A comprehensive systematic review. | 2021 | Details |
| A05034 | 33400402 | J Cell Mol Med | Val-Val-Tyr-Pro protects against non-alcoholic steatohepatitis in mice by modulating the gut microbiota and gut-liver axis activation. | 2021 | Details |
| A05045 | 33396456 | Antioxidants (Basel) | Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food. | 2020 | Details |
| A05064 | 33390398 | J Nutr Sci Vitaminol (Tokyo) | Gene Expression and Histochemical Analyses in the Fatty Livers of Rats Fed a Histidine-Excess Diet. | 2020 | Details |
| A05093 | 33379170 | Molecules | Synthesis, Photoisomerization, Antioxidant Activity, and Lipid-Lowering Effect of Ferulic Acid and Feruloyl Amides. | 2020 | Details |
| A05098 | 33377125 | Cell Rep Med | Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes. | 2020 | Details |
| A05099 | 33377114 | STAR Protoc | Isolation, culture, and functional analysis of hepatocytes from mice with fatty liver disease. | 2020 | Details |
| A05111 | 33372064 | Biol Open | A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. | 2021 | Details |
| A05118 | 33369197 | Mol Nutr Food Res | Punicalagin Prevents Hepatic Steatosis through Improving Lipid Homeostasis and Inflammation in Liver and Adipose Tissue and Modulating Gut Microbiota in Western Diet-Fed Mice. | 2021 | Details |
| A05133 | 33361348 | Gut | RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease. | 2020 | Details |
| A05136 | 33359683 | Free Radic Biol Med | ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05137 | 33359401 | Mol Metab | Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease. | 2020 | Details |
| A05154 | 33352441 | Int Immunopharmacol | Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses. | 2020 | Details |
| A05165 | 33348067 | Mol Metab | Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD). | 2021 | Details |
| A05169 | 33347879 | Gastroenterology | Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease. | 2021 | Details |
| A05177 | 33346069 | Mol Metab | Metabolic drivers of non-alcoholic fatty liver disease. | 2020 | Details |
| A05185 | 33343508 | Front Endocrinol (Lausanne) | ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue. | 2020 | Details |
| A05187 | 33343352 | Front Pharmacol | Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05192 | 33341045 | Biomed Pharmacother | β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway. | 2020 | Details |
| A05212 | 33337101 | Compr Rev Food Sci Food Saf | Phytosterols and their derivatives: Potential health-promoting uses against lipid metabolism and associated diseases, mechanism, and safety issues. | 2020 | Details |
| A05221 | 33334026 | Int J Mol Sci | Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation. | 2020 | Details |
| A05243 | 33327227 | Medicine (Baltimore) | Study on the new strategy and key techniques for accurate prevention and treatment of nonalcoholic steatohepatitis based on intestinal target bacteria. | 2020 | Details |
| A05245 | 33326461 | PLoS One | The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model. | 2020 | Details |
| A05247 | 33325808 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05253 | 33322323 | Animals (Basel) | GC-TOF-MS-Based Metabolomics Analyses of Liver and Intestinal Contents in the Overfed vs. Normally-Fed Geese. | 2020 | Details |
| A05256 | 33321020 | Acta Gastroenterol Belg | Proteins involved in lipid metabolism as possible biomarkers or predisposing factors for non-alcoholic fatty liver disease. | 2020 | Details |
| A05260 | 33320545 | ACS Biomater Sci Eng | Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System. | 2020 | Details |
| A05261 | 33320482 | Postepy Biochem | Transcription factor ChREBP – the coordinator of carbohydrate and lipid metabolism | 2020 | Details |
| A05263 | 33320193 | Endocrinology | The Importance of Keeping Time in the Liver. | 2021 | Details |
| A05270 | 33318479 | Cell Death Dis | Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner. | 2020 | Details |
| A05295 | 33309929 | J Proteomics | Proteome and phosphoproteome characterization of liver in the postprandial state from diet-induced obese and lean mice. | 2020 | Details |
| A05318 | 33303970 | Lab Invest | Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. | 2020 | Details |
| A05323 | 33302736 | Exp Biol Med (Maywood) | Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. | 2020 | Details |
| A05326 | 33302316 | Horm Metab Res | Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice. | 2020 | Details |
| A05327 | 33301513 | PLoS One | RYGB increases postprandial gastric nesfatin-1 and rapid relieves NAFLD via gastric nerve detachment. | 2020 | Details |
| A05329 | 33300526 | Food Funct | Improvement of the hepatic lipid status in intrauterine growth retarded pigs by resveratrol is related to the inhibition of mitochondrial dysfunction, oxidative stress and inflammation. | 2020 | Details |
| A05332 | 33299856 | Biomed Res Int | GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis. | 2020 | Details |
| A05343 | 33294458 | Biomed Res Int | APOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic Inflammation in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05344 | 33293992 | Evid Based Complement Alternat Med | Effect of Sheng-Jiang Powder on Gut Microbiota in High-Fat Diet-Induced NAFLD. | 2020 | Details |
| A05351 | 33290156 | Can J Physiol Pharmacol | Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro. | 2020 | Details |
| A05352 | 33289350 | Diabetes Obes Metab | Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. | 2020 | Details |
| A05355 | 33284502 | Hepatology | Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. | 2021 | Details |
| A05360 | 33282902 | Front Nutr | Maternal High-Fat Diet Leads to Non-alcoholic Fatty Liver Disease Through Upregulating Hepatic SCD1 Expression in Neonate Rats. | 2020 | Details |
| A05366 | 33281535 | Food Nutr Res | Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model. | 2020 | Details |
| A05374 | 33278735 | Curr Opin Pharmacol | The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes. | 2020 | Details |
| A05375 | 33278596 | Biochim Biophys Acta Mol Cell Biol Lipids | Systems biology approaches to study lipidomes in health and disease. | 2020 | Details |
| A05380 | 33276146 | Mol Metab | Mitochondrial oxidative function in NAFLD: Friend or foe? | 2020 | Details |
| A05388 | 33273997 | Oxid Med Cell Longev | Plant Sterol Ester of α-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial Biogenesis. | 2019 | Details |
| A05393 | 33272734 | Gastroenterol Hepatol | Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway. | 2020 | Details |
| A05396 | 33271781 | Int J Mol Sci | Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05397 | 33271332 | Mol Metab | Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis. | 2020 | Details |
| A05399 | 33270924 | J Bone Miner Res | Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models. | 2020 | Details |
| A05422 | 33263565 | J Endocrinol | Overexpression of the Lias gene attenuates hepatic steatosis in Leprdb/db mice. | 2021 | Details |
| A05423 | 33262120 | Diabetes | A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo. | 2020 | Details |
| A05429 | 33260239 | Horm Metab Res | The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice. | 2020 | Details |
| A05430 | 33259845 | J Hepatol | Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus. | 2020 | Details |
| A05438 | 33257471 | Gut | Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance. | 2020 | Details |
| A05445 | 33254688 | Environ Pollut | Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes. | 2020 | Details |
| A05450 | 33252713 | Protein Cell | Targeting the alternative bile acid synthetic pathway for metabolic diseases. | 2020 | Details |
| A05472 | 33246954 | Sci Adv | CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression. | 2020 | Details |
| A05479 | 33242590 | Biochim Biophys Acta Mol Basis Dis | Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy. | 2020 | Details |
| A05484 | 33238880 | Mol Med | Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding. | 2020 | Details |
| A05493 | 33234364 | Phytomedicine | Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1. | 2020 | Details |
| A05500 | 33228663 | J Transl Med | LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis. | 2020 | Details |
| A05505 | 33227217 | J Med Food | Whole Red Raspberry (Rubus idaeus)-Enriched Diet Is Hepatoprotective in the Obese Zucker Rat, a Model of the Metabolic Syndrome. | 2020 | Details |
| A05514 | 33220492 | Mol Metab | Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans. | 2020 | Details |
| A05515 | 33220489 | Mol Metab | Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease. | 2020 | Details |
| A05516 | 33220425 | Free Radic Biol Med | Physiological evidence of mitochondrial permeability transition pore opening caused by lipid deposition leading to hepatic steatosis in db/db mice. | 2020 | Details |
| A05535 | 33216087 | Food Funct | Amelioration of non-alcoholic fatty liver disease by sodium butyrate is linked to the modulation of intestinal tight junctions in db/db mice. | 2020 | Details |
| A05568 | 33204402 | Oxid Med Cell Longev | Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice. | 2020 | Details |
| A05570 | 33203828 | Med Sci Monit | Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout. | 2020 | Details |