Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Insulin9623 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46757 | 15842599 | Am J Gastroenterol | The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease. | 2005 | Details |
| A46759 | 15810122 | Gastroenterology | Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease. | 2005 | Details |
| A46760 | 15795412 | CMAJ | Nonalcoholic fatty liver disease. | 2005 | Details |
| A46762 | 15779390 | Nihon Rinsho | [Impaired glucose tolerance in nonalcoholic fatty liver disease]. | 2005 | Details |
| A46765 | 15730035 | Ned Tijdschr Geneeskd | [Nonalcoholic steatohepatitis: diagnosis, pathogenesis, treatment and prognosis]. | 2005 | Details |
| A46771 | 15705403 | Fertil Steril | Abnormal aminotransferase activity in women with polycystic ovary syndrome. | 2005 | Details |
| A46772 | 15703643 | Curr Opin Gastroenterol | Hepatobiliary pathology. | 2004 | Details |
| A46773 | 15703606 | Curr Opin Gastroenterol | Innate immunity in the liver. | 2003 | Details |
| A46775 | 15682682 | J Investig Med | Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies. | 2004 | Details |
| A46776 | 15670659 | Alcohol | Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. | 2004 | Details |
| A46779 | 15632182 | J Biol Chem | Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. | 2005 | Details |
| A46785 | 15598693 | J Clin Endocrinol Metab | Insulin resistance, the metabolic syndrome, and nonalcoholic fatty liver disease. | 2004 | Details |
| A46788 | 15547646 | Angiology | Prevention and treatment of the metabolic syndrome. | 2005 | Details |
| A46801 | 15331066 | Clin Liver Dis | Mitochondria in nonalcoholic fatty liver disease. | 2004 | Details |
| A46802 | 15262299 | Endocrinol Metab Clin North Am | Glitazones and the management of insulin resistance: what they do and how might they be used. | 2004 | Details |
| A46803 | 15254578 | J Clin Invest | Molecular mediators of hepatic steatosis and liver injury. | 2004 | Details |
| A46804 | 15240880 | Proc Natl Acad Sci U S A | Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. | 2004 | Details |
| A46806 | 15195530 | Gastroenterol Hepatol | [Pathogenesis of non-alcoholic fatty liver and potential therapeutic targets]. | 2004 | Details |
| A46808 | 15151470 | Expert Rev Cardiovasc Ther | Treatment of metabolic syndrome. | 2004 | Details |
| A46809 | 15122714 | Ann Neurol | Valproate therapy and nonalcoholic fatty liver disease. | 2004 | Details |
| A46811 | 15051828 | J Nutr | Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes. | 2004 | Details |
| A46814 | 14985206 | Am J Clin Nutr | Another animal model for nonalcoholic steatohepatitis: how close to the human condition? | 2004 | Details |
| A46817 | 14749503 | Recent Prog Horm Res | Obesity, insulin resistance, and cardiovascular disease. | 2004 | Details |
| A46820 | 14698985 | Endocr Pract | Insulin resistance syndrome and nonalcoholic fatty liver disease. | 2004 | Details |
| A46830 | 14499793 | Am J Gastroenterol | Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach. | 2003 | Details |
| A46833 | 12957298 | Alcohol | Iron as a co-morbid factor in nonhemochromatotic liver disease. | 2003 | Details |
| A46834 | 12920429 | Gastroenterol Nurs | Nonalcoholic Fatty liver disease. | 2003 | Details |
| A46840 | 12809815 | Am J Gastroenterol | The prevalence and etiology of elevated aminotransferase levels in the United States. | 2003 | Details |
| A46843 | 12779071 | Dig Liver Dis | Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis. | 2003 | Details |
| A46844 | 12768390 | J Gastroenterol | Serum leptin level can be a negative marker of hepatocyte damage in nonalcoholic fatty liver. | 2003 | Details |
| A46846 | 12648420 | Zhonghua Gan Zang Bing Za Zhi | [Current therapy strategies for nonalcoholic fatty liver disease]. | 2003 | Details |
| A46848 | 12648413 | Zhonghua Gan Zang Bing Za Zhi | [The role of improving insulin-resistant in the treatment and prevention of nonalcoholic fatty liver disease]. | 2003 | Details |
| A46860 | 12408779 | Curr Treat Options Gastroenterol | Therapeutic Options in Nonalcoholic Fatty Liver Disease. | 2002 | Details |
| A46879 | 11832442 | Gastroenterology | Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. | 2002 | Details |
| A46886 | 11360453 | Dtsch Med Wochenschr | [Nonalcoholic steatohepatitis: epidemiology, diagnosis and treatment]. | 2001 | Details |
