Bioactive Compound Details
| Compound ID: | B001581 |
| Source ID: | CHEMBL119385 |
| Source Type: | Small molecule |
| Compound Name: | NEFLAMAPIMOD |
| Synonyms: | 745|NEFLAMAPIMOD|VD-31|VD-31,745|VD-31745|VRT-031745|VX-745 |
| Molecular Formula: | C19H9Cl2F2N3OS |
| SMILES: | O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl |
| Molecular Species: | None |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T14 | Mitogen-activated protein kinase kinase kinase 5 | MAP3K5 | inhibitor | Enzyme | Q99683 | M3K5_HUMAN | Details |
| T42 | Serine/threonine-protein kinase 17B | STK17B | inhibitor | Kinase | O94768 | ST17B_HUMAN | Details |