Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14358 | 29450137 | Biochim Open | Liver and Metformin: Lessons of a fructose diet in mice. | 2017 | Details |
| A14363 | 29446839 | Lipids | Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity. | 2018 | Details |
| A14374 | 29439143 | Biosci Rep | Anarchy in the UPR: A Ca2+-insensitive PKC inhibits SERCA activity to promote ER stress. | 2018 | Details |
| A14404 | 29426937 | Nat Commun | Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. | 2018 | Details |
| A14409 | 29421523 | Transl Res | Maraviroc improves hepatic triglyceride content but not inflammation in a murine nonalcoholic fatty liver disease model induced by a chronic exposure to high-fat diet. | 2018 | Details |
| A14420 | 29414781 | J Biol Chem | Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway. | 2018 | Details |
| A14435 | 29408694 | J Hepatol | Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. | 2018 | Details |
| A14453 | 29404440 | Hepatol Commun | Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14485 | 29389988 | PLoS One | Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis. | 2018 | Details |
| A14494 | 29382663 | Diabetes | Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis. | 2018 | Details |
| A14498 | 29380318 | Methods Mol Biol | Assessment of Fatty Liver in Models of Disease Programming. | 2018 | Details |
| A14518 | 29371998 | Toxicol Res | Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |
| A14531 | 29366871 | Food Chem Toxicol | Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. | 2018 | Details |
| A14541 | 29361497 | Mol Metab | Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR. | 2018 | Details |
| A14553 | 29357123 | Compr Physiol | Triglyceride Metabolism in the Liver. | 2017 | Details |
| A14574 | 29345914 | J Agric Food Chem | Comparative Analysis of EPA/DHA-PL Forage and Liposomes in Orotic Acid-Induced Nonalcoholic Fatty Liver Rats and Their Related Mechanisms. | 2018 | Details |
| A14577 | 29343420 | EBioMedicine | AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development. | 2018 | Details |
| A14622 | 29319180 | J Cell Physiol | WISP1 promotes non-alcoholic fatty liver disease and skeletal muscle insulin resistance via TLR4/JNK signaling. | 2018 | Details |
| A14642 | 29311481 | Biol Pharm Bull | A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation. | 2018 | Details |
| A14649 | 29309075 | Food Funct | Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. | 2018 | Details |
| A14669 | 29295591 | Nutrients | Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. | 2017 | Details |
| A14678 | 29290651 | World J Gastroenterol | miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1. | 2017 | Details |
| A14679 | 29290620 | Mol Metab | Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. | 2017 | Details |
| A14696 | 29286302 | Int J Mol Sci | MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish. | 2017 | Details |
| A14718 | 29273476 | J Hepatol | Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. | 2017 | Details |
| A14733 | 29266812 | Mol Nutr Food Res | Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice. | 2018 | Details |
| A14741 | 29263303 | JCI Insight | Intestinal, but not hepatic, ChREBP is required for fructose tolerance. | 2017 | Details |
| A14742 | 29263118 | Physiol Rep | In vitro cellular models of human hepatic fatty acid metabolism: differences between Huh7 and HepG2 cell lines in human and fetal bovine culturing serum. | 2017 | Details |
| A14762 | 29249532 | Clin Nutr | Omega-3 PUFA modulate lipogenesis, ER stress, and mitochondrial dysfunction markers in NASH - Proteomic and lipidomic insight. | 2017 | Details |
| A14764 | 29249184 | Hum Exp Toxicol | Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention. | 2017 | Details |
| A14771 | 29247356 | J Gastroenterol | Current and future pharmacological therapies for NAFLD/NASH. | 2017 | Details |
| A14785 | 29234288 | Front Physiol | Lipocalin-2 in Fructose-Induced Fatty Liver Disease. | 2017 | Details |
| A14790 | 29232555 | Cancer Cell | mTORC2 Promotes Tumorigenesis via Lipid Synthesis. | 2017 | Details |
| A14815 | 29222421 | Sci Rep | The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A14818 | 29221790 | Metabolism | FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes. | 2017 | Details |
| A14875 | 29197188 | FEBS J | Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis. | 2017 | Details |
| A14905 | 29180630 | Sci Rep | ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish. | 2017 | Details |
| A14913 | 29175669 | J Nutr Biochem | Euterpe oleracea Mart. (açaí) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats. | 2017 | Details |
| A14917 | 29175182 | Food Chem Toxicol | Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. | 2017 | Details |
| A14919 | 29174379 | Clin Res Hepatol Gastroenterol | A new pathway to eSCAPe lipotoxicity. | 2017 | Details |
| A14920 | 29174039 | Biomed Pharmacother | Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. | 2017 | Details |
| A14952 | 29158770 | Nutr Metab (Lond) | Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver? | 2017 | Details |
| A14958 | 29156528 | Biomed Pharmacother | Actein ameliorates hepatic steatosis and fibrosis in high fat diet-induced NAFLD by regulation of insulin and leptin resistant. | 2017 | Details |
| A14964 | 29154469 | Pathol Int | Novel non-alcoholic steatohepatitis model with histopathological and insulin-resistant features. | 2017 | Details |
| A14984 | 29141573 | Endocr Metab Immune Disord Drug Targets | Liver Protective Effects of Extra Virgin Olive Oil: Interaction between Its Chemical Composition and the Cell-signaling Pathways Involved in Protection. | 2018 | Details |
| A15000 | 29129237 | Nutrition | Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. | 2017 | Details |
| A15003 | 29128353 | Biochem Biophys Res Commun | Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis. | 2017 | Details |
| A15022 | 29126901 | Biochim Biophys Acta Mol Cell Biol Lipids | Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120). | 2017 | Details |
| A15027 | 29125642 | J Food Sci | Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells. | 2017 | Details |
| A15091 | 29101357 | Sci Rep | MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. | 2017 | Details |
| A15108 | 29090700 | Food Funct | Averrhoa carambola free phenolic extract ameliorates nonalcoholic hepatic steatosis by modulating mircoRNA-34a, mircoRNA-33 and AMPK pathways in leptin receptor-deficient db/db mice. | 2017 | Details |
| A15110 | 29089934 | Front Microbiol | Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver. | 2017 | Details |
| A15145 | 29074727 | Gut | Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. | 2017 | Details |
| A15151 | 29073114 | Proc Natl Acad Sci U S A | Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. | 2017 | Details |
| A15163 | 29066462 | Am J Physiol Endocrinol Metab | Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. | 2017 | Details |
| A15186 | 29057834 | Nutrients | Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper. | 2017 | Details |
| A15189 | 29056532 | Mol Cell Endocrinol | LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. | 2017 | Details |
| A15215 | 29042644 | Sci Rep | HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. | 2017 | Details |
| A15288 | 28986308 | Biochim Biophys Acta Mol Basis Dis | n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD. | 2017 | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | 2017 | Details |
| A15302 | 28973994 | Nutrients | Silibinin Restores NAD⁺ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver. | 2017 | Details |
| A15307 | 28972537 | J Clin Invest | Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. | 2017 | Details |
| A15310 | 28972119 | J Lipid Res | Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet. | 2017 | Details |
| A15344 | 28955124 | J Clin Biochem Nutr | Effects of soy isoflavone on hepatic steatosis in high fat-induced rats. | 2017 | Details |
| A15364 | 28944783 | Analyst | Changes induced by non-alcoholic fatty liver disease in liver sinusoidal endothelial cells and hepatocytes: spectroscopic imaging of single live cells at the subcellular level. | 2017 | Details |
| A15403 | 28928235 | Am J Physiol Endocrinol Metab | Testosterone protects high-fat/low-carbohydrate diet-induced nonalcoholic fatty liver disease in castrated male rats mainly via modulating endoplasmic reticulum stress. | 2017 | Details |
| A15407 | 28926951 | Nutrients | Insights into the Hexose Liver Metabolism-Glucose versus Fructose. | 2017 | Details |
| A15415 | 28923880 | Clin Sci (Lond) | Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets. | 2017 | Details |
| A15439 | 28906444 | Nutrients | Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment. | 2017 | Details |
| A15443 | 28904866 | FEBS Open Bio | IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. | 2017 | Details |
| A15489 | 28878197 | Nutrients | Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A15513 | 28867301 | Cell Metab | Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. | 2017 | Details |
| A15514 | 28867186 | Biochem Biophys Res Commun | Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice. | 2017 | Details |
| A15528 | 28859855 | Gastroenterology | Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. | 2017 | Details |
| A15560 | 28843826 | Eur J Pharmacol | Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis. | 2017 | Details |
| A15587 | 28827398 | Mol Syst Biol | Network analyses identify liver-specific targets for treating liver diseases. | 2017 | Details |
| A15592 | 28824323 | Int J Med Sci | Rhododendron oldhamii leaf extract improves fatty liver syndrome by increasing lipid oxidation and decreasing the lipogenesis pathway in mice. | 2017 | Details |
| A15599 | 28821440 | Cell Signal | Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes. | 2017 | Details |
| A15647 | 28790196 | Sci Signal | TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. | 2017 | Details |
| A15648 | 28789977 | Biochim Biophys Acta Mol Basis Dis | Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. | 2017 | Details |
| A15655 | 28781602 | Nutr Metab (Lond) | eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. | 2017 | Details |
| A15656 | 28777914 | Can J Physiol Pharmacol | Resveratrol improves high-fat diet induced fatty liver and insulin resistance by concomitantly inhibiting proteolytic cleavage of sterol regulatory element-binding proteins, free fatty acid oxidation, and intestinal triglyceride absorption. | 2017 | Details |
| A15679 | 28768172 | Cell Metab | Sweet Sixteenth for ChREBP: Established Roles and Future Goals. | 2017 | Details |
| A15690 | 28759573 | PLoS One | Alternation of plasma fatty acids composition and desaturase activities in children with liver steatosis. | 2017 | Details |
| A15696 | 28754826 | J Lipid Res | Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver. | 2017 | Details |
| A15732 | 28739572 | Mol Pharmacol | Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. | 2017 | Details |
| A15734 | 28737815 | Food Funct | Isofraxidin, a coumarin component improves high-fat diet induced hepatic lipid homeostasis disorder and macrophage inflammation in mice. | 2017 | Details |
| A15781 | 28711683 | Biochimie | Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): Hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice. | 2017 | Details |
| A15819 | 28694655 | World J Gastroenterol | Antioxidant dietary approach in treatment of fatty liver: New insights and updates. | 2017 | Details |
| A15859 | 28678199 | Int J Mol Sci | The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver. | 2017 | Details |
| A15860 | 28677866 | J Appl Toxicol | Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. | 2017 | Details |
| A15862 | 28677333 | Aliment Pharmacol Ther | Review article: new treatments in non-alcoholic fatty liver disease. | 2017 | Details |
| A15888 | 28670394 | Am J Transl Res | PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E-/- mice and Changliver cell[S]. | 2017 | Details |
| A15892 | 28667519 | Sci China Life Sci | Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. | 2017 | Details |
| A15893 | 28667176 | J Mol Endocrinol | miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. | 2017 | Details |
| A15920 | 28652650 | World J Gastroenterol | Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease. | 2017 | Details |
| A15925 | 28648927 | J Ethnopharmacol | Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. | 2017 | Details |
| A15941 | 28642009 | Toxicol Lett | Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress. | 2017 | Details |
| A15954 | 28638220 | World J Gastroenterol | Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats. | 2017 | Details |