| A46889 | 11296700 | Semin Liver Dis | Animal models of steatosis. | 2001 | Details |
| A46892 | 11296693 | Semin Liver Dis | Clinical features and natural history of nonalcoholic steatosis syndromes. | 2001 | Details |
| A46893 | 11293184 | Indian J Gastroenterol | Nonalcoholic steatohepatitis. | 2001 | Details |
| A46897 | 11032566 | Am J Med | Nonalcoholic fatty liver disease is associated with hyperlipidemia and obesity. | 2000 | Details |
| A46966 | 32087348 | J Hepatol | Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. | 2020 | Details |
| A46998 | 30802717 | Redox Biol | Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. | 2019 | Details |
| A47001 | 30721374 | Cell Biol Toxicol | Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. | 2019 | Details |
| A47012 | 30105955 | Exp Biol Med (Maywood) | Mulberry and dandelion water extracts prevent alcohol-induced steatosis with alleviating gut microbiome dysbiosis. | 2018 | Details |
| A47018 | 29708448 | Expert Opin Pharmacother | Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. | 2018 | Details |
| A47029 | 29095436 | Cell Death Dis | RNA-sequencing-based comparative analysis of human hepatic progenitor cells and their niche from alcoholic steatohepatitis livers. | 2017 | Details |
| A47050 | 27861855 | Int J Cancer | Effect of statin on hepatocellular carcinoma in patients with type 2 diabetes: A nationwide nested case-control study. | 2016 | Details |
| A47080 | 26610588 | Biomolecules | High Intrinsic Aerobic Capacity Protects against Ethanol-Induced Hepatic Injury and Metabolic Dysfunction: Study Using High Capacity Runner Rat Model. | 2015 | Details |
| A47094 | 26092866 | J Lipid Res | FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. | 2015 | Details |
| A47106 | 25892964 | Int J Biol Sci | The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. | 2015 | Details |
| A47154 | 24797033 | Alcohol Clin Exp Res | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. | 2014 | Details |
| A47191 | 23682678 | Liver Int | Circulating MicroRNAs as potential biomarkers for alcoholic steatohepatitis. | 2013 | Details |
| A47204 | 22988930 | J Gastroenterol Hepatol | Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-δ agonist treatment. | 2013 | Details |
| A47211 | 22745073 | Am J Chin Med | Protective effects of total flavonoids from Litsea coreana on alcoholic fatty liver in rats associated with down-regulation adipose differentiation-related protein expression. | 2012 | Details |
| A47227 | 22234172 | Am J Pathol | Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. | 2012 | Details |
| A47239 | 21790669 | Alcohol Clin Exp Res | Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. | 2011 | Details |
| A47292 | 18722787 | Cytokine | Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. | 2008 | Details |
| A47297 | 18534708 | Diabetes Res Clin Pract | Fatty liver and chronic inflammation in Chinese adults. | 2008 | Details |
| A47336 | 16170395 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy. | 2005 | Details |
| A47337 | 16115302 | J Intern Med | Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. | 2005 | Details |
| A47384 | 10222605 | Zhonghua Yi Xue Za Zhi (Taipei) | Non-insulin-dependent diabetes mellitus with type I multiple symmetrical lipomatosis: a case report. | 1999 | Details |
| A47578 | 6416854 | Eur J Clin Invest | Hormone and metabolite profiles in alcoholic liver disease. | 1983 | Details |
| A47598 | 6345169 | Eur Surg Res | Effects on the exocrine and endocrine pancreas of duct occlusion with two different tissue glues in the rat. | 1983 | Details |
| A47609 | 35156314 | Obesity (Silver Spring) | Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance. | 2022 | Details |
| A47616 | 35053615 | Cancers (Basel) | CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma. | 2022 | Details |
| A47630 | 34732847 | Lab Invest | Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice. | 2021 | Details |
| A47677 | 33829335 | Surg Today | Predictive scoring system for advanced liver fibrosis in Japanese patients with severe obesity. | 2021 | Details |
| A47679 | 33778934 | Clin Pharmacokinet | Effects of Renal Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide. | 2021 | Details |
| A47684 | 33738905 | Obes Rev | Neutral sphingomyelinase-2 and cardiometabolic diseases. | 2021 | Details |
| A47719 | 33030356 | Expert Rev Endocrinol Metab | Tirzepatide: a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) dual agonist in development for the treatment of type 2 diabetes. | 2020 | Details |
| A47728 | 32830851 | J Clin Endocrinol Metab | Identification of Proteins Associated with the Early Restoration of Insulin Sensitivity After Biliopancreatic Diversion. | 2020 | Details |
| A47735 | 32730231 | JCI Insight | Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. | 2020 | Details |
| A47737 | 32705602 | Adv Exp Med Biol | CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis. | 2020 | Details |
| A47770 | 32213649 | Endocrinol Diabetes Metab Case Rep | The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide. | 2020 | Details |
| A47815 | 31434650 | Diabetes Care | Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes. | 2019 | Details |
| A47850 | 30976746 | Hepatol Commun | Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation. | 2019 | Details |
| A47857 | 30759233 | J Clin Endocrinol Metab | Massive Ovarian Growth in a Woman With Severe Insulin-Resistant Polycystic Ovary Syndrome Receiving GnRH Analogue. | 2019 | Details |
| A47858 | 30742277 | Drugs | The Impact of Comorbidities on the Pharmacological Management of Type 2 Diabetes Mellitus. | 2019 | Details |
| A47873 | 30393432 | J Toxicol Pathol | Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model. | 2018 | Details |
| A47890 | 29991462 | Ann Biol Clin (Paris) | [Factitious hypoglycemia : "a never-ending story"?] | 2018 | Details |
| A47896 | 29870275 | Diabetes Technol Ther | The Clinical Impact of GLP-1 Receptor Agonists in Type 2 Diabetes: Focus on the Long-Acting Analogs. | 2018 | Details |
| A47900 | 29733507 | Mol Nutr Food Res | High Fat Diets Composed of Palm Stearin and Olive Oil Equally Exacerbate Liver Inflammatory Damage and Metabolic Stress in Mice. | 2018 | Details |
| A47904 | 29607946 | Intern Med | Clinical Characteristics, Phenotype of Lipodystrophy and a Genetic Analysis of Six Diabetic Japanese Women with Familial Partial Lipodystrophy in a Diabetic Outpatient Clinic. | 2018 | Details |
| A47913 | 29411291 | Diabetes Ther | Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment. | 2018 | Details |
| A47935 | 28847797 | Circulation | Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors. | 2017 | Details |
| A47939 | 28708468 | J Med Food | A Botanical Composition from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis for Body Weight Management. | 2017 | Details |
| A47960 | 28098353 | J Cell Physiol | The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice. | 2017 | Details |
| A47965 | 27907186 | PLoS One | Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals. | 2016 | Details |
| A47972 | 27765759 | Am J Physiol Gastrointest Liver Physiol | Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy. | 2016 | Details |
| A47974 | 27659424 | Am J Physiol Gastrointest Liver Physiol | Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity. | 2016 | Details |
| A47990 | 27110066 | Mediators Inflamm | Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control. | 2016 | Details |
| A48016 | 26486483 | Vnitr Lek | [Polycystic ovary syndrome]. | 2015 | Details |
| A48042 | 25866507 | Gastroenterol Res Pract | Treatment of nonalcoholic steatohepatitis in adults: present and future. | 2015 | Details |
| A48066 | 25255039 | J Med Chem | Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. | 2014 | Details |
| A48067 | 25213859 | J Biol Chem | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. | 2014 | Details |
| A48085 | 24585431 | Hepatology | Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes. | 2014 | Details |
| A48092 | 24204981 | PLoS One | Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. | 2013 | Details |
| A48093 | 24167462 | Mol Syndromol | FTO and INSIG2 Genotyping Combined with Metabolic and Anthropometric Phenotyping of Morbidly Obese Patients. | 2013 | Details |
| A48094 | 24096983 | J Gastroenterol | Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension. | 2013 | Details |
| A48099 | 23709089 | Endocrinology | High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. | 2013 | Details |
| A48107 | 23318884 | Lab Invest | Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. | 2013 | Details |