Bioactive Compound Details
| Compound ID: | B140616 |
| Source ID: | CHEMBL468 |
| Source Type: | Small molecule |
| Compound Name: | THALIDOMIDE |
| Synonyms: | .ALPHA.-PHTHALIMIDOGLUTARIMIDE|CELGENE|CONTERGAN|DISTAVAL|K-17|MYRIN|N-PHTHALYLGLUTAMIC ACID IMIDE|NEUROSEDYN|NSC-527179|NSC-66847|PANTOSEDIV|PHARMION|SOFTENON|TALIDEX|THALED|THALIDOMIDE|THALIDOMIDE |Thalomid |
| Molecular Formula: | C13H10N2O4 |
| SMILES: | O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |
| T08 | Tumor necrosis factor | TNF | inhibitor | Cytokine | P01375 | TNFA_HUMAN | Details |