Bioactive Compound Details
| Compound ID: | B145883 |
| Source ID: | CHEMBL998 |
| Source Type: | Small molecule |
| Compound Name: | LORATADINE |
| Synonyms: | Alavert|BAY76-2211|CHILDREN'S CLARITIN|CLARITIN HIVES RELIEF|CLARITIN HIVES RELIEF REDITAB|CLARITIN REDITABS|CLARITYN|CLARITYN RAPIDE|CLARITYNE|Claritin|Claritin-D|HAY-RITE|LORATADINE|LORATADINE REDIDOSE|NSC-758628|ROLETRA|SCH 29851|SCH-29851 |
| Molecular Formula: | C22H23ClN2O2 |
| SMILES: | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T06 | Glucagon-like peptide 1 receptor | GLP1R | agonist | GPCR | P43220 | GLP1R_HUMAN | Details |