Bioactive Compound Details
| Compound ID: | B016100 |
| Source ID: | CHEMBL135 |
| Source Type: | Small molecule |
| Compound Name: | ESTRADIOL |
| Synonyms: | 17-.BETA.-OESTRADIOL|17-BETA-OESTRADIOL|17.BETA.-ESTRADIOL|17BETA-ESTRADIOL|ADGYN ESTRO|AGOFOLLIN|Alfatradiol|Alora|Aquagen|BEDOL|Climara|Climara Pro|DERMESTRIL 100|DERMESTRIL 25|DERMESTRIL 50|DERMESTRIL SEPTEM 25|DERMESTRIL SEPTEM 50|DERMESTRIL SEPTEM 75|DESTRADIOL|DIHYDROTHEELIN|DIHYDROXYESTRIN|DIVIGEL|Depo-Estradiol|E-Cypionate|ELESTRIN|ELLESTE SOLO|ELLESTE SOLO MX 40|ELLESTE SOLO MX 80|ESCLIM|ESTRADERM MX 100|ESTRADERM MX 25|ESTRADERM MX 50|ESTRADERM MX 75|ESTRADERM TTS 100|ESTRADERM TTS 25|ESTRADERM TTS 50|ESTRADIOL|ESTRADIOL 17-BETA|ESTRADIOL ANHYDROUS|ESTRADIOL HEMIHYDRATE|ESTRADIOL VALERATE METABOLITE E2|ESTRASORB|EVAMIST|EVOREL 100|EVOREL 25|EVOREL 50|EVOREL 75|Elestrim|Estrace|Estraderm|Estradiol|Estradiol hemihydrate|Estrasorb|Estring|Estrogel|FEMATRIX 40|FEMATRIX 80|FEMSEVEN 100|FEMSEVEN 50|FEMSEVEN 75|Fempatch|GYNERGON|GYNODIOL|GYNOESTRYL|Gvnodiol|Gynogen|IMVEXXY|Innofem|MENOREST 37.5|MENOREST 50|MENOREST 75|MENORING 50|MINIVELLE|Menostar|NSC-20293|NSC-9895|OESTRADIOL|Oestradiol|PROGYNOVA TS|SANDRENA|VIVELLE-DOT|Vagifem|Vagifem 18|Vagifem 8|Vivelle|WC-3011|WC3011|ZUMENON |
| Molecular Formula: | C18H24O2 |
| SMILES: | C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |