Repositioning Candidates

Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.

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     Caspase-3
18 records.
Candidate ID Source ID Source Type Compound Type Candidate Name Inclusion Criteria
R0104 DB00282 approved small molecule Pamidronic acid Therapeutic strategy associated Details
R0249 DB00710 approved; investigational small molecule Ibandronate Therapeutic strategy associated Details
R0372 DB01017 approved; investigational small molecule Minocycline Target associated Details
R0575 DB03124 experimental small molecule 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Target associated Details
R0960 DB06255 experimental small molecule Incadronic acid Therapeutic strategy associated Details
R0963 DB06263 investigational small molecule Amrubicin Therapeutic strategy associated Details
R1033 DB06506 investigational small molecule Repinotan Indication associated Details
R1109 DB06862 experimental small molecule 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID Target associated Details
R1125 DB07696 experimental small molecule methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate Target associated Details
R1137 DB08213 experimental small molecule 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE Target associated Details
R1139 DB08229 experimental small molecule [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid Target associated Details
R1141 DB08251 experimental small molecule 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID Target associated Details
R1145 DB08497 experimental small molecule (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Target associated Details
R1146 DB08498 experimental small molecule (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Target associated Details
R1147 DB08499 experimental small molecule N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Target associated Details
R1340 DB11125 approved small molecule Benzethonium Therapeutic strategy associated Details
R1458 DB12651 investigational small molecule Bardoxolone Therapeutic strategy associated Details
R1494 DB13751 approved; experimental small molecule Glycyrrhizic acid Therapeutic strategy associated Details